Drug Solubilization and Stabilization by Cyclodextrin Drug Carriers

Host-Guest Interactions of α−Mangostin with (α,β,γ)−Cyclodextrins: Semi-Empirical Quantum Mechanical Methods of PM6 and PM7

“…8 CDs have been used as excipients of pharmaceutical dosages especially for lipophilic drugs sin order to enhance the solubility, stability and bioavailability due to their non-toxic and low immunogenicity properties. 9,10 US-FDA approved CD in various dosage forms including α−CD as powder for injection, β−CD for oral and topical delivery and γ−CD for intravenous injection as solution. 11 CD can make a complex with both organic and inorganic lipophile molecules so it has been widely used as functional material in pharmaceutical dosage based drug delivery system.…”

Smart medical textiles based on cyclodextrins for curative or preventive patient care

“…Indeed, in aqueous solution, the hydrophobic cavity of -, and -CD contains about 2, 6 or 9 poorly held water molecules which can be easily displaced to accommodate hydrophobic molecules (e.g. aroma compounds or lipophilic drugs, Uekama et al 1998, Loftsson & Brewster, 2013. For instance, -CD forms inclusion complexes with aliphatic residues (e.g.…”

Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI

“…CDs are also used in analytical separations and in food and cosmetic technology (Szejtli, 1998(Szejtli, , 2004. The mechanism leading to these favorable properties is primarily molecular encapsulation, although recent studies have proposed that inclusion is only a part of more complex phenomena involving also external interactions among the components and aggregation, phenomena which cannot be readily quantified (Kurkov and Loftsson, 2013;Loftsson and Brewster, 2013).…”