Drug susceptibility of rapid and slow growing non-tuberculous mycobacteria isolated from symptomatics for pulmonary tuberculosis, Central India

Abstract

Drug sensitivity of NTM varies from species to species. While amikacin was the best for rapidly growing mycobacteria, clarithromycin was the most active drug against M. avium and other slow growers.

Prevalence and Antimicrobial Susceptibility of Non-tuberculous Mycobacteria Isolated from Sputum Samples of Patients with Pulmonary Infections in China

“…We showed that 100% of the M. xenopi (n = 4) isolates were susceptible to streptomycin and amikacin; M. chelonae isolates (n = 2) were susceptible to ethambutol, streptomycin, and amikacin; M. fortuitum isolates (n = 11) were susceptible to amikacin, and Mycobacterium gordonae isolates (n = 2) were susceptible to streptomycin. Another study from India reported that the majority (95.2%) of the M. fortuitum isolates were susceptible to amikacin, which is similar to our findings (22). In our study, 100% of the M. fortuitum and M. chelonae isolates were susceptible to amikacin, which is in complete agreement with that reported in India and Taiwan (22,31).…”

“…Another study from India reported that the majority (95.2%) of the M. fortuitum isolates were susceptible to amikacin, which is similar to our findings (22). In our study, 100% of the M. fortuitum and M. chelonae isolates were susceptible to amikacin, which is in complete agreement with that reported in India and Taiwan (22,31). Similar to our findings, two other studies reported that 100% of the M. fortuitum isolates were susceptible to amikacin (32,33).…”

“…Mycobacterium celonae (n = 2) 1 (50) 1 (50) 0 (0.0) 0 (0.0) 0 (0.0) 2 (100) 2 ( 100) Goswami et al (22) from India reported M. fortuitum (4.61%) as the predominant species identified, although not predominant, while our study reported a higher rate (8.5%) of M. fortuitum. Cowman et al (23) from the United Kingdom reported that M. abscessus was the predominant species identified among the younger age group, followed by M. avium complex and M. chelonae, while M. avium complex was the most predominant species identified in older age groups, followed by M. fortuitum, and Mycobacterium xenopi (23).…”

“…Due to the lack of definitive evidence on the transmission of NTM from one person to another, NTM has gained lower public health priority than tuberculosis (4). Due to the existing burden of M. tuberculosis in several countries and the limited availability of rapid molecular methods, NTM is considered extremely low priority organisms (22). Besides, NTM is often misdiagnosed as MDR TB, and is being treated with anti-tuberculosis drugs such as isoniazid and rifampicin.…”

Transition metal complexes of a dihydroquinazoline-containing ligand: synthesis, crystal structures and physical properties

“…Over the past few years, much work has been reported [17][18][19] on hydrazone Schiff base ligands obtained by the reaction of aldehydes with 2-aminobenzoylhydrazide . Recently, it has been shown that the condensation of 2-ABH with aromatic and heterocyclic aldehydes yields ring-closed quinazolinone derivatives [20][21][22][23][24].…”