Drug repurposing opportunities for chronic kidney disease

Chen, Xiong; Shen, Runnan; Zhu, Dongxi; Luo, Shulu; You, Guochang; Li, Ruijie; Hong, Xiaosi; Li, Ruijun; Wu, Jihao; Huang, Yinong; Lin, Tianxin

doi:10.1016/j.isci.2024.109953

iScience

2024

DOI: 10.1016/j.isci.2024.109953

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Drug repurposing opportunities for chronic kidney disease

Xiong Chen,

Runnan Shen,

Dongxi Zhu

et al.

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Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan

Chen,

Chiang,

Chang

et al. 2024

Nat Commun

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Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs ( n = 244,952) on estimated glomerular filtration rate and a replication dataset ( n = 27,058) from Taiwan and Japan. This study identified 111 lead SNPs in 97 genomic risk loci. Functional enrichment analyses revealed that variants associated with F12 gene and a missense mutation in ABCG2 may contribute to chronic kidney disease (CKD) through influencing inflammation, coagulation, and urate metabolism pathways. In independent cohorts from Taiwan ( n = 25,345) and the United Kingdom ( n = 260,245), polygenic risk scores (PRSs) for CKD significantly stratified the risk of CKD ( p < 0.0001). Further research is required to evaluate the clinical effectiveness of PRS CKD in the early prevention of kidney disease.

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Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan

Chen,

Chiang,

Chang

et al. 2024

Nat Commun

View full text Add to dashboard Cite

show abstract

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Drug repurposing opportunities for chronic kidney disease

Cited by 1 publication

References 53 publications

Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan

Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan

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