Drug Utilization Study In Primary Glaucoma Patients Attending the Ophthalmology Outpatient Department of a Tertiary Care Hospital in Western Uttar Pradesh

Parween, Nazia

doi:10.7869/djo.286

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…[10] Our study show 48.57% patients received monotherapy which is quite similar to study by Rai S et al in which monotherapy was prescribed to 48 patients (64.86%) [11] & out of 184 drugs, total no of 130 drugs were prescribed in monotherapy & most frequently prescribed group of drugs came out to be carbonic anhydrase inhibitors (29.89%) which is different from the study by Nazia P et al which analysed out of 116 glaucoma patients, amongst the medications, beta blockers were prescribed the most (38.12%), followed by carbonic anhydrase inhibitors (both oral and topical) and prostaglandin F2α analogues (14.36% each). The less commonly prescribed medicines were α2 agonists, cholinergic drugs, glycerol and antimicrobials [12] .…”

Section: Discussionmentioning

confidence: 99%

Drug Utilization and Prescribing Pattern of Glaucoma in a Tertiary Care Hospital of Dehradun

Mamgain¹,

Jauhari

2019

J. Drug Delivery Ther.

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Glaucoma is a condition in which distinctive changes occur in the optic nerve and visual field. In glaucoma intraocular pressure (IOP) is raised that compresses and damages the optic nerve. As the optic nerve is damaged, it fails to carry the visual information to the brain which induce clinically progressive loss of peripheral visual field and ultimately loss of vision. AIMS AND OBJECTIVES: To Evaluate the drug utilization and prescribing pattern of drugs used for treatment of glaucoma, to analyze current prescribing trends in anti-glaucoma drugs, to perform a drug utilization study, to identify drugs per prescription, category wise identification of drugs prescribed, mono therapy vs combination therapy. MATERIALS AND METHODS: The present study was a prospective, observational study carried out in 105 patients at Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India. RESULTS: Out of total 105 patients, 68 were males (64.76%) and 37 were females (35.24%). The most common age group was 46-60 years. Patients were mostly affected by primary open angle glaucoma (95.23%) then angle closer glaucoma (4.76%). Total 184 drugs were prescribed in the treatment of glaucoma. Average number of drugs per prescription was 1.75. Combination therapy was prescribed in 51.43% patients & most common used combination therapy was combination of Brimonidine+ timolol (81.48%) followed by Bimatoprost+ timolol (18.52%). Monotherapy was used in 48.57% patients in which drug dorzolamide (22.31%) was prescribed mostly which is belongs to the category of carbonic anhydrase inhibitors followed by timolol (19.23%) (β- blockers) which was second line choice of drug. Generic drugs were mostly prescribed in 77 patients (73.33%) followed by 28 patients (26.66%) were brand names. CONCLUSION: The prescription analysis of glaucoma patients concluded that monotherapy with dorzolamide was the first line choice for glaucoma therapy and timolol was found to be the second line choice. Timolol+ brimonidine was the mostly prescribed combination of drug. It also showed that all drugs were prescribed in their generic name instead of brand name.

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Section: Discussionmentioning

confidence: 99%

Drug Utilization and Prescribing Pattern of Glaucoma in a Tertiary Care Hospital of Dehradun

Mamgain¹,

Jauhari

2019

J. Drug Delivery Ther.

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Cost Analysis and Rational Use of Anti-Glaucoma Therapy in a Tertiary Hospital in Ghana

Ofei-Palm¹,

Tagoe²,

Jatoe³

et al. 2021

CEOR

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Introduction Glaucoma is the leading cause of irreversible blindness worldwide. In Ghana, 19.4% of all blindness recorded is due to glaucoma. Reducing intraocular pressure medically (using eye drops) is the evidence-based therapeutic option. Objective To determine the rational use and undertake cost analysis of anti-glaucoma drugs among patients attending clinic at the Lions International Eye Centre (LIEC), Korle-Bu Teaching Hospital. Methods In this cross-sectional study, we reviewed all prescriptions presented to the pharmacy unit from 01/12/2015 to 31/03/2016. The dispensed drops were classified, and all anti-glaucoma drugs were identified. This was followed by cost analysis. Results A total of 588 prescriptions were captured, 27.3% (161/588) contained an anti-glaucoma medication. The mean number of anti-glaucoma medications was 1.71 of which 52.7% was prescribed to females. Prostaglandin analogs (PGA) were the most prescribed (37% (102/276)), followed by beta blockers (25.4% (70/276)), carbonic anhydrase group of medicines (16.3% (45/276)), combined beta blockers (11.2% (31/276)), alpha agonists (8.7% (24/276)) and miotics (1.4% (4/276)). The median (IQR) cost of anti-glaucoma therapy per prescription per month was GHC 65.00 (GHC38.5-GHC140) about [US$16.25 (US$ 9.6–US$35)]. Azopt (Brimonidine) was the most expensive with daily treatment cost of GHC 5.8 (about US$ 1.45), whilst the least expensive drug with a daily treatment cost of GHC 0.14 (about US$ 0.035) was timolol eye drops. Conclusion Prostaglandin analogs though expensive remain the most preferred treatment for managing glaucoma at the Korle-Bu Eye Centre in Ghana. This may adversely affect treatment among the poor since prostaglandins analogs are currently not covered by insurance.

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A Case Control Study on Risk Factors and Drug Prescription Patterns in Glaucoma at a tertiary eye care center in a city of Western India

Bharadwaj

Goswami

Shah³

et al. 2023

Healthline

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Introduction: Glaucoma is an idiopathic, progressive optic disc neuropathy complicating into irreversible blindness if untreated. Early diagnosis by screening cases from high-risk populations has a pivotal role in managing this major public health problem with high treatment expenditures. Objectives: To identify the various ocular and non ocular risk factors of glaucoma and to identify the drug prescription pattern among glaucoma patients. Method: This was an observational, case-control study including 165 adult Glaucoma patients on treatment as cases and 165 age and sex-matched healthy individuals as controls, all of which were randomly selected from the patients visiting a tertiary eye care center. Various risk factors, drug prescription pattern and symptoms of the patients were recorded and analyzed.Results: A total of 165 adult Glaucoma patients and age and gender matched 165 controls were enrolled. Majority of the patients (41.21%) complained of blurring of vision at the time of study. The Odds ratios for Family history, Hypertension, Diabetes Mellitus, Migraine, Sleep apnea and Smoking showed strong association as risk factors for Glaucoma and the differences between the two groups were statistically significant (p value < 0.05). The mean number of drugs per prescription ± SD was 1.88 ± 0.79. Fixed drug formulations were prescribed in 42.4% patients. All the drugs were prescribed by their brand names and majority of them were in the form of eye drops. Conclusion: Primary Open Angle Glaucoma (POAG) was the most common subtype in the study. Age, Family history, Myopia, Hypertension, Diabetes Mellitus, Sleep Apnea, Migraine, Corticosteroid usage and Smoking emerged as putative risk factors. In consistence with present guidelines, Prostaglandin analogs were the most prescribed antiglaucoma drugs. The considerable proportion of asymptomatic cases (23%) suggests the need for periodic eye examinations to detect glaucomatous changes at an early stage.

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Drug Utilization Study In Primary Glaucoma Patients Attending the Ophthalmology Outpatient Department of a Tertiary Care Hospital in Western Uttar Pradesh

Cited by 3 publications

References 14 publications

Drug Utilization and Prescribing Pattern of Glaucoma in a Tertiary Care Hospital of Dehradun

Drug Utilization and Prescribing Pattern of Glaucoma in a Tertiary Care Hospital of Dehradun

Cost Analysis and Rational Use of Anti-Glaucoma Therapy in a Tertiary Hospital in Ghana

A Case Control Study on Risk Factors and Drug Prescription Patterns in Glaucoma at a tertiary eye care center in a city of Western India

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