Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

Salvati, Anna; Poelstra, Klaas

doi:10.3390/pharmaceutics14010217

Cited by 7 publications

(2 citation statements)

References 177 publications

(223 reference statements)

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“…Over the past years a range of new developments in the field of drug delivery has emerged. Advanced drug delivery systems and nanomedicines have been designed and a few of them made it to the market [18][19][20][21]. Examples of such advanced drug delivery systems are liposomal medicinal products, nanocapsules, antibody-drug conjugates, polymer-drug conjugates (e.g.…”

Section: New Developments and Advanced Drug Delivery Systemsmentioning

confidence: 99%

Biopharmaceutics

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Touw

et al. 2023

Practical Pharmaceutics

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Biopharmaceutics, in connection with pharmacokinetics, is the field that investigates and describes everything that happens with a medicinal product and the active substance between the moment of administration, the moment it exerts its action and the moment it is eliminated from the body. Biopharmaceutics connects the physico-chemical properties of an active substance and its dosage form, especially through the drug release characteristics, with its fate and action in the living organism. Actually biopharmaceutics describes how medicine formulation technologies can affect pharmacokinetics and pharmacodynamics. The route of administration, the way the active substance is released from the dosage form, and the way the body handles (absorbs, distributes, metabolises and excretes) the active substance, together determine its (duration of) action, its efficacy and the occurrence of adverse effects. This chapter explains general principles of biopharmaceutics and its relation to pharmacokinetics in the light of their implications on the design of medicines. It describes the general biopharmaceutical principles that are relevant to the major routes of administration: parenteral, oromucosal, oral, rectal, dermal, nasal, pulmonary and ocular. Topics discussed include solubility and dissolution, bioavailability, partition coefficient and pH partition theory, the biopharmaceutical classification system (BCS), excipient-, food-, drug-and herb-drug interactions, first-pass effects and drug metabolism, bioequivalence and new developments in the field of advanced drug delivery systems. What Is New?Minor parts of the chapter have been revised. Attention is given to new developments. Learning ObjectivesThe reader knows that:• Pharmacotherapy can only be optimal if the pharmaceutical formulation (the medicinal product) and its functionalities are appropriate for the chosen route of administration and the intended therapeutic objective. • The technical and biopharmaceutical functionalities of a medicinal product are determined by its qualitative and Based upon Chapter 16 Biopharmaceutics, in the 2015 edition of Practical Pharmaceutics.

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Section: New Developments and Advanced Drug Delivery Systemsmentioning

confidence: 99%

Biopharmaceutics

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Lagarce

Touw

et al. 2023

Practical Pharmaceutics

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“…It can also lead to the enhancement and advancement of efficient directive routes, decrease virulence factor, less side effects, proper targeted drug delivery with better distribution and increased biotransfor mation of drug as shown in the ▶Fig 1. The designed drug delivery mechanisms are targeted to the specific receptor sites or carry the moderate release of the therapeutic compounds to the specific sites [17]. This requires the ability to overcome the resistance such as opsonisation by the macrophage system.…”

Section: Basics Of Nanotechnology Based Techniques In Designing Nanom...mentioning

confidence: 99%

Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

et al. 2022

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The rapid advancement of nanomedicine presents novel alternatives that have the potential to transform health care. Targeted drug delivery as well as the synthesis of nanocarriers is a growing discipline that has been intensively researched to reduce the complexity of present medicines in a variety of diseases and to develop new treatment and diagnostic techniques. There are several designed nanomaterials used as a delivery system such as liposomes, micelles, dendrimers, polymers, carbon-based materials, and many other substances, which deliver the drug moiety directly into its targeted body area reducing toxic effect of conventional drug delivery, thus reducing the amount of drug required for therapeutic efficacy and offering many more advantages. Currently, these are used in many applications, including cancer treatment, imaging contrast agents, and biomarker detection and so on. This review provides a comprehensive update in the field of targeted nano-based drug delivery systems, by conducting a thorough examination of the drug synthesis, types, targets, and application of nanomedicines in improving the therapeutic efficiency.

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