Drug-Resistant Tuberculosis in HIV-Infected Persons: Italy 1999?2000

Vanacore, Paola; Koehler, Barbara; Carbonara, Santa; Zacchini, F; Bassetti, Dante; Antonucci, Giorgio; Ippolito, Giuseppe; Girardi, Enrico

doi:10.1007/s15010-004-3127-8

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…In developed countries, many publications in recent years have focused on the phenomenon of M. tuberculosis resistance to anti-TB drugs with an emphasis on variations in prevalence rates and regional profiles [3][4][5][6][7][8][9]. The elevated prevalence rates of anti-TB drug resistance (both primary and multi-resistance), which have been reported in the countries that comprised the former Soviet Union, particularly in confined populations such as in prisons, currently constitute one of the most important issues in public health worldwide [10,11].…”

mentioning

confidence: 99%

Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia

Matos¹,

Lemos²,

Bittencourt³

et al. 2007

Braz J Infect Dis

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Anti-tuberculosis drug resistance, particularly multiresistance, is a crucial issue in the control of tuberculosis (TB). This study estimated the prevalence of primary and acquired anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from hospitalized patients, to identify the risk factors for resistance, and to evaluate the its impact on hospital mortality for tuberculosis. Strains of Mycobacterium tuberculosis from 217 patients hospitalized for TB were analyzed. Subjects were recruited sequentially at a TB reference hospital in Salvador, Bahia, Brazil from July 2001 to July 2003. Multiresistant (MR) strains were defined as strains resistant to rifampicin and isoniazid. Of a total of 217 strains isolated, 41 (19.0%, 95%CI: 14.1-24.5%) were resistant to at least one drug. Prevalence of primary resistance was 7.0% (10/145), while a prevalence of 43.1% (31/72) was found for acquired resistance. Primary resistance to one drug alone was found in 2.1% (3/145) and acquired monoresistance in 5.6% (4/72). Prevalence of MR strains in general was 14.3% (31/217), of which 4.2% (6/145) consisted of primary MR and 34.7% (25/72) of acquired MR. Three strains showed resistance to more than one drug, but were not classified as MR. In the multivariate analysis, abandoning treatment remained strongly associated with resistance (adjusted OR: 7.21; 95%CI: 3.27-15.90; p<0.001) following adjustment for 3 potential confounders (gender, alcohol dependence and HIV-infection). An association was found between resistance and mortality from tuberculosis, even after adjustment for HIV status, age, sex and alcohol dependence (adjusted OR: 7.13; 95%CI: 2.25-22.57; p<0.001). High prevalences of resistance, principally acquired resistance including MR, were found in patients hospitalized for TB in Bahia. This finding was strongly associated with having abandoned treatment, and confirmed the need to standardize the procedure for requesting sensitivity tests in this population at the time of hospital admission.

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confidence: 99%

Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia

Matos¹,

Lemos²,

Bittencourt³

et al. 2007

Braz J Infect Dis

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“…Prevalence rates of DR and MDR were 14.5 and 2.6% among new cases and 30.4 and 12.5% among previously treated cases, respectively. No statistically significant risk factors associated with DR or MDR-TB emerged in the analysis (Vanacore et al, 2004).…”

Section: Italymentioning

confidence: 82%

Antimicrobial Resistance and Implications for the Twenty-First Century

2008

Emerging Infectious Diseases of the 21st Century

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“…Em um estudo multicêntrico visando avaliar a eficácia dos regimes terapêuticos para TBMR foi observado que o tratamento irregular ou incompleto foi o indicador mais importante da multirresistência (DALCOLMO et al, 1999). Outros fatores como a presença de cavitações na radiologia, e a co-infecção com HIV também parecem ser importantes para o desenvolvimento das formas resistentes (GRANICH et al, 2005;VANACORE et al, 2004). Entretanto, no Brasil, a taxa de co-infecção em pacientes com HIV/aids tem sido estimada em 3-4% dos casos.…”

Section: Introdução -Controle Da Tuberculoseunclassified

Tuberculosis and multi-drug resistant tuberculosis: immunologic mechanisms and tools for controlling the disease

Pinheiro

Dalcolmo²,

Sampaio³

2008

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Drug-Resistant Tuberculosis in HIV-Infected Persons: Italy 1999?2000

Abstract: High prevalence rates of DR and MDR are present among HIV-infected TB patients in Italy, in particular among previously treated cases.

Cited by 7 publications

References 13 publications

Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia

Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia

Antimicrobial Resistance and Implications for the Twenty-First Century

Tuberculosis and multi-drug resistant tuberculosis: immunologic mechanisms and tools for controlling the disease

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