Drug utilization pattern of antidiabetic agents in a tertiary care hospital of western Odisha, India

Agrawal, Ratna; Rath, Bhabagrahi; Saha, Kaustav; Mohapatra, Sabita

doi:10.18203/2319-2003.ijbcp20163265

Cited by 7 publications

(8 citation statements)

References 6 publications

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“…In present study out of 282 Diabetic Patients, 16(5.67%) was suffering from Type I DM while 266 (94.32%) was suffering Type II DM which is almost similar to a study done by Agrawal R et al, who reported 96.52% 0f patients with Type II DM while 3.48% with Type I DM out of 230 Patients. 40…”

Section: Discussionmentioning

confidence: 99%

A prospective study on drug utilization pattern of anti-diabetic drugs in a tertiary care teaching hospital of eastern Uttar Pradesh, India

pankaj¹,

Satendra²,

Dhananjay³

et al. 2019

Int J Res Med Sci

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Background: Diabetes mellitus is a metabolic disorder with common denominator of hyperglycemia, arising from a variety of pathogenic mechanisms. The aim of the study was to evaluate the drug utilization pattern of anti-diabetic drugs in diabetic patients and observe adverse drug events (ADEs) associated with anti-diabetic therapy in a prospective way.Methods: A prospective study was carried out in diabetic patients visiting the Departments of General Medicine in a tertiary care teaching hospital. Demographic data, drug utilization pattern and ADEs due to Anti-diabetic drugs were summarized.Results: In the present study, 153 (54%) of the 282 diabetic patients were males and 129 (46%) were females. Majority of patients were in the age group of 51-60 years (31.20%) and most of the patients (31.56%) had a diabetic history of 11-15 years. Metformin was the most commonly prescribed drug (64.89%). Majority of the patients (36.87%) were on multidrug therapy. Co-morbid condition was found in 232 patients (82.26%) where hypertension (22.69%) being the most common co-morbid condition. 32 ADRs were observed with Nausea being the most common ADR reported.Conclusions: The present study helps to find out current prescribing pattern of oral diabetic medications with different co-morbidities with respect to diagnosis, cost of treatment and it also highlight the need for comprehensive management of diabetic patients, including life style changes, dietary control, hypoglycemic agents, cardiovascular prevention, treatment of complications and co-morbidity. Therefore, through the existing prescribing patterns, attempts can be made to improve the quality and efficiency of drug therapy.

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Section: Discussionmentioning

confidence: 99%

A prospective study on drug utilization pattern of anti-diabetic drugs in a tertiary care teaching hospital of eastern Uttar Pradesh, India

pankaj¹,

Satendra²,

Dhananjay³

et al. 2019

Int J Res Med Sci

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“…Similar findings were seen in other studies. 4,11,12 Among sulfonylureas, Glibenclamide was most commonly used 17.9%. Voglibose an α-glucosidase inhibitor in combination with other oral antidiabetic drugs was prescribed in 64.1% patients.…”

Section: Discussionmentioning

confidence: 99%

Drug utilization study and adverse drug reactions of oral anti diabetics among type 2 diabetes mellitus patients in tertiary care hospital

Mogali¹,

Bhushan²,

Ratnakar³

2019

Int J Basic Clin Pharmacol

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Background: The aim was to evaluate the drug utilization pattern of oral antidiabetic drugs in type 2 diabetes mellitus outpatients and monitor adverse drug reactions (ADRs) associated with oral antidiabetic drugs.Methods: A retrospective observational study was carried out by collecting the data of type 2 diabetes mellitus patients visiting outpatient department of noncommunicable disease clinic of a tertiary care hospital for a period of one year. The data of demographic, drug utilization pattern and adverse drug reactions of patients on oral antidiabetic drugs was collected and entered in a proforma.Results: Total number of patients in this study were 39 out of which 21 (53.85%) patients were females and 18 (46.15%) patients were males. Majority of patients were in the age group 51-70 years (66.6%). Metformin was the most commonly prescribed drug 76.9% followed by Glibenclamide 17.9%. About 7.7% of patients who were taking oral antidiabetic drugs later switched over to insulin as their blood glucose levels were not controlled. Out of 18 (46.15%) patients, hypertension (38.5%) was the most common comorbid condition and a concomitant drug was prescribed was amlodipine 25.6%. Among all the adverse drug reactions observed, diarrhoea was the most common adverse drug reaction reported 76.9%.Conclusions: Metformin was the most commonly used oral antidiabetic drug. Diarrhoea was the common adverse drug reaction reported.

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“…3,13 However, Agrawal et al reported male: female ratio of 3:1 which is way higher. 12 Most probable reason for male preponderance might be the fact that women's health is still neglected in most parts of the country and therefore, it is less likely that a women will visit healthcare facility under such circumstances. The average number of drugs per prescription in the present study was less than that found in other studies, wherein average number of drugs per prescription was reported around 4.…”

Section: Discussionmentioning

confidence: 99%

“…DDD (defined daily dose) per 1000 inhabitants per day is usually employed to obtain a fair projection of prevalence of drug use in a particular set of population or prevalence of chronic disease where drug is being used for a specific indication [15]. It was calculated by the formula: 12…”

Section: Methodsmentioning

confidence: 99%

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2019

MIJOPHAR

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Background: Diabetes mellitus (DM) is defined as chronic diseases characterized by derangements in metabolism of carbohydrates, protein and fat. As per WHO, drug utilization (DU) is defined as marketing, distribution, prescription, and use of drugs in society, with special emphasis on emerging medical, social and economic consequences. Aims and objectives: To analyze the drug utilization pattern of oral hypoglycemic drugs in rural area of Jalgaon district, India using WHO drug utilization indicators, and to analyze drugs prescribed per prescription. Materials and Methods: The present study was case control, record based, observational study carried out at Medical Record Section, Dr. Ulhas Patil Medical College and Godavari hospital, Jalgaon, Maharashtra, India. Results: Out of 250 patients data analyzed, majority of the patients were in the age group 51-60 (60 patients). Maximum number of patients had DM since 5 to 10 years (75 patients). Monotherapy with OHD was given in 8 patients (3.2%), dual OHDs therapy in 150 (60%) patients, triple therapy in 31 patients (12.4%), quadruple OHDs in 4 patients (1.6%) and insulin + OHD/s therapy in 57 patients (22.8%). DDD/1000 inhabitants/day was more than DDD in case of metformin, glimepiride, sitagliptin, voglibose, and insulin. DDD/1000 inhabitants/day was less than DDD in case of glipizide, glibenclamide, pioglitazone. Conclusion: There is need to increase awareness about the use of generic drugs on a mass scale in pursuit of making optimal diabetes care available at comparatively low cost, without affecting their efficacy.

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Drug utilization pattern of antidiabetic agents in a tertiary care hospital of western Odisha, India

Cited by 7 publications

References 6 publications

A prospective study on drug utilization pattern of anti-diabetic drugs in a tertiary care teaching hospital of eastern Uttar Pradesh, India

A prospective study on drug utilization pattern of anti-diabetic drugs in a tertiary care teaching hospital of eastern Uttar Pradesh, India

Drug utilization study and adverse drug reactions of oral anti diabetics among type 2 diabetes mellitus patients in tertiary care hospital

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