Drug release from polyureaurethane coating modified by plasma immersion ion implantation

Abstract

A crosslinked polyurethanurea (PUU) coating was synthesised from a solution on metal vascular stents. In the model system the glucocorticoid prednisolone was inserted into the film by the equilibrium swelling method; after this plasma immersion ion implantation (PIII) was applied to modify the coating for improved release kinetics. This treatment causes the formation of oxygen-containing and unsaturated carbon-carbon groups in the PUU and a destruction of the drug in the surface layer. As a consequence, the release rate of prednisolone to water becomes more stable with time than it is at the untreated coating. In this drug release system PIII treatment prevents an initial toxically high release of the drug. By this it allows the incorporation of a higher amount of the drug and an extended action.

Synthesis, Characterization, and Paclitaxel Release from a Biodegradable, Elastomeric, Poly(ester urethane)urea Bearing Phosphorylcholine Groups for Reduced Thrombogenicity

“…Nonthrombogenicity and the prevention of intimal hyperplasia are two critical features desired in polymer-coated, drug-eluting, vascular stents. Elastomeric polyurethanes have served as coating materials for vascular expandable stents due to their high distensibility, processability, and biocompatibility. − Nonthrombogenic moieties, such as PC, , sulfobetain, − sulfate, , and poly(ethylene glycol), have been physically and chemically combined with polyurethanes broadly intended for cardiovascular application in an effort to improve their blood compatibility. Among these, PC has been most frequently studied.…”

Coronary stents: A materials perspective

“…It was also reported that PU coatings can improve endothelialization [171]. PU has also been investigated in drug delivery systems [172][173][174]. Lambert et al [172] successfully studied the drug release kinetics and distribution of the model drug Forskolin delivered from the PU coated metallic stents.…”

Surface attachment of horseradish peroxidase to nylon modified by plasma‐immersion ion implantation

“…Ion‐beam implantation and PIII have been used for the modification of polyethylene, 13–21 polystyrene, 22–28 polytetrafluoroethylene, 29–34 poly(ethylene terephthalate), 35–38 poly(methyl methacrylate), 39–42 polyurethane, 43–47 and other polymers. Leading to increases in the hardness, electrical conductivity, and wettability, structural changes typical of ion‐irradiated polymers, such as carbonization, depolymerization, and oxidation, have been observed.…”