Drug testing in the era of new psychoactive substances

Gerona, Roy; French, Deborah

doi:10.1016/bs.acc.2022.08.001

Cited by 7 publications

(2 citation statements)

References 96 publications

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“…The report further highlights the diagnostic challenges in emergency rooms due to the existing limitations of drug-testing tools. Newer drug-testing tools cover a broader range of substances but often exclude gabapentinoids 19. Comprehensive testing for various substances, including gabapentin, can be achieved using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry 20.…”

Section: Discussionmentioning

confidence: 99%

“…Newer drug-testing tools cover a broader range of substances but often exclude gabapentinoids. 19 Comprehensive testing for various substances, including gabapentin, can be achieved using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry. 20 However, these technologies remain out of reach in many settings owing to resource…”

Section: Discussionmentioning

confidence: 99%

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Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history

Awasthi,

Vohra

2023

BMJ Case Rep

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We report about a man in his mid-50s who was prescribed pregabalin (150 mg/day) for neuropathic pain due to a herniated intervertebral disc. Four weeks later, he presented to the emergency room with symptoms consistent with delirium. After ruling out acute intoxication with a substance and neurological causes, collateral information from the family and review of his medical chart indicated potential discontinuation syndrome owing to pregabalin. Following the successful treatment and resolution of delirium, the patient revealed he had been consistently consuming pregabalin doses upwards of 2 g/day over the past 2 weeks, leading to the premature exhaustion of his prescription and an abrupt cessation. The case findings underscore the necessity for physicians to recognise the potential for pregabalin misuse and the associated withdrawal risks, including delirium.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%