Drug Resistance in Breast Cancer

Paul, Devchand; Cowan, Kenneth H.

doi:10.1007/978-1-59259-456-6_23

Cited by 6 publications

(2 citation statements)

References 200 publications

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“…Increased drug efflux is a common mechanism of resistance in cancer cells, which is frequently seen following exposure of tumor cells to one of the "naturally occurring" anticancer drugs like doxorubicin, vincristine, etoposide, paclitaxel etc. (1). The increased drug efflux is mediated by membrane transporter proteins.…”

Section: Introductionmentioning

confidence: 99%

“…These membrane proteins are physiological pumps that remove unwanted chemicals. MDR1 is the most commonly used membrane pump that is involved in conferring resistance to cancer chemotherapy (1). A second family of such pumps has gained attention due to their ability to modulate drug resistance, the multidrug resistance-associated proteins (MRPs).…”

Section: Introductionmentioning

confidence: 99%

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Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

Abaan

Mutlu

Baran

et al. 2009

Cancer Investigation

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

Abaan

Mutlu

Baran

et al. 2009

Cancer Investigation

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Reversal of Multidrug Resistance by Synthetic and Natural Compounds in Drug-Resistant MCF-7 Cell Lines

et al. 2008

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Background: Ineffectiveness of anticancer drugs is frequently observed in cancer chemotherapy. The resistance of tumor cells to various cytotoxic drugs is defined as multidrug resistance (MDR). The purpose of this study is to investigate the potential reversal effect of some synthetic and natural chemicals on drug-resistant MCF-7 cell lines. The effects of potential MDR modulators combined with some anticancer drugs were also studied. Methods: Flow cytometry, MTT cytotoxicity assays and checkerboard combination assays were performed to study the reversal of drug resistance and to investigate the antiproliferative effects of the combination of anticancer drugs and the potential modulators. The results indicated that verapamil, capsanthin, zeaxanthin and promethazine inhibited P-gp effectively, but chrysin was not effective at reversing the resistance in MCF-7 sublines. Four selective anticancer drugs (paclitaxel, docetaxel, doxorubicin and vincristine) and 4 effective MDR modulators (verapamil, capsanthin, zeaxanthin and promethazine) were applied to the sublines in combination. Results and Conclusion: Fractional inhibitory indices show that verapamil and zeaxanthin seem to be the most effective MDR reversal agents that may be used together with paclitaxel, docetaxel, vincristine and doxorubicin in drug-resistant mammary carcinoma sublines. In conclusion, this report represents the importance to find out active and efficient drug resistance modulators for improving the efficacy of chemotherapy.

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The Involvement of Heat Shock Proteins and Related Molecules in the Resistance to Therapies in Breast and Gynecologic Cancer

Carrión¹,

Fanelli²,

Castro³

et al. 2016

CCTR

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Drug Resistance in Breast Cancer

Cited by 6 publications

References 200 publications

Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

Reversal of Multidrug Resistance by Synthetic and Natural Compounds in Drug-Resistant MCF-7 Cell Lines

The Involvement of Heat Shock Proteins and Related Molecules in the Resistance to Therapies in Breast and Gynecologic Cancer

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