Drug Stability and Degradation Studies

Zhou, Deliang; Porter, William R.; Zhang, Geoff G. Z.

doi:10.1016/b978-0-444-53242-8.00005-9

Cited by 8 publications

(3 citation statements)

References 74 publications

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“…A system involving numerous proteins and cells such as neutrophils, macrophages, killer T cells, and various cytokines has been established in the immune system of the living body to contribute to infection defense. 20 − 23 Neutrophils and macrophages, the center of the immune system, phagocytose foreign pathogenic viruses that have infiltrated the body and use reactive oxygen species (ROS) to oxidize and decompose them. Thus, the superoxide radical anion (O 2 •– ), the center of the ROS family in the terminal of the immune mechanism, is produced and oxidatively decomposes foreign substances such as viruses.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer

Nakayama

Honda

2021

ACS Omega

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Electrochemical analyses aided by density functional theory calculations were used to investigate the oxidative degradation of pyrazine antiviral drugs, 3-hydroxypyrazine-2-carboxamide (T-1105) and 6-fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir, T-705), by the electrogenerated superoxide radical anion (O 2 •– ). T-1105 and T-705 are antiviral RNA nucleobase analogues that selectively inhibit the RNA-dependent RNA polymerase. They are expected as a drug candidate against various viral infections, including COVID-19. The pyrazine moiety was decomposed by O 2 •– through proton-coupled electron transfer (PCET). Our results show that its active form, pyrazine-ribofuranosyl-5′-triphosphate, is easily oxidized under inflamed organs by overproduced O 2 •– through the PCET mechanism in the immune system. This mechanistic study implies that the oxidative degradation of pyrazine derivatives will be prevented by controlling the PCET through simple modification of the pyrazine structure.

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Section: Introductionmentioning

confidence: 99%

Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer

Nakayama

Honda

2021

ACS Omega

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“…In these decision-making problems, decision makers not only assess all the indicators of evaluation objects, but also estimate the familiarity with the given results. Therefore, Zhu et al [15] presented the concept of 2-dimension linguistic assessment information to solve this kind of decision making problems. Liu et al [16]extended 2-dimension linguistic information to deal with the multiple attribute group decision making problems with unknown weight.…”

confidence: 99%

“…Aggregation operators is a hot topic. 2-dimension uncertain linguistic power generalized weighted aggregation operator is proposed and some properties are discussed [15]. 2-dimension uncertain linguistic generalized hybrid weighted average operator is proposed and employed in technological innovation ability evaluation [17].…”

confidence: 99%

A Multiple Attribute Group Decision Making Method Based on 2-D Uncertain Linguistic Weighted Heronian Mean Aggregation Operator

Liu

Liu²

2017

INT J COMPUT COMMUN

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2-Dimension uncertain linguistic variables can describe both subjective evaluation result of attributes and reliability of the evaluation results in multiple attribute decision making problems. However, it is difficult to aggregate these evaluation information and give comprehensive results. Heronian mean (HM) has the characteristic of capturing the correlations between aggregated arguments and is extended to solve this problem. The 2-dimension uncertain linguistic weighted HM aggregation(2DULWHMA) operator is employed in this paper. Firstly, the definition, properties, expectations and the operational laws the 2-dimension uncertain linguistic variables are investigated. Furthermore, the properties of the 2DULWHMA operators, such as commutativity, idempotency and monotonicity, etc. are studied. Some special cases of the generalized parameters in these operators are analyzed. Finally, an example is given to demonstrate the effectiveness and feasibility of the proposed method.

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Nanocomposites of Poly(L‐Lactic Acid) and Maghemite for Drug Delivery of Caffeine

Vargas

Souza

2011

Biomaterials Science — Processing, Properties, and Applications

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Drug Stability and Degradation Studies

Cited by 8 publications

References 74 publications

Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer

Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer

A Multiple Attribute Group Decision Making Method Based on 2-D Uncertain Linguistic Weighted Heronian Mean Aggregation Operator

Nanocomposites of Poly(L‐Lactic Acid) and Maghemite for Drug Delivery of Caffeine

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