Drug Utilization Evaluation of Anti-Diabetic Medication through Prescription Monitoring

Abstract

Diabetes is a chronic and potentially disabling disease that represents an important public health and clinical concern. The study was designed to assess the drug utilization evaluation of anti-diabetic medications through prescription monitoring in a tertiary care hospital at capital city Dehradun in a northern state Uttarakhand. Prescriptions from patients of diabetes were selected for the study and data was collected from patients using a questionnaire format. All the necessary and relevant information will be collected from out-patient prescriptions, laboratory data reports and also by verbal communication with patients. Out of total 100 prescriptions of diabetic patients, it was found that gender wise distribution of diabetic patients was more in females (64%) as compared to males (36%). Among 100 patients, type 1 diabetes occurred in 16% patients and type 2 diabetes occurred in 84% patients. It was also analyzed that both type 1 and type 2 diabetes were mostly occurred in females. Among type 2 diabetes patients, Glimepiride were mostly prescribed in 42% patients, followed by Metformin in 22% patients and Gliclazide in 20% while in type 1 diabetes patients, Human Insulin were prescribed in 16% patients. Prescription analysis showed that maximum prescriptions (50%) contain two drugs per prescription while six drugs per prescription were shown by only 2% prescriptions. This study may provide further help to prescribers for improvement in current prescribing trends in the management of diabetes mellitus.
 

Drug Utilization Evaluation of Anti-diabetics in Type 2 Diabetes Mellitus Patients with or without Comorbidities in a Tertiary Care Teaching Hospital

“…In our study, we observed more patients who are either obese or overweight. The study also revealed that hypertension (38%) was the most predominant comorbidity followed by cardiovascular disease (23%), which is comparable with a similar previous study conducted in Uttarakhand by Yogesh J et al 2 with regard to the comorbidity in patients with diabetes. The association between diabetes and hypertension is clinically important because it amplifies the risk of diabetic complications.…”

“…Beneficial effects of metformin include delayed progression of the disease, improve lipid profile, weight reduction, cost and low incidence of adverse effects, reduce insulin resistance thus slightly less incidence of hypoglycemia, prevents microvascular and macrovascular complication and can be associated with any other anti-diabetic agent. [1][2][3] Among fixed drug combinations, our study found that the combination of metformin and glimepiride was the commonly prescribed regimen (34 patients). This finding is in line with that of studies conducted in Karnataka by Jagadeesh K et al 5 It is noticeable that glimepiride remains the best choice for combination with metformin due to its maximum potency to lower blood glucose level.…”

“…1 The escalation in the incidence of diabetes purses the trend of urbanization and changing lifestyle includes less physical activitiesand intake of energy-dense foods with poor nutritional value. 2 As per World Health Organization (WHO), In the year 2000, there were around 31.7 cases of DM and it is thought to reach around 80 million by the year 2030. 3,4 Type 2 DM can also have comorbid conditions like hypertension (HTN), dyslipidemia and chronic kidney disease (CKD).…”

Prescribing Patterns of Antidiabetic in Patients with Type 2 Diabetes Mellitus at Levy and Chilenje Hospitals in Zambia

“…These results agree with WHO country profile on Zambia that indicated that there was a higher percentage of women with diabetes type 2 compared to men [11]. Similarly, [12], reported that there were more female (64%) than male (36%) patient prescriptions in a study conducted at Shri Mahant Indiresh Hospital in India.…”