1984
DOI: 10.1016/0378-5173(84)90113-3
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Drug release from non-aqueous suspensions. II. The release of methylxanthines from paraffin suspensions

Abstract: SummaryThe release of 3 methylxanthines, i.e. caffeine, theobromine and theophylline, from suspensions in liquid paraffin to an aqueous phase was determined in an in vitro apparatus. The release rates were determined as a function of the pii of the aqueous phase. It was proved that the release process was natural convection-regulated. The release rate per unit area was correlated to the solubility of the drug to the power 1 .l 1. In case of the release of theophylfine anhydrate from the suspensions a cake of t… Show more

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Cited by 6 publications
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