Drug release from silicone elastomer through controlled polymer cracking: an extension to macromolecular drugs

Comparative study of the release kinetics of osmotically active solutes from hydrophobic elastomeric matrices combined with the characterization of the depleted matrices

“…Moreover, another well‐known method for promoting the release of hydrophilic drugs and proteins or accelerating the release of lipophilic ones is the use of osmotically active excipients, which, by causing an osmotic influx of water inside the matrices, alleviate the restrictions that the polymer poses on the release of the drugs. The use of osmotically active excipients has been applied both to the release of proteins9 and drugs10–13 from SR elastomers and the release of proteins from other elastomeric systems 14–17…”

Regulation of proxyphylline's release from silicone rubber matrices by the use of osmotically active excipients and a multi-layer system

“…In this case, permeation of the solute through the polymer matrix can be markedly facilitated, and its release rate may be regulated, by the presence of osmotically active excipients, a methodology which has been applied to systems based on silicone elastomers. In particular, Carelli et al (1989) have demonstrated the release of bovine serum albumin (BSA) in the presence of NaCl from silicone rubber (SR) matrices, Dash and Suryanarayanan (1992) have studied the enhancement that glycerol offers on the release of tobramycin, Kajihara et al (2000) have studied the release of interferon in the presence of human serum albumin while Woolfson et al (2006) have demonstrated the regulation of dapivirine through the use of lactose. Moreover, other relevant examples involve the release of interferon-gamma (Gu et al, 2005) and interleukin-2 or vascular endothelial growth factor (Gu et al, 2007) from degradable elastomers, synthesized from photo-cross-linked prepolymers of ,,,-triacrylate [star-poly(-caprolactone-co-d,l-lactide)], by the use of an osmotic pressure delivery mechanism, produced by embedded excipients such as trehalose.…”

Thermo-Sensitive Release Behavior of 5-Fluorouracil from Chitosan-Gel Microspheres Coated with Lipid Multilayers

“…In order to provide a delivery device displaying a zero order drug release rate, many efforts have been made to create controlled release systems using polymers such as polylactide [1][2][3], silicone-rubber [4], poly(ortho ester) [5], albumin [6,7] and fibrinogen [8]. Recently, new types of drug delivery systems which can control drug release in response to a physical, biological or chemical signal such as pH [9,10], temperature [11][12][13], microwave irradiation [14], magnetism [15], and blood sugar [16,17] have been investigated.…”