Drug-resistant tuberculosis in Cuba. Results of the three global projects

Montoro, Ernesto; Lemus, Dihadenys; Echemendía, Miguel; Armas, Luisa; E, González Ochoa; Llanés, María Josefa; Valdivia, José A.

doi:10.1016/j.tube.2006.01.013

Cited by 11 publications

(9 citation statements)

References 5 publications

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“…This is different from what was obtained in Cuba during 1999-2000 where 0.5% of MDR-TB was obtained (24). The relationship between history of receiving anti-TB treatment and drug resistance has been clearly described (25).…”

Section: Discussionmentioning

confidence: 68%

Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

Green

Obi

Nchabeleng

et al. 2010

J Health Popul Nutr

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Multidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. The prevalence of drug resistance in Mycobacterium tuberculosis (MTB) isolates (n=692) from Mpumalanga province was assessed. In total, 692 (64%) MTB strains from cases with pulmonary TB were tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960 instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs. Resistance to one drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. The prevalence of MDR-TB ranged from 6.7% for three drugs to 34% for four drugs, with significant predictors being patients' age-groups of 25-54 years (p=0.0012) and >55 years (p=0.007). The result showed a high level (58.4%) of MDR-TB from cases in Mpumalanga province. To achieve a higher cure rate in this province, drug-susceptibility tests must be done for every case.

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Section: Discussionmentioning

confidence: 68%

Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

Green

Obi

Nchabeleng

et al. 2010

J Health Popul Nutr

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“…(1) In the Caribbean, rates of MDR-TB range from < 1% of new cases in Cuba to 6.6% in the Dominican Republic. (10,11) Due to the limited data on drug resistance, the World Health Organization has not provided a definitive assessment of trends of MDR-TB over time globally or in the Americas. It is hoped that with recent advances in molecular techniques, more drug resistance data will be forthcoming and the WHO will be able to determine if the prevalence of MDR-TB is increasing.…”

Section: Introductionmentioning

confidence: 99%

Multidrug-resistant tuberculosis in Port-au-Prince, Haiti

Ocheretina¹,

Morose²,

Gauthier³

et al. 2012

Rev Panam Salud Publica

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Objectives Determine the prevalence of MDR-TB among patients with new smear-positive pulmonary TB in Port au Prince, Haiti Methods Sputum samples were cultured from 1006 patients diagnosed with new tuberculosis in 2008. The core region of the rpoB gene that is associated with resistance to rifampin was sequenced. All isolates with rpoB mutations were sent to the NY State reference laboratory for conventional drug susceptibility testing (DST). All isolates were also tested with the GenoType MTBDRplus line probe assay. Results M.tubercuosis was isolated from 906 patients. 26 (2.9%) of the isolates had mis-sense mutations or deletions in rpoB and were resistant to rifampin by DST. All 26 were also resistant to isoniazid and classified as MDR-TB. 46 control isolates without rpoB mutations were all found to be rifampin-sensitive by DST. The GenoType MTBDRplus line probe assay correctly identified 26 MDR-TB strains. It misclassified 1 pansusceptible isolate as RIF-resistant. Conclusions This study shows an MDR-TB prevalence of 2.9% in newly diagnosed TB patients in Haiti and also suggests that rpoB sequencing or hybridization assays are good screening tools for early detection of MDR-TB.

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“…Como está descrito en la literatura (7,(14)(15)(16)(17)(18)(19)(20) en el presente estudio se documentó el antecedente de tratamiento previo como factor de riesgo para el desarrollo de TB MDR, OR 56.2 (IC 95 % 10,03; 314,79).…”

Section: Discussionunclassified

“…En un estudio realizado en New York se encontraron los siguientes factores de riesgo para TB MDR en inmigrantes (7): Tratamiento previo (OR ajustado 8,37), Sexo feminino (OR ajustado 3,02) y tiempo de residencia en EE.UU, Menos de 5 años (OR ajustado 15,16) vs más de 5 años (OR ajustado 4,10). En Colombia se realizó un estudio sobre factores de riesgo asociados con fracaso al tratamiento antituberculoso, sin realizar pruebas de susceptibilidad a antimicrobianos, con los siguientes hallazgos (8): Sexo masculino (OR=5,23), Atención en Instituciones privadas de salud (OR=6,67), Pertenecer a familia no nucleada (OR=8, 19), Atención en Instituciones públicas de salud (OR=0.13). Adicionalmente se publicó un estudio en donde se evaluaban factores asociados con TB Genotipo Beijing y se encontró asociación con TB MDR (OR 38,31), sexo femenino (OR 2,93) y residencia en Buenaventura (OR 5,75) (9).…”

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