2018
DOI: 10.1186/s12936-018-2332-3
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Drug use in the management of uncomplicated malaria in public health facilities in the Democratic Republic of the Congo

Abstract: BackgroundMalaria the first causes of death from parasitic infection worldwide. Interventions to reduce the burden of malaria have produced a tremendous drop in malaria morbidity and mortality. However, progress is slower in DRC, which shares with Nigeria 39% of deaths related to malaria globally. Inappropriate use of drugs may be one of the factors of this below-average performance. The aim of this study was to describe the use of drugs in the management of uncomplicated malaria in public health facilities in… Show more

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Cited by 23 publications
(20 citation statements)
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“…The discrepant results between CHIKV ELISA and IIFT were at least partly explained by the cross-reaction with actual malaria infection, a phenomenon which has been described before for ZIKV (42). Furthermore, we were able to document the common practice of overprescription of antimalarial drugs in malaria RDT-negative patients, as is apparently the case nationwide in DRC as recently shown by Ntamabyaliro et al (43). Indeed, while not even half of the patients tested positive for malaria, almost 90% received antimalarial treatment, in addition to 16% of patients treated with over-the-counter antimalarials prior to presentation at the clinic, which brings the total close to 100%.…”
Section: Resultssupporting
confidence: 78%
“…The discrepant results between CHIKV ELISA and IIFT were at least partly explained by the cross-reaction with actual malaria infection, a phenomenon which has been described before for ZIKV (42). Furthermore, we were able to document the common practice of overprescription of antimalarial drugs in malaria RDT-negative patients, as is apparently the case nationwide in DRC as recently shown by Ntamabyaliro et al (43). Indeed, while not even half of the patients tested positive for malaria, almost 90% received antimalarial treatment, in addition to 16% of patients treated with over-the-counter antimalarials prior to presentation at the clinic, which brings the total close to 100%.…”
Section: Resultssupporting
confidence: 78%
“…Furthermore, we were able to document the common practice of over-prescription of antimicrobials, including antimalarial drugs, in malaria RDT-negative patients, as is apparently the case nationwide in DRC as recently shown by Ntamabyaliro et al [55]. Indeed, while not even half of the patients (45.3%) tested positive for malaria–a figure just below average national RDT positivity rates [30], close to 90% received antimalarial treatment, in addition to 15.5% of patients treated with over-the-counter antimalarials prior to presentation at the clinic.…”
Section: Discussionsupporting
confidence: 57%
“…In addition, the economic impact is likely a conservative estimate, as a high proportion of children in the DRC receive concomitant prescriptions with antimalarials, which was not accounted for in our model. 46 Fourth, our disease model is based on symptomatic recovery rather than parasite clearance, which may affect transmission patterns and overall health outcomes. 47 We were also not able to estimate the impact of treatment adherence, as there was little recent data available.…”
Section: Discussionmentioning
confidence: 99%