Drug repurposing for bacterial infections

Ilyas, Mahnoor; Latif, Muhammad Saad; Gul, Alvina; Babar, Mustafeez Mujtaba; Rajadas, Jayakumar

doi:10.1016/bs.pmbts.2024.03.031

Progress in Molecular Biology and Translational Science

2024

DOI: 10.1016/bs.pmbts.2024.03.031

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Drug repurposing for bacterial infections

Mahnoor Ilyas,

Muhammad Saad Latif,

Alvina Gul

et al.

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2024

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Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection

Guin,

Montoya,

Wang

et al. 2024

Antimicrob Agents Chemother

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Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives of the malarial drug mefloquine have broad-spectrum antifungal activity including difficult-to-treat molds and endemic fungi. Pharmacokinetic and efficacy studies of NSC-4377 indicate that it penetrates the central nervous system and is active against Candida auris in vivo . These data strongly support the further development of mefloquine analogs as a potentially new class of antifungal molecules.

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Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection

Guin,

Montoya,

Wang

et al. 2024

Antimicrob Agents Chemother

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show abstract

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Drug repurposing for bacterial infections

Cited by 1 publication

References 72 publications

Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection

Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection

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