Drug utilization pattern and physician adherence to treatment guidelines in inpatients with urinary tract infection

Sharma, Abhishek; Oommen, Shweta

doi:10.18203/2319-2003.ijbcp20180646

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Study result showed that UTIs was more common in female which is consistent with two other studies perfomed on patients suffering from UTI (Ahmed, JAKRIBETTU, KOYAKUTTY, Arya, & Shakir, 2012; Gidamudi et al, 2015).Most Commonly prescribed drugs for treatment of UTI were antibiotics such as fluoroquinolones and cephalosporins this findings is accordance with other similar studies (Gidamudi et al, 2015;Sharma & Oommen, 2018). As the results of the study Pargavi B. et al,19% study also shows E. coli was the most commonly isolated organism in urine culture.…”

Section: Discussionsupporting

confidence: 90%

Utilization Review of Antibiotics in the Treatment of Urinary Tract Infection

Zafar¹,

Arshad²,

Hassn³

et al. 2022

PJMHS

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Aim: To evaluate the rationality of pharmacotherapy of UTI and to identify drug related problems (DRPs) in the treatment of UTI. Methodology:, a prospective study was perfomed in Ayub Teaching Hospital Abbottabad Pakistan for a period of three months (December 2019 to March 2020) on 62 patients suffering from UTI. Data of patient disease and treatment was collected from patient medical chart record file and then pharmacotherapy was evaluated for accessing rationality and identification of DRP using standard book like British national formulary and standard treatment guidelines. Statistical analysis of the data was performed by using SPSS.Results: Result of this study showed that prevalence of UTI was more in female (67.74%) than males (32.25%). Patients belonging to the age group of 20-40 years were more prone to UTI. The most frequent problems were presence of drug interactions, dosage problems cases, overprescribing cases, therapeutic duplication cases and lack of cost effectiveness cases. After analyzing the use of antibiotics it was found that most widely used antibiotics in the treatment of UTI was ceftriaxone, followed by levofloxacin and ciprofloxacin. Culture Sensitivity test for appropriate selection of antibiotics was not perfomed in 80% of cases. Wrong dose of antibiotics was prescribed in 27.4% cases; therapeutic duplication of antibiotics was found in 6% of patient prescription and over usage of antibiotics was observed in 18% of cases. Conclusion: Irrational use of drugs especially antibiotics in the treatment of UTI can adversely affect desired therapeutic outcome, lead to therapy failure and emergence of resistance of antibiotics which is a major concern. Drugs for the treatment of UTI should be used rationally according to the need and standard prescribing protocol to improve patient therapeutic outcome and to decrease the adverse consequences of drug therapy. .

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Section: Discussionsupporting

confidence: 90%

Utilization Review of Antibiotics in the Treatment of Urinary Tract Infection

Zafar¹,

Arshad²,

Hassn³

et al. 2022

PJMHS

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“…37 However a recent retrospective, record-based study recorded a contradictory finding with 98.1% drugs prescribed in generic form in a tertiary care hospital in inpatients with urinary tract infection. 38 Prescribing by generic name needs to be promoted in our hospital to curb drug duplication, medication error and adverse effects due to medication therapy. Almost two-third of patients showed good adherence with the prescribed treatment.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Use Evaluation in Genitourinary Tract Infections in Female Patients at a Tertiary Care Hospital

Alam¹,

Sharma²,

Dubey³

et al. 2020

jemds

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A B S T R A C T BACKGROUNDGenitourinary tract infections are some of the most common infections in females. These problems are a challenge in terms of diagnosis and treatment. The present study was conducted to evaluate the prescribing pattern in three of the most common types of female genitourinary tract infections. METHODSA prospective and observational study was conducted on genitourinary tract infections in female patients at the gynaecology outpatient department in a tertiary care university hospital. RESULTSMajority of the infected female patients were in 26 -35 years age group (31.8%) followed by 36 -45 years age group (25.9%). The common infection noticed was urinary tract infection (42.2%), followed by pelvic inflammatory disease (32.2%) and vaginitis (25.5%) in infected female patients. The types of antibiotics prescribed for urinary tract infection were aminoglycosides, fluoroquinolones, cephalosporins and penicillins. The commonly prescribed antibiotics for pelvic inflammatory disease were tetracyclines, azoles, fluoroquinolones and cephalosporins, and for vaginitis azoles and aminoglycosides. The most commonly prescribed class of antibiotics for urinary tract infection, pelvic inflammatory disease and vaginitis were fluoroquinolones (11.8%), azoles (11.8%) and aminoglycosides (15.7%), respectively. Oral route was the preferred mode of administration (71%), followed by rectal (suppositories, 17.2%) and topical (cream, 11.8%). CONCLUSIONSYoung married women in this urban Indian community have a high prevalence of genitourinary tract infections but seldom seek treatment. Education and outreach are needed to reduce the stigma, embarrassment and lack of knowledge related to genitourinary tract infections.

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“…Gidamudi et al and Sharma et al 2018. 7,8 Over the years procurement of Access group antibiotics declined by 20% and there was an increase watch group consumption. WHO goal is to target that 60% of all antibiotic's procurement should be from access group,9 but unfortunately in our study, that trend is going in opposite direction.…”

Section: Discussionmentioning

confidence: 99%

Trend analysis of antibiotics consumption using WHO AWaRe classification in tertiary care hospital

Bhardwaj¹,

Kapoor

Singh

2020

Int J Basic Clin Pharmacol

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Background: Aim of the study was to assess trend in antibiotics consumption pattern from 2016 to 2019 using AWaRe classification, ATC and Defined daily dose methodology (DDD) in a tertiary care hospital. Antibiotics are crucial for treating infectious diseases and have significantly improved the prognosis of patients with infectious diseases, reducing morbidity and mortality. The aim of the study is to classify the antibiotic based on WHO AWaRe classification and compare their four-year consumption trends. The study was conducted at a tertiary care center, Pilakhuwa, Hapur. Antibiotic procurement data for a period of 4 years (2016-2019) was collected from the Central medical store.Methods: This is a retrospective time series analysis of systemic antibiotics with no intervention at patient level. Antibiotic procurement was taken as proxy for consumption assuming that same has been used. ATC for systemic use (ATC code J01) antibacterial was used and defined daily dose (DDD) per 100 bed days was calculated. Antibiotics were further classified as Access, Watch, and Reserve (WHO AWaRe classification). Antibiotics consumption was ranked based on their volume of DDD i.e., drug utilization (DU90%) was calculated. Non-parametric Pearson’s correlation coefficient was used for the comparison of consumption.Results: Mean antibiotic procurement increased 1.25 folds from 140.3 DDD in 2016 to 201 DDD in 2018. A significant fall was seen in total DDDs in year 2019 (p value <0.05). A total of 41 antibiotics agents (Access 12, Watch 21, Reserve 6 and Not recommended 2) were procured. Reserve category antibiotics were procured from 2017 onwards. Out of 41 antibiotics procured 11 antibiotics (Access 3 and watch 8) accounted for DU 90%.Conclusions: Antibiotics consumption of watch group was high and increasing antibiotic consumption trend was observed. Hospital antimicrobial stewardship program should be implemented to shift to use of Access group antibiotics and restrict use of Watch antibiotics.

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Drug utilization pattern and physician adherence to treatment guidelines in inpatients with urinary tract infection

Cited by 3 publications

References 14 publications

Utilization Review of Antibiotics in the Treatment of Urinary Tract Infection

Utilization Review of Antibiotics in the Treatment of Urinary Tract Infection

Antibiotic Use Evaluation in Genitourinary Tract Infections in Female Patients at a Tertiary Care Hospital

Trend analysis of antibiotics consumption using WHO AWaRe classification in tertiary care hospital

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