Drug use in pregnancy—physicians’ evaluation of quality and clinical impact of drug information centres

Widnes, Sofia Kristina Frost; Schjøtt, Jan

doi:10.1007/s00228-008-0593-4

Cited by 19 publications

(31 citation statements)

References 22 publications

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“…This suggests a clear risk of unnecessary use of medicines, misunderstandings, and groundless anxiety that could be avoided by the deployment of relevant, uniform, and accurate information. It has been argued that teratology information services (TIS) are effective in teratology information knowledge transfer by using evidence-based information expressed in lay language [26-28]. These TIS exist all over North America, in Australia, and many European countries.…”

Section: Discussionmentioning

confidence: 99%

Multiple Information Sources and Consequences of Conflicting Information About Medicine Use During Pregnancy: A Multinational Internet-Based Survey

Hämeen‐Anttila¹,

Nordeng²,

Kokki³

et al. 2014

J Med Internet Res

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BackgroundA wide variety of information sources on medicines is available for pregnant women. When using multiple information sources, there is the risk that information will vary or even conflict.ObjectiveThe objective of this multinational study was to analyze the extent to which pregnant women use multiple information sources and the consequences of conflicting information, and to investigate which maternal sociodemographic, lifestyle, and medical factors were associated with these objectives.MethodsAn anonymous Internet-based questionnaire was made accessible during a period of 2 months, on 1 to 4 Internet websites used by pregnant women in 5 regions (Eastern Europe, Western Europe, Northern Europe, Americas, Australia). A total of 7092 responses were obtained (n=5090 pregnant women; n=2002 women with a child younger than 25 weeks). Descriptive statistics and logistic regression analysis were used.ResultsOf the respondents who stated that they needed information, 16.16% (655/4054) used one information source and 83.69% (3393/4054) used multiple information sources. Of respondents who used more than one information source, 22.62% (759/3355) stated that the information was conflicted. According to multivariate logistic regression analysis, factors significantly associated with experiencing conflict in medicine information included being a mother (OR 1.32, 95% CI 1.11-1.58), having university (OR 1.33, 95% CI 1.09-1.63) or other education (OR 1.49, 95% CI 1.09-2.03), residing in Eastern Europe (OR 1.52, 95% CI 1.22-1.89) or Australia (OR 2.28, 95% CI 1.42-3.67), use of 3 (OR 1.29, 95% CI 1.04-1.60) or >4 information sources (OR 1.82, 95% CI 1.49-2.23), and having ≥2 chronic diseases (OR 1.49, 95% CI 1.18-1.89). Because of conflicting information, 43.61% (331/759) decided not to use medication during pregnancy, 30.30% (230/759) sought a new information source, 32.67% (248/759) chose to rely on one source and ignore the conflicting one, 25.03% (190/759) became anxious, and 2.64% (20/759) did nothing. Factors significantly associated with not using medication as a consequence of conflicting information were being pregnant (OR 1.75, 95% CI 1.28-2.41) or experiencing 3-4 health disorders (OR 1.99, 95% CI 1.10-3.58). Women with no chronic diseases were more likely not to take medicines than women with ≥2 chronic diseases (OR 2.22, 95% CI 1.47-3.45). Factors significantly associated with becoming anxious were >4 information sources (OR 2.67, 95% CI 1.70-4.18) and residing in Eastern Europe (OR 0.57, 95% CI 0.36-0.90).ConclusionsAlmost all the pregnant women used multiple information sources when seeking information on taking medicines during pregnancy and one-fifth obtained conflicting information, leading to anxiety and the decision not to use the medication. Regional, educational, and chronic disease characteristics were associated with experiencing conflicting information and influenced the decision not to use medication or increased anxiety. Accurate and uniform teratology information should be made more available ...

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Section: Discussionmentioning

confidence: 99%

Multiple Information Sources and Consequences of Conflicting Information About Medicine Use During Pregnancy: A Multinational Internet-Based Survey

Hämeen‐Anttila¹,

Nordeng²,

Kokki³

et al. 2014

J Med Internet Res

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show abstract

“…Most studies were general in nature with no limits on the type of enquiry included, however three studies restricted the sample to a specific type of enquiry; Stubbington evaluated adverse effect questions (Stubbington et al., ), whilst Frost Widnes included only questions about pregnancy (Frost Widnes & Schjøtt, ) and Strobach selected drug–drug interaction questions (Strobach et al., ). Studies ranged in duration from 2 weeks (Bramley, Mohandas, Soor, Erskine & Oborne, ) to the longest studies being 18 and 24 months, respectively (Maywald et al., ; Schjøtt et al., ).…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies attempted to determine clinician opinion about the impact MI advice on patient care (Bertsche et al., ; Bramley et al., , ; Cardoni & Thompson, ; Innes, Bramley & Wills, ; Melnyk et al., ; Stubbington et al., ), although two studies were primarily user satisfaction surveys with supplementary question(s) about impact/patient outcomes (Bertsche et al., ; Frost Widnes & Schjøtt, ).…”

Section: Resultsmentioning

confidence: 99%

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Impact of pharmacy medicine information service advice on clinician and patient outcomes: an overview

Rutter

2019

Health Info Libraries J

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Background Pharmacy‐led medicine information (MI) services are available in many countries to support clinicians and patients make decisions on use of medicines. Objectives To establish what impact, if any, pharmacy‐led MI services have on clinician and patient outcomes. Methods All published works indexed in Embase or PubMed, meeting this review's inclusion and exclusion criteria, that wholly or partially attempted to measure the effects of MI advice were retrieved and assessed. Results Twenty studies were reviewed. Five broad themes were identified describing study findings, three were specific to clinicians: their views on the effect MI answers had; actions they took; and influence on their decision making. A fourth theme centred on patient utilisation of advice, and the fifth on ‘process measures’ attempting to determine MI worth. Discussion Studies report on positive patient outcomes as a direct result of MI advice. Clinicians and patients acted upon the advice provided. Clinicians also reported using MI advice as a ‘safety net’, to check, reassure or confirm what to do. MI advice also demonstrated economic worth, although these studies are old. Conclusion MI Service advice appears to affect clinician and patient outcomes. However, study design limitations require findings be viewed cautiously.

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“…These studies cover the period of 1995–1998 and 2006. Interestingly, the study from 2006 concerned drug information in pregnancy, which represents a category of questions where re-use of information in the database is particularly frequent 3. However, such evaluations are performed by a selected group of physicians and cannot be generalised to other healthcare professionals.…”

Section: Discussionmentioning

confidence: 99%

A question–answer pair (QAP) database integrated with websites to answer complex questions submitted to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive study

et al. 2012

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ObjectiveTo assess a question–answer pair (QAP) database integrated with websites developed for drug information centres to answer complex questions effectively.DesignDescriptive study with comparison of two subsequent 6-year periods (1995–2000 and 2001–2006).SettingThe Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS).ParticipantsA randomised sample of QAPs from the RELIS database.Primary outcome measureAnswer time in days compared with Mann–Whitney U test.Secondary outcome measureNumber of drugs involved (one, two, three or more), complexity (judgemental and/or patient-related or not) and literature search (none, simple or advanced) compared with χ2 tests.Results842 QAPs (312 from 1995 to 2000 and 530 from 2001 to 2006) were compared. The fraction of judgemental and patient-related questions increased (66%–75% and 54%–72%, respectively, p<0.01). Number of drugs and literature search (>50% advanced) was similar in the two periods, but the fraction of answers referring to the RELIS database increased (13%–31%, p<0.01). Median answer time was reduced from 2 days to 1 (p<0.01), although the fraction of complex questions increased from the first to the second period. Furthermore, the mean number of questions per employee per year increased from 66 to 89 from the first to the second period.ConclusionsThe authors conclude that RELIS has a potential to efficiently answer complex questions. The model is of relevance for organisation of drug information centres.

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Drug use in pregnancy—physicians’ evaluation of quality and clinical impact of drug information centres

Cited by 19 publications

References 22 publications

Multiple Information Sources and Consequences of Conflicting Information About Medicine Use During Pregnancy: A Multinational Internet-Based Survey

Multiple Information Sources and Consequences of Conflicting Information About Medicine Use During Pregnancy: A Multinational Internet-Based Survey

Impact of pharmacy medicine information service advice on clinician and patient outcomes: an overview

A question–answer pair (QAP) database integrated with websites to answer complex questions submitted to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive study

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