DrugDomain: the evolutionary context of drugs and small molecules bound to domains
Kirill E. Medvedev,
R. Dustin Schaeffer,
Nick V. Grishin
Abstract:Interactions between proteins and small organic compounds play a crucial role in regulating protein functions. These interactions can modulate various aspects of protein behavior, including enzymatic activity, signaling cascades, and structural stability. By binding to specific sites on proteins, small organic compounds can induce conformational changes, alter protein-protein interactions, or directly affect catalytic activity. Therefore, many drugs available on the market today are small molecules (72% of all… Show more
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