2021
DOI: 10.34172/joddd.2021.036
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Drug resistance against 5-fluorouracil and cisplatin in the treatment of head and neck squamous cell carcinoma: A systematic review

Abstract: Head and neck cancers are highly prevalent worldwide. Most of these lesions are diagnosed in the advanced stages of the disease. Thus, they do not often have a good long-term prognosis. Like other cancer types, head and neck cancers are managed by surgery, radiotherapy, and chemotherapy. Despite significant advances in the treatment of oral squamous cell carcinoma (OSCC), physicians encounter several challenges in the course of treatment. Various mechanisms mediate the clinical responses of a certain cancer to… Show more

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Cited by 26 publications
(16 citation statements)
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“…Many studies have been conducted to date to understand the mechanisms leading to chemoresistance to Cisplatin in cancers, but it is not yet fully understood [26]. Based on a meta-analysis using ten studies (sample size = 1317), Atashi et al reported 33% cisplatinresistance [27]. Since cisplatin is the first-line systemic treatment for HNC, it then becomes important to overcome cisplatinresistance to improve prognosis [28].…”
Section: Head and Neck Cancersmentioning
confidence: 99%
“…Many studies have been conducted to date to understand the mechanisms leading to chemoresistance to Cisplatin in cancers, but it is not yet fully understood [26]. Based on a meta-analysis using ten studies (sample size = 1317), Atashi et al reported 33% cisplatinresistance [27]. Since cisplatin is the first-line systemic treatment for HNC, it then becomes important to overcome cisplatinresistance to improve prognosis [28].…”
Section: Head and Neck Cancersmentioning
confidence: 99%
“…Patients with recurrent OSCC have been reported to have failed treatment due to resistance to chemotherapy drugs, resulting in low survival rates ( Wang B. et al, 2013 ; Wang et al, 2016 ). 5-Fluorouracil (5-FU) is one of the most used chemotherapy drugs for treating OSCC, although the anti-tumour efficacy is affected by side effects and tumour resistance ( Longley et al, 2003 ; Atashi et al, 2021 ). Meng et al ( Yang et al, 2021 ) found that bitter melon-derived extracellular vesicles (BMEVs) are an intrinsically biologically active form of cancer treatment and potential nano-delivery carriers.…”
Section: Application Of Plant-derived Extracellular Vesicles As the N...mentioning
confidence: 99%
“…5-Fluorouracil (5FU), as a rst-line chemotherapeutic drug, can inhibit the growth of tumor cells by inhibiting thymidylate synthase and integrating its metabolites into RNA and DNA, thus causing DNA damage [9]. Despite the remarkable e cacy of 5FU in tumor treatment, there is growing clinical evidence that the development of drug resistance severely limits its clinical potential, ultimately leading to tumor recurrence, metastasis, and subsequent treatment failure [10,11]. A groundbreaking meta-analysis reported a modest overall survival advantage of 4% for chemotherapy at both the 2-and 5-year marks in patients with OSCC [12], highlighting that drug resistance limits improvement in overall survival [10,13].…”
Section: Introductionmentioning
confidence: 99%