Drug Utilization Pattern and Cost Analysis in Rheumatoid Arthritis Patients – A Cross–Sectional Study in Tertiary Care Hospital, Mumbai

Gawde, S.

doi:10.9734/bjpr/2013/2229

Cited by 14 publications

(5 citation statements)

References 7 publications

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“…9,17 In the study by Gurung S et al the most commonly prescribed drug following DMARDs was Analgesics 28.71%, the similar finding has been found in the present study the prescribed analgesics were 18.80%. 13 In our study the most commonly prescribed antacids were pantoprazole 50.20%, which is similar to other study where 41.17% pantoprazole were prescribed.…”

Section: Discussionsupporting

confidence: 89%

Prescribing pattern in Rheumatoid Arthritis patients in a tertiary care teaching hospital

Dutta¹,

Beg²,

Bawa³

et al. 2017

Int J Basic Clin Pharmacol

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INTRODUCTIONPrescription writing can be depicted as an art, since it reflects the directions given by the prescriber to the patients or their representatives.1 Therefore, a prescription written by a physician is a reflection of his perspective towards the particular disease and the role of drug in its treatment. It also provides an apprehension into the essence of the health care delivery system. Examining and monitoring of prescriptions and drug utilization studies can actually analyze the recent trend of prescription pattern which will further help to identify the problems and provide feedback to prescribers. Defining drug prescription and utilization pattern provides advantageous feedback to prescribers in order to improve their prescribing behaviour. 2 ABSTRACTBackground: Rheumatoid arthritis (RA) is associated with joint deformity and significant health care related expenses. This disease affects approximately 1% of the adult population, the prevalence of RA in India is approximately 0.75% and increasing trend has been observed. Irrational prescribing is a common phenomenon around the globe. The drug utilization studies form an important tool for the assessment of rational or irrational prescribing and WHO drug use indicators. Thus keeping this in view the prescribing pattern analysis in RA patients was done. Methods: This prospective study was carried out by the department of pharmacology in medicine OPD of SGRRIM and HS, Dehradun for one year. A total of 450 RA diagnosed patients were included in the study. The diagnosis was made on the basis of clinical assessment and lab parameters as rheumatoid factor and anti-ccp. The collected prescriptions were analyzed by using WHO drug use indicators. Results: Total of 450 prescriptions was analyzed. 378 (84%) were females and 72 (16%) were males. Most commonly presenting age group was 31-60 years 276 (61.33%). Family history and RA factor was positive in 168 (37.33%) and 318 (70.67%) patients respectively. Anti-ccp was raised in 408 (90.67%) patients. The comorbid conditions were type-2 diabetes mellitus 72 (16%), hypertension 48 (10.67%), hypothyroidism 36 (8%) and other associated illness 54 (12%). Total of 1655 drugs were prescribed during the study period. The prescribed drugs were disease modifying anti-rheumatic drugs (DMARDs) 582 (35.18%), vitamin-D3 and calcium supplements 320 (19.34%), analgesics 311 (18.80%), antacids 204 (12.33%), others 238(14.38%). 437 (26.40%) fixed dose combinations (FDCs), 3.67 drugs per prescription, 1145 (69.18%) drugs by brand names and 1161 (70.15%) drugs from the National List of Essential Medicine (NLEM) 2015 were prescribed. Conclusions: Drug prescribing pattern depicts that most commonly prescribed were DMARDs, vitamin-D3 and calcium supplements and analgesics. Most of the drugs were prescribed from NLEM 2015.

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Section: Discussionsupporting

confidence: 89%

Prescribing pattern in Rheumatoid Arthritis patients in a tertiary care teaching hospital

Dutta¹,

Beg²,

Bawa³

et al. 2017

Int J Basic Clin Pharmacol

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“…[21,28] The mean age of Rheumatoid Arthritis patients in the present study is 45.85 ± 9.54 years with the mean (± SD) age of onset of Rheumatoid Arthritis in patients is 41.48 ± 9.38 years. This finding is in accordance with the Indian scenario of mean age of RA 43±4, 47.2 years [26,29] and mean age of onset of RA 43±4 years and 40.57±13.69 years [29,30] The incidence of RA increases between 25 and 55 years of age, after which it plateaus until the age of 75 and then decreases ] which is approximately same with the Indian scenario. [31] .…”

Section: Discussionsupporting

confidence: 86%

Quality of Life in Rheumatoid Arthritis patients taking combination DMARDs

Singh¹

2017

jmscr

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“…[ 19 ] In contrast to our study where the majority (73.3%) received MTX monotherapy, most other studies have reported two DMARD combination as the most frequently used regimen to manage RA. [ 20 ] Only one study with similar use of methotrexate monotherapy was found which reported majority patients on single DMARD therapy. [ 21 ] Various other studies have reported combinations of three conventional synthetic DMARDs as the most commonly used regimen.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of prescription practices in rheumatoid arthritis at the rheumatology clinic in a tertiary care teaching hospital in Uttarakhand

Mittal

Bisht

Pai

et al. 2021

Journal of Family Medicine and Primary Care

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Objective: This study was aimed to analyze the prescription pattern of disease modifying anti-rheumatic drug (DMARD) therapy in patients with rheumatoid arthritis (RA) in a tertiary care teaching hospital in Uttarakhand, India. Methodology: This cross-sectional study was conducted in 150 RA patients who were given DMARD therapy. Patient's demographic details, drugs prescribed with their dosage and administration routes and the usage of complementary and alternative medicine (CAM) therapy were recorded to study the prescription pattern. Results: Overall, 4 DMARDs were prescribed in all the studied patients: Methotrexate ( n = 150), hydroxychloroquine ( n = 35), leflunomide ( n = 5), and adalimumab ( n = 1). Single DMARD therapy with methotrexate was prescribed to 110 (73.3%) followed by double therapy with methotrexate + hydroxychloroquine in 35 (23.3%), triple therapy (methotrexate + hydroxychloroquine + leflunomide) in 4 (2.7%) and triple therapy with biological DMARD (methotrexate + hydroxychloroquine + leflunomide + adalimumab) in 1 (0.7%) patient. Adjuvant therapy drugs included: Prednisolone ( n = 150), folic acid ( n = 150), naproxen ( n = 150), calcium ( n = 150), vitamin D ( n = 150) and indomethacin ( n = 40). Of the total, 61.4% patients also took complimentary alternative medicine (CAM) therapy. Conclusion: Our study concludes that the most commonly prescribed DMARDs in our setting, to patients of RA, in descending order of frequency were methotrexate, followed by hydroxychloroquine, leflunomide and lastly adalimumab. A total of five adjuvant medications were commonly prescribed to all patients. There was a high prevalence of self-medicated CAM therapy in the majority of these patients.

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Drug Utilization Pattern and Cost Analysis in Rheumatoid Arthritis Patients – A Cross–Sectional Study in Tertiary Care Hospital, Mumbai

Cited by 14 publications

References 7 publications

Prescribing pattern in Rheumatoid Arthritis patients in a tertiary care teaching hospital

Prescribing pattern in Rheumatoid Arthritis patients in a tertiary care teaching hospital

Quality of Life in Rheumatoid Arthritis patients taking combination DMARDs

Evaluation of prescription practices in rheumatoid arthritis at the rheumatology clinic in a tertiary care teaching hospital in Uttarakhand

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