Drug Use Evaluation of Ceftriaxone in Medical Ward of Mizan Aman General Hospital, Bench Maji Zone, South Western Ethiopia

Geresu, Gudeta Duga; Yadesa, Tadele Mekuriya; Deresa, Berhanu

doi:10.4172/1948-593x.1000221

Cited by 5 publications

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“…17 On the other hand, the overall inappropriate use was higher than studies conducted at Ayder Referral Hospital (64.2%), 23 Dessie Referral Hospital (46.2%), 24 Zewditu Memorial Hospital (51.1%) and Hayat General Hospital (55.4%), 25 Veteran Hospital in the United States (53%), 26 Korean Hospital (34.5%) 10 and Mizan Aman General Hospital (60.8%). 27 The inappropriate use of ceftriaxone in hospitals of Harar town was high and might be considered as a driving factor for the development and spread of resistant bacteria harboring in such settings. 28 This will impose severe financial and service burden in the hospitals and negates the therapeutic outcome.…”

Section: Discussionmentioning

confidence: 99%

“…44 However, the use of ceftriaxone as a prophylactic agent is higher in this study when compared to studies from Dessie Referral Hospital, 24 Zewditu Memorial Hospital and Hayat General Hospital, 25 Veteran hospital in the United States, 26 Gondar University Referral Hospital, 22 Felege Hiwot Referral Hospital, 21 and Mizan Aman General Hospital. 27 This might be because of the easy access to the drug and lack of other first-line options in surgical prophylaxis. 38…”

Section: Discussionmentioning

confidence: 99%

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The appropriateness of ceftriaxone utilization in government hospitals of Eastern Ethiopia: A retrospective evaluation of clinical practice

et al. 2021

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Introduction: Drug use evaluation is a method of obtaining information to identify problems related to drug use and if properly developed, a means of correcting the problems. Ceftriaxone is among the most commonly utilized cephalosporins. Owing to a broad spectrum of activity and being used empirically, ceftriaxone has been used inappropriately posing a risk for development of antimicrobial resistance. This study is, therefore, designed to evaluate the appropriateness of ceftriaxone utilization in government hospitals in Harar town. Methods: A retrospective cross-sectional study was conducted in four government hospitals of Harar town by reviewing the medical records of 271 patients who received ceftriaxone from 1 January to 31 December 2016. Systematic random sampling was utilized to capture the medical records. Data were entered and analyzed using SPSS version 22. Results: From the 271 medical records reviewed majority of patients were from surgical ward ( n = 85, 31.4%) followed by gynecology and obstetrics ward ( n = 67, 24.7%). Demographically, the majority of the patients were female ( n = 142, 52.4%). Patients in the age group of 20–29 years were dominant ( n = 98, 36.2%). A total of 71 drugs were co-administered with ceftriaxone, the most common being metronidazole followed by tramadol. Among the co-administered drugs, unfractionated heparin ( n = 6), warfarin ( n = 5), and enoxaparin ( n = 1) were found to have a moderate drug interaction with ceftriaxone. Ceftriaxone was commonly used for post-operative prophylaxis ( n = 80, 27.5%) followed by for the management of pneumonia ( n = 62, 21.3%). The result of ceftriaxone use evaluation showed that majority ( n = 190, 70.1%) were found to be inappropriate. The inappropriate utilization was primarily due to wrong indication (indications for which ceftriaxone was not the primary option) ( n = 114, 60.0%) followed by wrong duration ( n = 54, 28.4%). Conclusion: Ceftriaxone was used inappropriately in more than two-thirds of the patients, with wrong indication and wrong duration contributing the majority. Inappropriate use of antibiotics may potentially lead to the emergence and spread of drug-resistant microorganisms and also ultimately exposes the patient to treatment failure, prolonged hospital stay, and higher cost of therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The appropriateness of ceftriaxone utilization in government hospitals of Eastern Ethiopia: A retrospective evaluation of clinical practice

et al. 2021

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“…Ceftriaxone misuse is mostly brought on by medical practitioners' inadequate understanding of pharmacology and pathophysiology, their inability to make a proper diagnosis, and their unwillingness to choose the most effective and reasonable course of action [12]. Antimicrobial resistance and negative medication reactions could result from this and the length of hospitalization and delay in successful therapy are also ceftriaxone's other side effects [13]. Drug use evaluation (DUE) involves a thorough review of patient prescription and medication data before, during, and after dispensing in order to ensure appropriate therapeutic decision-making and patient outcome and also it is an ongoing systematic process designed to maintain the appropriate and effective use of drugs [14].…”

Section: Introductionmentioning

confidence: 99%

Retrospective Drug use Evaluation of Ceftriaxone In Resource Limited Setting In Case Of Bedele General Hospital, Ethiopia

Jifar¹,

Adugna²,

Gadisa³

et al. 2022

Preprint

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Background: Anti-microbial resistance (AMR) due to the over use of the reserved antibiotics like ceftriaxone is one of the threatening global issues of public health and many patients suffer due to harms arising from AMR because the infections caused by viruses, bacteria, fungi, protozoa and helminthes are no longer susceptible to the commonly available antibiotics. Objective: To evaluate the utilization pattern of ceftriaxone at Medical Ward in Bedele General Hospital, Bedele, South West Oromia, Ethiopia. Methodology: Patients' medical record cards (PMRCs) from the medical ward at Bedele General Hospital who took ceftriaxone between July 1 and December 30 of 2021 were the subject of a hospital-based retrospective cross-sectional study design and the selection of the medical record cards was done using a systemic random sample technique. Utilizing current Ethiopia's Standard Treatment Guideline for General Hospital and Drug Use Evaluation Criteria, the appropriateness of the ceftriaxone usage was assessed. Results: A total of 212 patients’ medical records were reviewed and the most frequent age group was adults in the range of 18-65 (80.5%) and the use of ceftriaxone was inappropriate in 185 cases (47.1%). Ceftriaxone was mainly used for the treatment of pneumonia condition (46.2%), regarding ceftriaxone dosage in our study, the majority of patients received 2 g/day (85.4%) and the mean duration of ceftriaxone therapy in our study was 11.47 days, with a range of 2-7 days (49.7%). Maintenance fluids were the most commonly co-administered medications with a frequency of 32.9%. Conclusions: Prescribers should follow the national standard treatment guideline in order to increase rational use of ceftriaxone and stop the emergence of resistance. The hospital may choose to implement antimicrobial control systems and short-term training for health care professional in order to adhere the treatment guideline is our recommendation.

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Inappropriate ceftriaxone utilization and predictor factors in Ethiopia: a systematic review and meta-analysis

Tafere,

Endeshaw,

Demsie

et al. 2024

Sci Rep

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Ceftriaxone stands as a cornerstone in global antibiotic therapy owing to its potent antibacterial activity, broad spectrum coverage, and low toxicity. Nevertheless, its efficacy is impeded by widespread inappropriate prescribing and utilization practices, significantly contributing to bacterial resistance. The aim of this study is to determine the overall national pooled prevalence of inappropriate ceftriaxone utilization and its predictor factors in Ethiopia. A systematic search was conducted across multiple databases including, PubMed, Science Direct, Hinari, Global Index Medicus, Scopus, Embase, and a search engine, Google Scholar, to identify relevant literatures that meet the research question, from March 20 to 30, 2024. This meta-analysis, which was conducted in Ethiopia by incorporating 17 full-text articles, unveiled a national pooled inappropriate ceftriaxone utilization of 55.24% (95% CI, 42.17%, 68.30%) with a substantial heterogeneity index (I2 = 99.24%, p value < 0.001). The review has also identified predictive factors for the inappropriate use of ceftriaxone: empiric therapy (AOR 21.43, 95% CI; 9.26–49.59); multiple medication co-prescription (AOR: 4.12, 95% CI; 1.62–8.05). Emergency ward (AOR: 4.22, 95% CI; 1.8-12.24), surgery ward (AOR: 2.6, 95% CI; 1.44–7.82) compared to medical ward, prophylactic use (AOR: 500, 95% CI; 41.7–1000), longer hospital stay-8-14 Days; (AOR: 0.167, 95% CI; 0.09–0.29), > 14 days; (AOR: 0.18, 95% CI; 0.1–0.32). The study reveals a high national pooled prevalence of inappropriate ceftriaxone utilization, standing at 55.24%, highlighting a significant hazard in the use of this antibiotic. This could be attributed to instances of overuse, misuse or prescription practices that deviates from established guidelines. This eminent challenge can lead to the development of antibiotic resistance, increased healthcare costs, adverse drug reactions, and treatment failures, necessitating multifaceted approach such as improved antibiotic stewardship, better adherence to guidelines, and enhanced clinician education on appropriate antibiotic use. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-75728-z.

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Drug Use Evaluation of Ceftriaxone in Medical Ward of Mizan Aman General Hospital, Bench Maji Zone, South Western Ethiopia

Cited by 5 publications

References 0 publications

The appropriateness of ceftriaxone utilization in government hospitals of Eastern Ethiopia: A retrospective evaluation of clinical practice

The appropriateness of ceftriaxone utilization in government hospitals of Eastern Ethiopia: A retrospective evaluation of clinical practice

Retrospective Drug use Evaluation of Ceftriaxone In Resource Limited Setting In Case Of Bedele General Hospital, Ethiopia

Inappropriate ceftriaxone utilization and predictor factors in Ethiopia: a systematic review and meta-analysis

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