Drug synthesis from natural products: a historical overview and future perspective

Prakash, Bhanu; Kujur, Anupam; Yadav, Amrita

doi:10.1016/b978-0-08-102071-5.00002-7

Cited by 15 publications

(12 citation statements)

References 93 publications

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Section: Introductionmentioning

confidence: 99%

“…Natural products are a great source of biologically active compounds to which terrestrial plants primarily contribute and have been used extensively in the traditional medicinal system for the treatment of various ailments. 1 Anthocyanins are classified under the flavonoid group, a subclass of the polyphenol family with more than 700 different anthocyanins having been identified. 2 Anthocyanins are also the most utilized colorant in the food industry, give rise to the red, blue, and purple colors of various vegetables, fruits, flowers, and leaves, and exhibit many useful bioactivities.…”

Section: ■ Introductionmentioning

confidence: 99%

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Effect of Organic Solvents and Water Extraction on the Phytochemical Profile and Antioxidant Activity of Clitoria ternatea Flowers

Jeyaraj

Lim

Choo

2021

ACS Food Sci. Technol.

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Different extraction methods (organic solvent and water extraction with the assistance of heat or ultrasound) were investigated for their effects on the phytochemical profile and antioxidant activity of Clitoria ternatea flowers. For solvent extraction (30%, 50%, 80%, or 100% methanol, ethanol, or acetone), 50% ethanol was considered to be the best solvent for the extraction with an extract yield of 57.3%, a total anthocyanin content of 5.1 mg of cyanidin 3-glucoside equivalent/g of dry weight of extract, and a total phenolic content of 59.4 mg of gallic acid equivalent/g of dry weight of extract. Similar results were obtained for the best water extract at 50 °C for 1 h. A larger number of phytochemicals were identified using LC-MS analysis in the solvent extract (28 compounds). Kaempferol hexosyl-rhamnosyl-rhamnoside was the major compound detected in both the solvent and the water extract. Both extracts showed equally potent antioxidant activity in chemical [IC 50 = 1.24 ± 0.05 (solvent extract) and 1.18 ± 0.07 (water extract) mg/mL in the 2,2-diphenyl-1-picryl-hydrazyl-hydrate assay] and cellular (75−80% inhibition) antioxidant assays.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Effect of Organic Solvents and Water Extraction on the Phytochemical Profile and Antioxidant Activity of Clitoria ternatea Flowers

Jeyaraj

Lim

Choo

2021

ACS Food Sci. Technol.

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“…Since the barriers of these rotations are not large (Table 1), it lead to registration of spectra from both conformers and to broadening of the spectrum lines. According to 1 H NMR spectra the ratio of conformers is 2:3. For alkaloids derivatives with adamantane fragment this phenomenon is not observed in the NMR spectra, since the adamantane fragment is symmetrical relative to the N-C(O) bond.…”

Section: Scheme 1 Synthesis Of Anabasine and Cytisine Amides With 12-...mentioning

confidence: 99%

Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives With Adamantane, Pyridine and 1,2-azole Fragments

Zhasymbekova¹,

Zhumagalieva²,

Seidakhmetova³

et al. 2022

Preprint

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A series of N-acyl derivatives of anabasine and cytisine were prepared to discover novel natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while adamantane derivatives showed the greatest antiviral effect. It was found that the majority of anabasine derivatives showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid. The presence of a high level of antimicrobial and antiviral activity in newly synthesized compounds makes it possible to consider them promising for further study of their pharmacological properties.

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“…O alcaloide quinino, constituinte químico presente nas cascas, foi isolado e reconhecido em meados de 1820 e 1880, respectivamente (HEINRICH, 2013). A casca destas plantas é bastante utilizada desde a antiguidade para o tratamento da febre, principalmente pelos povos da Região Amazônica (BUSS et al, 1995;PRAKASH, 2018).…”

Section: Introductionunclassified

Contribuições Farmacológicas Do Gênero Cinchona Através De Uma Revisão Bibliográfica

Sá¹,

Nascimento²,

Barbosa³

et al. 2021

Saúde Pública No Século Xxi

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Drug synthesis from natural products: a historical overview and future perspective

Cited by 15 publications

References 93 publications

Effect of Organic Solvents and Water Extraction on the Phytochemical Profile and Antioxidant Activity of Clitoria ternatea Flowers

Effect of Organic Solvents and Water Extraction on the Phytochemical Profile and Antioxidant Activity of Clitoria ternatea Flowers

Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives With Adamantane, Pyridine and 1,2-azole Fragments

Contribuições Farmacológicas Do Gênero Cinchona Através De Uma Revisão Bibliográfica

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