Drug use among men with unfulfilled wish to father children: a retrospective analysis and discussion of specific drug classes

Pompe, Sina Vanessa; Strobach, Dorothea; Stief, Christian G.; Becker, Armin J.; Trottmann, Matthias

doi:10.1002/pds.3986

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…13 It has been estimated that among involuntary childless men that present to infertility clinics, 25% take drugs that have the potential to negatively impact male sexual function and 10% take drugs associated with male fertility impairment. 42 Furthermore, several psychosocial factors, associated with a diagnosis of IA, may have contributed to the lower fertility rate as observed in this study. 43 In our study, due to problems or concerns associated with IA and its treatment and based on medical advice (or the lack of), men with IA and their partners decided to become voluntarily childless or to delay their plans to become parents.…”

Section: Inflammatory Arthritismentioning

confidence: 65%

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Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility)

et al. 2021

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ObjectivesThe impact of inflammatory arthritis (IA) on male fertility remains unexplored. Our objective was to evaluate the impact of IA on several male fertility outcomes; fertility rate (number of biological children per man), family planning, childlessness and fertility problems.MethodsWe performed a multicentre cross-sectional study (iFAME-Fertility). Men with IA 40 years or older who indicated that their family size was complete were invited to participate. Participants completed a questionnaire that included demographic, medical and fertility-related questions. To analyse the impact of IA on fertility rate, patients were divided into groups according to the age at the time of their diagnosis: ≤30 years (before the peak of reproductive age), between 31 and 40 years (during the peak) and ≥41 years (after the peak).ResultsIn total 628 participants diagnosed with IA were included. Men diagnosed ≤30 years had a lower mean number of children (1.32 (SD 1.14)) than men diagnosed between 31 and 40 years (1.60 (SD 1.35)) and men diagnosed ≥41 years (1.88 (SD 1.14)).This was statistically significant (p=0.0004).The percentages of men diagnosed ≤30 and 31–40 years who were involuntary childless (12.03% vs 10.34% vs 3.98%, p=0.001) and who reported having received medical evaluations for fertility problems (20.61%, 20.69% and 11.36%, p=0.027) were statistically significant higher than men diagnosed ≥41 years.ConclusionsThis is the first study that shows that IA can impair male fertility. Men diagnosed with IA before and during the peak of reproductive age had a lower fertility rate, higher childlessness rate and more fertility problems. Increased awareness and more research into the causes behind this association are urgently needed.

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Section: Inflammatory Arthritismentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility)

et al. 2021

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“…It has also been shown that apart from conventional male reproductive toxicity assessment by measuring the weight of reproductive organs such as testis, epididymis and prostate, analysis of sperm motility and viability, macroscopic and histological examination and changes in hormone levels [7,8] , the protein profi le can also be used to evaluate the male reproductive toxicity [9][10][11][12] . The present study was aimed to evaluate the alterations in the sperm count, ion concentration and pattern of protein profi le in cauda and caput after treatment with VCR thus leading to compromised epididymal functions.…”

Section: Research Papermentioning

confidence: 99%

Epididymal Toxicity Associated with Vincristine Treatment

Sonawane¹,

Azaz²,

Hemant³

et al. 2019

pharmaceutical-sciences

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Sonawane et al.: Epididymal Toxicity Associated with Vincristine Vincristine, a major player in front line combination chemotherapy of cancer reduces testosterone levels contributing to reproductive toxicity. Much is known about testicular toxicity of vincristine as compared to its effect on epididymis; hence, the present study aimed to evaluate the epididymal toxicity associated with vincristine treatment, which also contributes to the overall reproductive toxicity associated with vincristine. Vincristine was intraperitoneally injected to adult male Wistar rats of proven fertility with a dose of 40 mg/kg/day dissolved in 0.5 ml of physiological saline for 30 days. The epididymal weight was found to be unaltered after treatment whereas sperm count was reduced signifi cantly. Signifi cant changes were noted in ion concentrations of cauda and caput of epididymis with changes in protein profi le of the tissue, sperm and luminal protein from cauda and caput region, which plays a signifi cant role in sperm maturation and sperm transport. Infertility associated with vincristine could be attributed to its effects on various epididymal proteins involved in sperm protection and various stages of sperm development such as cytoplasmic extrusion and membrane stabilization, which had contributed to the abnormal sperm count and impaired function.

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“…Indeed, the impact of drugs on male fertility is rather neglected. For instance, in a retrospective study, 47% of men with an unfulfilled wish to father a child took drugs, with 16% of those with a known fertility impairment and 51% with an impairment of male sexual function [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Factors Determining Quality of Drug Information by Hospital Pharmacies—Results from Five-Year Annual Quality Assessment

Strobach,

Chiriac,

Klausner

et al. 2024

Pharmacy

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Drug information (DI) provided by hospital pharmacies aims to promote rational and safe drug therapy. While quality assessment for this task is recommended, more knowledge on the factors determining the quality is needed. We aimed to evaluate the impacts of different factors on the quality of DI provided by hospital pharmacies to healthcare professionals. Retrospectively, answers on fictitious enquiries about annual DI tests for German hospital pharmacies over five years were evaluated for content-related and structural requirements. Multivariate analysis was performed for the impact of the enquiry complexity, DI organization (specialized DI center; pharmacist responsible per day; DI on top of other routine tasks), and quality measures (second look; experience of answering pharmacist in DI/on ward; use of documentation database). In 2017–2021, 45, 71, 79, 118, and 122 hospital pharmacies participated. The enquiry complexity had a statistically significant impact on the content-related quality, with poor results for a higher complexity (years 2018/2021, OR 0.25/0.04, p < 0.01). The DI centers achieved better results regarding content-related quality than for a pharmacist responsible per day (OR 0.76/p = 0.65) or DI on top of routine tasks (OR 0.35/p = 0.02). The DI centers scored better in structural quality. The second look showed an overall trend of a better content-related and structural quality. In conclusion, specialized DI centers and second looks are recommended as quality-improving measures. Training for answering complex enquiries should be intensified.

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Drug use among men with unfulfilled wish to father children: a retrospective analysis and discussion of specific drug classes

Cited by 6 publications

References 46 publications

Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility)

Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility)

Epididymal Toxicity Associated with Vincristine Treatment

Factors Determining Quality of Drug Information by Hospital Pharmacies—Results from Five-Year Annual Quality Assessment

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