Drug transport in stimuli responsive acrylic and methacrylic interpenetrating polymer networks

Simeonov, Marin; Monova, Antonia; Kostova, Bistra; Vassileva, Elena

doi:10.1002/app.45380

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…This explanation is in line with the ζ potential measurements as well as with the microscopy and XRD analysis that revealed the lower DFS crystallinity in P3D compared to the other two PEC samples. Similar behavior was observed for hydrogel systems pairing anionic polymer matrix and cationic drug 32 …”

Section: Resultssupporting

confidence: 77%

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Polyelectrolyte complexes of chitosan and sodium alginate as a drug delivery system for diclofenac sodium

Nikolova

Simeonov

Tzachev

et al. 2021

Polymer International

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Polyelectrolyte complexes (PECs) have unique physicochemical properties which make them very interesting for pharmaceutical applications and particularly as drug delivery systems. The aim of this work was to obtain PECs based on the biocompatible and biodegradable biopolymers chitosan and sodium alginate and to apply them as a drug delivery system for sustained release of diclofenac sodium. Three complexes with different ratios between the two polyions were obtained. Their structure and properties were investigated using dynamic light scattering, microscopy methods (optical, scanning and transmission electron microscopy), infrared spectroscopy, X-ray diffraction. The drug entrapment efficiency of the various PECs was assessed and the release profiles were monitored. In this way the relationship between the composition of the PECs and the drug release profiles was outlined. The fibrillar form of the chitosan/alginate PECs was demonstrated to exert specific control over the diclofenac release which makes these materials appropriate as vehicles for controlled diclofenac sodium release.

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Section: Resultssupporting

confidence: 77%

“…Similar behavior was observed for hydrogel systems pairing anionic polymer matrix and cationic drug. 32…”

Section: Kinetic Study Of Drug Dissolutionmentioning

confidence: 99%

Polyelectrolyte complexes of chitosan and sodium alginate as a drug delivery system for diclofenac sodium

Nikolova

Simeonov

Tzachev

et al. 2021

Polymer International

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“…Fickian diffusion is observed when the rate of water molecules is slower than the rate of relaxation of the polymer chains, i.e., the polymer chains are very flexible and move faster as compared to water molecules. Therefore, the diffusion of water molecules into the PAAm single network is determined by their rate and is not influenced by the polymer chains, as the latter’s movements are much faster [ 29 , 30 , 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Polyacrylamide/poly(2-(dimethylamino) Ethyl Methacrylate) Interpenetrating Polymer Networks as Drug Delivery Systems for Diclofenac Sodium

Grigorova

Kostova

Georgieva

et al. 2022

Gels

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Nowadays, modern pharmaceutical investigations are directed toward the design and production of drug delivery systems for achieving prolonged and controlled drug delivery. In this respect, the use of interpenetrating polymer networks (IPNs) is an opportunity in the preparation of polymer drug delivery systems with desired characteristics. This paper describes the synthesis and characterization of novel poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) and polyacrylamide (PAAm)-based IPNs with different compositions and their application as diclofenac sodium delivery systems. The prepared IPNs were shown to possess phase-separated structures at the nano level, as revealed by SEM and TM-DSC. The IPNs’ composition was shown to determine the swelling behavior of these novel materials, and the inclusion of the charged IPN component (PDMAEMA) has changed the water molecules type diffusion from Fickian to non-Fickian, as revealed by the swelling kinetics study. Loading efficiency of diclofenac sodium and diclofenac sodium content in the polymer network was evaluated, and in vitro drug release experiments were carried out in order to estimate the ability of the obtained IPNs to control the release of the water-soluble drug.

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“…The wide range of commercial applications of polymer microspheres has encouraged research in this field during the last decade. Polymer microspheres with optimized characteristics, such as uniform size and shape, functionality of the base polymer, morphology of the polymer particles and degree of crosslinking, are widely used as functional supports, for chromatographic separation, in biomedical devices, coating additives and controlled release reservoirs, among other areas [1][2][3][4] . Size, size distribution, chemical nature and functionality are important characteristics of spherical particles 5 .…”

Section: Introductionmentioning

confidence: 99%

Influence of the Fraction of Comonomers and Diluents on the Preparation of Polymeric Microspheres Based on Poly (Methacrylic acid-co-divinylbenzene) Obtained by Precipitation Polymerization

et al. 2018

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Preparation and characterization of polymeric microspheres based on poly(methacrylic acidco-divinylbenzene) (P(MAA-co-DVB)) by precipitation polymerization are reported. The influence of the change in comonomer composition, crosslinking degree, ratio of total monomers/diluents by weight/volume (g/100 mL) and the volume ratio of diluents were studied. Spherical particles were obtained in the range from 1.42 to 8.41 µm. An increase in particle size and thermal resistance with decreasing molar fraction of methacrylic acid (MAA) were observed, associated with increases in critical chain length (CCL) and the number of crosslinks in this system, respectively. The analysis of particles with molar fraction of 50% MAA and acetonitrile/toluene volumetric ratio of 75/25 showed that larger particle size and yield were achieved with increasing ratio of total monomers/diluents (g / 100 mL). The particles prepared with 14% molar fraction of MAA obtained greater swelling ratios than the particles prepared with 50% MAA.

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Drug transport in stimuli responsive acrylic and methacrylic interpenetrating polymer networks

Cited by 7 publications

References 22 publications

Polyelectrolyte complexes of chitosan and sodium alginate as a drug delivery system for diclofenac sodium

Polyelectrolyte complexes of chitosan and sodium alginate as a drug delivery system for diclofenac sodium

Polyacrylamide/poly(2-(dimethylamino) Ethyl Methacrylate) Interpenetrating Polymer Networks as Drug Delivery Systems for Diclofenac Sodium

Influence of the Fraction of Comonomers and Diluents on the Preparation of Polymeric Microspheres Based on Poly (Methacrylic acid-co-divinylbenzene) Obtained by Precipitation Polymerization

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