Drug Resistant Enterococci in a South Indian Hospital

Bhat, Kamalakshi G.; Paul, Chitra; Ananthakrishna, NC

doi:10.1177/004947559802800220

Cited by 17 publications

(16 citation statements)

References 3 publications

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“…This has been reported in earlier studies as well. 7,15 In our study, the highest resistance was seen against erythromycin, which is in agreement with other studies carried out in India. 16,17 In this study, occurrence of HLGR was 86.6% amongst the total Enterococcal isolates, being higher in E. faecium isolates as compared to E. faecalis although the difference was not statistically significant (P 0.294).…”

Section: Discussionsupporting

confidence: 92%

Speciation and Drug Susceptibility Testing Including Minimum Inhibitory Concentration for Vancomycin in Clinical Isolates of Enterococci

Jagdev¹,

Gupte²,

Aggarwal³

et al. 2016

jemds

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Section: Discussionsupporting

confidence: 92%

Speciation and Drug Susceptibility Testing Including Minimum Inhibitory Concentration for Vancomycin in Clinical Isolates of Enterococci

Jagdev¹,

Gupte²,

Aggarwal³

et al. 2016

jemds

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“…This disparity in resistance rate might be because of differences in strain properties, sample size, sex, age or even methods of studies. Overall resistance to antibiotics was higher among E. faecium rather than E. faecalis, which is in agreement with other reports (Bhat et al, 1998;Fernandes & Dhanashree, 2013;Mendiratta et al, 2008).…”

Section: Discussionsupporting

confidence: 92%

“…According to the results of the present study the prevalence of E. faecalis among infectious clinical samples was about 2 fold higher than E. faecium, similar results have been reported from other studies in Iran (Jabalameli et al, 2009;Sharifi et al, 2013), Malaysia (Sharifi et al, 2013), central and south India (Bhat, Paul, & Ananthakrishna, 1998;Fernandes & Dhanashree, 2013;Mendiratta et al, 2008); while in some other studies the prevalence of E. faecium has been reported higher than E. faecalis (Kapoor, Randhawa, & Deb, 2005). Fernandes and Dhanashree (2013) suggested that possessing the hemolysin and gelatinase might be the reason of higher prevalence of E. faecalis in infectious samples (Fernandes & Dhanashree, 2013).…”

Section: Discussionsupporting

confidence: 92%

The Correlation between Resistance to Antimicrobial Agents and Harboring Virulence Factors among Enterococcus Strains Isolated from Clinical Samples

Arbabi¹,

Boustanshenas²,

Rahbar³

et al. 2016

JMBR

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Objectives: In Iran as well as throughout the world Enterococci have been rated as the important cause of urinary tract and nosocomial infections. The aim of this study was to evaluate the relationship between high antimicrobial resistance activity and harboring the virulence factors among clinical Enterococcus isolates. Materials and Methods:Clinical strains were isolated from hospitalized patients. Prevalence of different virulence genes was evaluated by PCR method and the relation between resistance to antibiotics and harboring virulence genes was evaluated by statistical analysis. Results:The results showed that E. faecalis (60%) is more prevalent than E. faecium (26%) and harboring more virulence factors. The highest resistance was related to gentamicin in both E. faecalis and E. faecium isolates with the rate of 88.7% and 93.5% respectively. Harboring esp, ace and cylA are significantly related to resistance to different antibiotics. Conclusion:The antimicrobial resistance and virulence pattern of Enterococcus must be constantly monitored in order to choose the best antimicrobial treat and prevent nosocomial infections. Keywords: antimicrobial resistance, virulence factors, enterococcus, IranHighlights: The E. faecalis is more prevalent than E. faecium among hospitalized patients. The E. faecalis harboring more virulence factors rather than E. faecium. Gentamicin was detected as the most resistance antibiotics among all isolates. The significant correlation between harboring esp, ace and cylA and resistance to antibiotics has been detected.

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“…The distribution of ratio of E. faecalis to E. faecium is similar to the study conducted by other authors. 4,[11][12][13][14] According to study conducted by Marothi et al, most frequent infections caused by enterococci are urinary tract infections followed by infections of intra-abdominal and pelvic abscesses or post-surgery wound infections whereas in our study most of the Enterococcal isolates were isolated from urine (44%), Pus (51%) and others specimen (5%, which includes blood 80% and drain tube 20%). 15 These results were similar to the results conducted by Sanal et al, were the maximum number of isolates was obtained from urine.…”

Section: Discussionmentioning

confidence: 71%

A study on virulence factors and antimicrobial resistance pattern among enterococci isolated from various clinical specimens from a tertiary care hospital

et al. 2017

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Background: Enterococci, adult faeces commensal are important nosocomial pathogens. E. faecalis is the most common cause of infection, followed by E. faecium. In the past two decades, they have developed resistance to many commonly used antimicrobial agents. Understanding virulence factors and monitoring antimicrobial resistance among Enterococci is essential for controlling the spread of bacterial resistance and important for epidemiological surveillance within the hospital environment. The aim of the study is to evaluate antibiotic resistance and virulence factors exhibited by Enterococcus sp.Methods: One hundred consecutive isolates of Enterococci isolated from different clinical samples of patients attending AVMC and H, a tertiary care center at Pondicherry in a period of 20 months were included in the study. Enterococcus sp were identified as per standard conventional bacteriologic methods and detected for the production of virulence factors such as Hemolysin production, Gelatinase production. Antimicrobial susceptibility testing was carried out by disc diffusion method and MIC of vancomycin and teicoplanin was determined by E-test strips.Results: Among 100 Enterococcal isolates included in the study, 81% were E. faecalis and 19% were E. faecium which were isolated from urine (44%), Pus (51%) and others specimen (5%, which includes blood 80% and drain tube 20%). In this study, overall 15% of E. faecalis and 1% of E. faecium showed hemolysin production and Gelatinase was produced by 6% of E. faecalis and 4% of E. faecium. Majority of E. faecalis and E. faecium strains isolated in our study, had increased sensitivity were to be exhibited for Linezolid, Vancomycin followed by high level gentamycin and high degree of resistance to penicillin, ciprofloxacin and cotrimoxazole. Analyzing the results of MIC of vancomycin and teicoplanin, 5 isolates were classified phenotypically as VanB phenotype that possess only moderate to high levels of vancomycin resistance and one isolate obtained from drain tube which showed MIC of vancomycin as 120µg/ml and teicoplanin 16µg/ml was grouped into VanA.Conclusions: Though the prevalence of vancomycin resistant Enterococcci (VRE) is very low in our study, yet regular monitoring of vancomycin resistance is very crucial for early detection, treatment, application of preventive and control measures and most importantly to check the spread of virulent multidrug resistant Enterococcus species.

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Drug Resistant Enterococci in a South Indian Hospital

Cited by 17 publications

References 3 publications

Speciation and Drug Susceptibility Testing Including Minimum Inhibitory Concentration for Vancomycin in Clinical Isolates of Enterococci

Speciation and Drug Susceptibility Testing Including Minimum Inhibitory Concentration for Vancomycin in Clinical Isolates of Enterococci

The Correlation between Resistance to Antimicrobial Agents and Harboring Virulence Factors among Enterococcus Strains Isolated from Clinical Samples

A study on virulence factors and antimicrobial resistance pattern among enterococci isolated from various clinical specimens from a tertiary care hospital

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