Drug release properties of polyethylene-glycol-treated ciprofloxacin-Indion 234 complexes

Abstract

The polyethylene glycol (PEG) treatment of ciprofloxacinIndion 234 complex was aimed to retard rapid ion exchange drug release at gastric pH. Ciprofloxacin loading on Indion 234 was performed in a batch process, and the amount of K + in Indion 234 displaced by drug with time was studied as equilibrium constant K DM . Drug-resin complex (DRC) was treated with aqueous PEG solution (0.5%-2% wt/vol) of different molecular weights (MWs) for 2 to 30 minutes. The PEG-treated ciprofloxacin-Indion 234 complex was evaluated for particle size, water absorption time, and drug release at gastric pH. During drug loading on Indion 234, the equilibrium constant (K DM ) increased rapidly up to 20 minutes with efficient drug loading. Increased time of immersion of the drug resinate in PEG solutions significantly retained higher size particles upon dehydration. The larger DRC particles showed longer water absorption times owing to compromised hydrating power. The untreated DRC showed insignificant drug release in deionized water; while at gastric pH, ciprofloxacin release was complete in 90 minutes. A trend of increased residual particle size, proportionate increase in water absorption time, and hence the retardation of release with time of immersion was evident in PEG-treated DRC. The time of immersion of DRC in PEG solution had predominant release retardant effect, while the effect of molecular weight of PEG was insignificant. Thus, PEG treatment of DRC successfully retards ciprofloxacin ion exchange release in acidic pH.

Development and in vitro characterization of a multiparticulate delivery system for acyclovir-resinate complex

“…Initially, the binding sites in the cholestyramine resin are well-occupied by counter-ions (Cl  ). Once exposed to a drug solution, the counter-ions on the surface are displaced by drug ions and carried away by the well-stirred bulk liquid (Pisal et al 2004). ACV-cholestyramine complexation was increased with an increase in concentration of drug solution.…”

Incorporation of drug-resin complex to improve microsphere performance

“…The suspension was filtered; separated resin (acid activated) was rewashed with deionised water several times till neutral pH and kept in desiccator to dry and for further use. [10] Optimization of drug resin complexation process The batch process was adopted for complexation of ODH with Indion 244. Both the ODH, activated and dried Indion 244, were taken in various proportions viz: 1:1, 1:1.2, 1:1.4, 1:1.6, 1:1.8, 1:2, 1:2.2, 1:2.4, 1:2.8, 1:3.2, respectively, in 10 mL of deionised water separately.…”

“…Pisal et al, have demonstrated the similar findings for complexation efficiency of ciprofloxacin hydrochloride and Indion 234. [10] This poor complexation efficiency might have been seen due to higher degree of cross-linking of resin having tighter pore structure and smaller pore size preventing access of the drug molecule to the ionic site in the resin particle. [23] Evaluation of microspheres Process yield Yield of microspheres was found to be dependent on both amount of HPMC and EC, and was in the range of 48.35 ± 3.03 % w/w to 84.87 ± 3.95% w/w [ Table 2].…”

Comparative study of ion-exchange resin Indion 204 and Indion 214 for the taste masking of metoclopramide hydrochloride and formulation of rapid-disintegrating tablets

“…A numerical scale was used with the following values: 0 = tasteless, 1= acceptable bitterness, 2= slight bitterness, 3= moderately bitterness and 4= strong bitterness. [8,9] Determination of drug content Resinate equivalent to 10 mg of drug was stirred with 100 ml of 0.1N HCl for 60 min, till the entire drug leached out, then the solution was filtered. Dilutions were made with 0.1N HCl and the drug content was noted spectrophotometrically at 308 nm.…”