Drug Releasing Polymer Thin Films: New Era of Surface-Mediated Drug Delivery

Zelikin, Alexander N.

doi:10.1021/nn100634r

Cited by 275 publications

(234 citation statements)

References 115 publications

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“…To address this, electronically controlled drug release has been demonstrated from PPy films coated on implants and prostheses. Functionalized prostheses fabricated with an antibiotic coating prevented infection at the site of implantation and improved integration of the prosthesis with surrounding tissue [113]. Ti is the most widely used material for bone and joint prostheses in hospitals with a high probability of an infection due to the invasive surgery needed for implantation.…”

Section: Infectionmentioning

confidence: 99%

Organic Bioelectronic Tools for Biomedical Applications

2015

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Abstract:Organic bioelectronics forms the basis of conductive polymer tools with great potential for application in biomedical science and medicine. It is a rapidly growing field of both academic and industrial interest since conductive polymers bridge the gap between electronics and biology by being electronically and ionically conductive. This feature can be employed in numerous ways by choosing the right polyelectrolyte system and tuning its properties towards the intended application. This review highlights how active organic bioelectronic surfaces can be used to control cell attachment and release as well as to trigger cell signaling by means of electrical, chemical or mechanical actuation. Furthermore, we report on the unique properties of conductive polymers that make them outstanding materials for labeled or label-free biosensors. Techniques for electronically controlled ion transport in organic bioelectronic devices are introduced, and examples are provided to illustrate their use in self-regulated medical devices. Organic bioelectronics have great potential to become a primary platform in future bioelectronics. We therefore introduce current applications that will aid in the development of advanced in vitro systems for biomedical science and of automated systems for applications in neuroscience, cell biology and infection biology. Considering this broad spectrum of applications, organic bioelectronics could lead to timely detection of disease, and facilitate the use of remote and personalized medicine. As such, organic bioelectronics might contribute to efficient healthcare and reduced hospitalization times for patients. OPEN ACCESSElectronics 2015, 4 880

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Section: Infectionmentioning

confidence: 99%

Organic Bioelectronic Tools for Biomedical Applications

2015

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“…[15][16][17][18][19][20] The performance of these multilayer devices are strongly dependent on the diffusivity of drug molecules (or other relevant bioactive species) within these polymers whose thicknesses can range from nanometres to microns. [21][22][23] There are some recent studies which have used the FRAP phenomenon to study diffusion of proteins in PEMs as well as inter-diffusion of the components of the PEM system within the multilayer stack. [24,25] These studies assumed an analytical model of fluorescence recovery which is (a) more appropriate for a closed system such as a cell and (b) assumed only diffusion to be the mechanism of recovery while ignoring other effects such as adsorption and desorption of the molecules to the PEM matrix.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Recovery After Photobleaching in Ultrathin Polymer Films

Prakash

Pahal

Varma

2017

Preprint

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Fluorescence recovery after photobleaching (FRAP) is a widely used technique to study transport of molecules in biological systems. Recently, FRAP has been used to study molecular transport in polyelectrolyte multilayers (PEMs). Through numerical simulations verified by experiments, we show that the FRAP behaviour of PEM films in an aqueous medium differs significantly from that in previously explored systems such as single cells. This is because fluorescence recovery can take place through the aqueous medium surrounding the PEM film. Our simulations show the critical role of the time scale of the different processes namely, diffusion through PEM, diffusion through surrounding medium and the unbinding rate of fluorophore labelled species in the interpretation of FRAP data. An important conclusion from our numerical and experimental study is that, for ultrathin PEM films ~ 100 nm thicknesses, recovery is dominated through solution medium and hence, classical FRAP analysis is not sufficient to probe diffusion in PEM. Our numerical study reveals several aspect of FRAP phenomena in thin polymer films which are critical for the proper interpretation of experimental data.

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“…There are many different examples of material used to create thin films including those of both dielectric 2 and metallic character. 3 Well-known examples of their use include anti-reflective 4 and high-reflection coatings 5 , with more contemporary applications including drug delivery, 6 electronics, 7 and solar energy systems. 8 The simplest effect of thin films in conjunction with light can be understood through what is known as thin film interference, where the throughput is modified through transmission and reflection.…”

Section: Introductionmentioning

confidence: 99%

Quantum theory for the nanoscale propagation of light through stacked thin film layers

2016

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Stacked multi-layer films have a range of well-known applications as optical elements. The various types of theory commonly used to describe optical propagation through such structures rarely take account of the quantum nature of light, though phenomena such as Anderson localization can be proven to occur under suitable conditions. In recent and ongoing work based on quantum electrodynamics, it has been shown possible to rigorously reformulate, in photonic terms, the fundamental mechanisms that are involved in reflection and optical transmission through stacked nanolayers. Accounting for sum-over-pathway features in the quantum mechanical description, this theory treats the sequential interactions of photons with material boundaries in terms of individual scattering events. The study entertains an arbitrary number of reflections in systems comprising two or three internally reflective surfaces. Analytical results are secured, without recourse to FTDT (finite-difference time-domain) software or any other finite-element approximations. Quantum interference effects can be readily identified. The new results, which cast the optical characteristics of such structures in terms of simple, constituent-determined properties, are illustrated by model calculations.

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Drug Releasing Polymer Thin Films: New Era of Surface-Mediated Drug Delivery

Cited by 275 publications

References 115 publications

Organic Bioelectronic Tools for Biomedical Applications

Organic Bioelectronic Tools for Biomedical Applications

Fluorescence Recovery After Photobleaching in Ultrathin Polymer Films

Quantum theory for the nanoscale propagation of light through stacked thin film layers

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