Drug Therapy for Acute Pancreatitis

Bi, Yan; Atwal, Tegpal; Vege, Santhi Swaroop

doi:10.1007/s11938-015-0058-7

Cited by 12 publications

(9 citation statements)

References 111 publications

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“…Despite a significant amount of research over the last few decades with a greater understanding of the pathophysiology of AP, there are few specific drugs used for the treatment of SAP [5]. These include the clinical use of protease inhibitors such as ulinastatin and somatostatin; however, their therapeutic effect is still doubtful [28].…”

Section: Discussionmentioning

confidence: 99%

“…Despite a significant understanding of the pathophysiology of AP over the last few decades, there are only a few drugs used for the treatment, which includes anti-secretory agents, protease inhibitors, antioxidants, non-steroidal anti-inflammatory drugs, platelet activation factor antagonists, probiotics, and activated protein C [5]. However, the efficiency is not satisfactory, and the recommended management is limited to supportive care such as fluid, nutrition, and treatment of complications.…”

Section: Introductionmentioning

confidence: 99%

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Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

Cen

Liu

et al. 2016

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

Cen

Liu

et al. 2016

International Immunopharmacology

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“…There are other experimental models used to reproduce human AP, for example, L-arginine model can parallel severe, bile salt-induced pancreatitis. 64) Alcohol abuse is a primary cause of both acute and chronic pancreatitis, [65][66][67] the combination of alcohol exposure and endotoxemia is a well-established experimental protocol to trigger pancreatitis. 52) Thus, further studies of the protective effects of spautin-A41 on different pancreatitis models are urgently needed.…”

Section: Discussionmentioning

confidence: 99%

Spautin-A41 Attenuates Cerulein-Induced Acute Pancreatitis through Inhibition of Dysregulated Autophagy

Dong

Xia

Xie

et al. 2019

Biological & Pharmaceutical Bulletin

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Autophagy plays key roles in the development of acute pancreatitis (AP) and the regulation of impaired autophagy has therapeutic potential. The objective of the present study was to investigate whether pharmacological inhibition of autophagy could ameliorate AP in mice and examine the underlying mechanisms. In current study, by imaging-based high-throughput screening, a novel spautin-1 derivative spautin-A41 was identified as a potent autophagy inhibitor. Mice treated with spautin-A41 were resistant to the cerulein-induced elevation of serum pancreatic enzyme activities and pancreatic apoptosis. Mechanistically, spautin-A41 effectively reduced the expression levels of Class III phosphatidylinositol 3 (PI3) kinase complexes and subsequently ameliorated pancreatitis by inhibiting the formation of autophagosome. Therefore, pharmacological inhibition of autophagy by spautin-A41 may serve as new target for treating or lessening the severity of AP.

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“…Severe acute pancreatitis (SAP) is a serious illness with rapid onset and a high fatality rate. It is characterized by the systemic inflammatory response syndrome, the multiple organ dysfunction syndrome, sepsis, and other complications (Bi et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Porous COS@SiO2 Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice

et al. 2020

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Severe acute pancreatitis (SAP) is associated with high rates of mortality and morbidity. Chitosan oligosaccharides (COSs) are agents with antioxidant properties. We developed porous COS@SiO 2 nanocomposites to study the protective effects and mechanisms of COS nanomedicine for the treatment of acute pancreatitis. Porous COS@SiO 2 nanocomposites released COSs slowly under pH control, enabling sustained release and maintaining the drug at a higher concentration. This study aimed to determine whether porous COS@SiO 2 nanocomposites ameliorate SAP and associated lung injury. The SAP model was established in male C57BL/6 mice by intraperitoneal injection of caerulein. The expression levels of myeloperoxidase, malondialdehyde, superoxide dismutase, nuclear factor-kappa B (NF-κB), the NOD-like receptor protein 3 (NLRP3) inflammasome, nuclear factor E2-related factor 2 (Nrf2), and inflammatory cytokines were detected, and a histological analysis of mouse pancreatic and lung tissues was performed. In the SAP groups, systemic inflammation and oxidative stress occurred, and pathological damage to the pancreas and lung was obvious. Combined with porous COS@SiO 2 nanocomposites before treatment, the systemic inflammatory response was obviously reduced, as were oxidative stress indicators in targeted tissues. It was found that Nrf2 was significantly activated in the COS@SiO 2 treatment group, and the expressions of NF-κB and the NLRP3 inflammasome were notably decreased. In addition, this protective effect was significantly weakened when Nrf2 signaling was inhibited by ML385. This demonstrated that porous COS@SiO 2 nanocomposites activate the Nrf2 signaling pathway to inhibit oxidative stress and reduce the expression of NF-κB and the NLRP3 inflammasome and the release of inflammatory factors, thus blocking the systemic inflammatory response and ultimately ameliorating SAP and associated lung injury.

show abstract

Drug Therapy for Acute Pancreatitis

Cited by 12 publications

References 111 publications

Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

Spautin-A41 Attenuates Cerulein-Induced Acute Pancreatitis through Inhibition of Dysregulated Autophagy

Porous COS@SiO2 Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice

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