Drug-Resistant Epilepsy and Surgery

Sheng, Jiyao; Shui, Liu; Qin, Hanjiao; Li, Bingjin; Zhang, Xuewen

doi:10.2174/1570159x15666170504123316

Cited by 81 publications

(85 citation statements)

References 123 publications

(124 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to the development of new drugs, there is an increasing interest in the search for new therapeutic alternatives that enable improvements in the quality of life of patients who suffer from epilepsy, particularly those in which conventional pharmacology is not effective. In these patients, surgery and deep brain stimulation might be viable treatment options 1 – 3 . In parallel, the research and development of new neuromodulatory tools, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), focused ultrasound or the use of static magnetic fields, are of substantial importance 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey

Rivadulla

Aguilar

Coletti

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Increasing evidence indicates that static magnetic fields (SMF) reduce cortical activity in both human and animal models. The aim of this work was to investigate the effect of SMF on epileptiform cortical activity, a condition related to an abnormal increase in neuronal excitability. The first experimental block included a Pilocarpine rat model of epilepsy, in which a magnetic neodymium nickel-plated cylinder, a magnetic field of 0.5 T, or “sham” were placed over the skull. In the second experimental block, we recorded epileptic-like activity in the visual cortex of a monkey (Macaca mulatta) under control conditions and in the presence of the magnet. Between 15 and 30 minutes after the second dose of Pilocarpine, EEG changes compatible with seizure like events induced by Pilocarpine were clearly observed in the control animals (sham stimulation). Similar effects were visible in the animals exposed to the real magnet after 1–2 hours. In the monkey, SMF over the cortical focus clearly reduced abnormal activity: the intensity threshold for visual induction increased and the severity and duration decreased. These results reinforce the view that static magnets modulate cortical activity and open the door to the future therapeutic use of SMF in epilepsy as a complement to current pharmacological treatments.

show abstract

Section: Introductionmentioning

confidence: 99%

Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey

Rivadulla

Aguilar

Coletti

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Hyperexcitability resulting from disruption of the balance between excitation and inhibition in nervous tissue can trigger acute seizures [ 4 ]. Imbalances cause excessive synchrony of electrical discharges from specific neurons, thus triggering a series of abnormal behaviors [ 5 ]. Inhibitory/excitatory transmission systems play a major role in such imbalances, especially the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and the excitatory neurotransmitter glutamate [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The role of substance P in epilepsy and seizure disorders

Wang

Fan

et al. 2017

Oncotarget

Self Cite

View full text Add to dashboard Cite

A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of a specific SP receptor, neurokinin-1 receptor, were found to attenuate kainic acid (KA)-induced seizure activity. However, detailed mechanisms of SP regulation in epilepsy remain obscure. In this review, we summarize the present literature to expound the role of SP in epilepsy, and provide hypotheses for potential mechanisms.

show abstract

“…3 Recent studies have shown that up to 30% of patients who suffer from epilepsy do not respond to AEDs. 4 For these patients, several alternative treatments have been utilized, including vagal nerve stimulation, deep-brain stimulation, and ketogenic diets. 5 In some cases, surgical treatment, including surgical resection, is an option for treatment of medically intractable epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Resting‐state functional magnetic resonance imaging with independent component analysis for presurgical seizure onset zone localization: A systematic review and meta‐analysis

et al. 2020

View full text Add to dashboard Cite

Objective: One of the greatest challenges of achieving successful surgical outcomes in patients with epilepsy is the ability to properly localize the seizure onset zone (SOZ). Many techniques exist for localizing the SOZ, including intracranial electroencephalography, magnetoencephalography, and stereoelectroencephalography. Recently, resting-state functional magnetic resonance imaging (rs-fMRI) in conjunction with independent component analysis (ICA) has been utilized for presurgical planning of SOZ resection, with varying results. In this meta-analysis, we analyze the current role of rs-fMRI in identifying the SOZ for presurgical planning for patients with drug-resistant epilepsy. Specifically, we seek to demonstrate its current effectiveness compared to other methods of SOZ localization. Methods: A literature review was conducted using the PubMed, MEDLINE, and Embase databases up to May of 2020. A total of 253 articles were screened, and seven studies were chosen for analysis. Each study was analyzed for SOZ localization by ground truth, SOZ localization by rs-fMRI with ICA, principal component analysis, or intrinsic connectivity contrast, and outcomes of surgery. A meta-analysis was performed to analyze how ground truth compares to rs-fMRI in SOZ localization. Results: The odds ratio comparing ground truth to rs-fMRI was 2.63 (95% confidence interval = 0.66-10.56). Average concordance of rs-fMRI SOZ localization compared with ground truth localization across studies was 71.3%. Significance: In the hunt for less invasive presurgical planning for epilepsy surgery, rs-fMRI with ICA provides a promising avenue for future standard practice. Our preliminary results show no significant difference in surgical outcomes between traditional standards of SOZ localization and rs-fMRI with ICA. We believe that rs-fMRI could be a step forward in this search. Further investigation comparing rs-fMRI to traditional methods of SOZ localization should be conducted, with the hope of moving toward relying solely on noninvasive screening methods.

show abstract

Drug-Resistant Epilepsy and Surgery

Cited by 81 publications

References 123 publications

Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey

Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey

The role of substance P in epilepsy and seizure disorders

Resting‐state functional magnetic resonance imaging with independent component analysis for presurgical seizure onset zone localization: A systematic review and meta‐analysis

Contact Info

Product

Resources

About