Druggable Vitiligo Genome: A Fast Track Approach to Take the Genome Wide Association to the Clinic

Narayanan, Ramaswamy

doi:10.15406/mojpb.2015.02.00050

Cited by 4 publications

(2 citation statements)

References 65 publications

(102 reference statements)

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“…The key disease proteins were analysed for their ability to be a good therapeutic target (Rask-Andersen et al, 2011). This was done under fi ve heads namely Druggability (Druggable Genome (Hopkins and Groom, 2002), can SAR druggability (Bulusu et al, 2014), DrugBank (Law et al, 2014), DGI druggability (Griffi th et al, 2013), PDTD (Gao et al, 2008) and Domain DrugEBIlity (EMBL) [https://www.ebi.ac.uk/chembl/drugebility/]) Assayability (Sigma Aldrich database, Brenda (Schomburg et al, 2017), Ki database [https://kidbdev.med.unc.edu/ databases/kidb.php], PDB (Berman et al, 2000) or Binding DB (Gilson et al, 2016)), Essentiality (OGE (Chen et al, 2012), MGD (Eppig et al, 2007), Human Phenotype project (Kohler et al, 2014), Part et al (Park et al, 2008) or Georgi et al (Georgi et al, 2013)), Vulnerability (Holme et al, 2002) and Secretability (Narayanan, 2015).…”

Section: Targetability Statistics For Disease Proteinsmentioning

confidence: 99%

Edifi ce of vitiDB: A fi rst ever structured portal for vitiligo protein repository and its assessment

Malhotra¹,

Singh²,

Jha³

et al. 2017

Biosci. Biotech. Res. Comm

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vitiDB (http://vitidb.com/index.php) is the fi rst ever structured repository exclusively for vitiligo disorder. This portal brings together valuable but heterogeneous or disparate information available from a spectrum of public domain databases, patents and published literature sources on vitiligo. The aim is to arm the research community with critical details extracted froma reviewed resource of vitiligo genes and proteins. In addition, the database throws light on interectome of proteins and their targetability assessment. The current release of vitiDB contains 333 vitiligo disease-associated proteins and nearly 5000 allied proteins. Each entry provides comprehensive data related to the protein like its kinetic, pharmacological and ontological properties. Additionally, this portal provides browsing and extracting information related to vitiligo protein interaction network and its topological properties. vitiDB catalogues 107416 unique interactions among 4845 proteins derived from 8 different databases. Detailed targetability analysis is available at this portaland it includes druggability, assayability, essentiality, vulnerability and secretability analysis for the disease proteins. This user-friendly web interface will help the user to have an informed opinion on disease genes without having to plough through various databases. The additional information in the form of derived data can potentially assist in the drug discovery process. There will be sustained effortsaimed at periodic updation of the core data in the wake of their extension / modifi cation as well as constructive feedback received from the users.

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Section: Targetability Statistics For Disease Proteinsmentioning

confidence: 99%

Edifi ce of vitiDB: A fi rst ever structured portal for vitiligo protein repository and its assessment

Malhotra¹,

Singh²,

Jha³

et al. 2017

Biosci. Biotech. Res. Comm

View full text Add to dashboard Cite

show abstract

“…Using such an approach, recently series of FDA approved drugs were predicted for possible repurposing in the treatment of Vitiligo, an autoimmune disease, 25 Ebola Virus disease 26,27 and the Zika virus infection. 28 The drug classes included antidiabetics, anti estrogens, antineoplastics, antithrombotics, antivirals, antihypertensives, statins as well as nutraceuticals.…”

mentioning

confidence: 99%