Drug use by demented and non-demented elderly people

Wills, Phillipa; Claesson, Cecilia B.; Fratiglioni, Laura; Fastbom, Johan; Thorslund, Mats; Winblad, Bengt

doi:10.1093/ageing/26.5.383

Cited by 46 publications

(30 citation statements)

References 29 publications

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“…This is in agreement with Hanlon et al [46], who found that demented patients were less likely to receive analgesics than those who were cognitively intact, but that the opposite was true for central nervous system drugs. Furthermore, these results have recently been confirmed: cognitively impaired people used a greater number of antipsychotics and opioids, but less gastrointestinal agents and analgesics [47].…”

Section: Discussionmentioning

confidence: 81%

Comorbidity and Drug Use in Cognitively Impaired Elderly Living in Long-Term Care

Landi

Gambassi²,

Lapane³

et al. 1998

Dement Geriatr Cogn Disord

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Cognitive impairment is associated with an increased mortality in older people. The prevalence and impact of comorbidity on functional status and mortality of demented patients has not been fully elucidated. Using a population-based data set, we describe the prevalence of cognitive impairment, functional status, principal comorbid conditions and 1-year survival for over 300,000 patients admitted to the nursing homes in five US states. Sixty-one percent of patients have some level of cognitive impairment, and this correlates with the degree of physical frailty. Severer cognitive impairment is associated with a higher mortality rate. Yet, patients with cognitive impairment appear to have fewer comorbid conditions and are less likely to receive medications and special treatments than residents with normal cognitive status. Additional studies are needed to understand whether demented patients may paradoxically be considered healthier or, instead, are only neglected.

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Section: Discussionmentioning

confidence: 81%

Comorbidity and Drug Use in Cognitively Impaired Elderly Living in Long-Term Care

Landi

Gambassi²,

Lapane³

et al. 1998

Dement Geriatr Cogn Disord

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show abstract

“…If the participant resided in an institution, this information was provided from medical records. The different sources of information could affect the reported prevalence of drugs and diseases in the different groups, e.g., the number of drugs used by persons with dementia who lived in their own homes may be underestimated [51]. On the other hand, an advantage of using self-report is that the use of over the counter drugs (e.g., calcium/vitamin D supplements) is taken into account.…”

Section: Limitationsmentioning

confidence: 99%

Undertreatment of osteoporosis in persons with dementia? A population-based study

et al. 2011

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“…In particular, patients with Alzheimer's disease (AD) have been reported to be less likely to suffer from cardiovascular conditions, but also from pulmonary diseases, arthritis and diabetes mellitus [8][9][10]. Moreover, important differences between different types of dementia with respect to the use of specific medications may further support the hypothesis that patients with AD are less likely to have chronic medical conditions than other demented patients [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Impact of the Type and Severity of Dementia on Hospitalization and Survival of the Elderly

Landi

Gambassi²,

Lapane

et al. 1999

Dement Geriatr Cogn Disord

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We conducted a retrospective cohort study to examine whether patients with Alzheimer’s disease (AD) or vascular dementia (VaD) differed in the number and type of associated comorbid conditions. In addition, we evaluated the impact of the severity of cognitive impairment on hospitalization and mortality of patients in each group. We studied 161,106 patients over age 65, with any degree of cognitive impairment, residing in any of 1,573 Medicare/Medicaid-certified nursing homes of 5 states of the USA between 1992 and 1995. Patients were assessed with the federally mandated Minimum Data Set (MDS). The MDS has been cross-linked to Medicare eligibility files and to the Medicare Provider Analysis and Review database. AD patients were younger, and more likely to be female and Caucasian than VaD patients. For comparable levels of cognitive impairment, AD patients appeared to have fewer comorbid conditions, including those that were not risk factors for VaD. In addition, patients with AD had decreased morbidity and mortality relative to patients with VaD. These findings support the hypothesis that AD patients are a healthier group of demented patients.

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Drug use by demented and non-demented elderly people

Cited by 46 publications

References 29 publications

Comorbidity and Drug Use in Cognitively Impaired Elderly Living in Long-Term Care

Comorbidity and Drug Use in Cognitively Impaired Elderly Living in Long-Term Care

Undertreatment of osteoporosis in persons with dementia? A population-based study

Impact of the Type and Severity of Dementia on Hospitalization and Survival of the Elderly

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