Drugs Acting on the Calcium Receptor

Nemeth, Edward F.

doi:10.1016/b978-0-12-373884-4.00084-7

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Manipulating the Calcium-sensing Receptor1

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2011

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“…High-throughput screening of low-molecular weight libraries in several pharmaceutical companies has so far resulted in only a few distinct calcilytic compound series. Several accounts of drugs acting on the CaSR have been written in recent years [29][30][31][32]. The purpose of this review is to give a comprehensive overview of the existing calcilytic classes, with the main focus being on novel compound classes that have been published more recently.…”

Section: Manipulating the Calcium-sensing Receptormentioning

confidence: 99%

Calcilytics: Antagonists of the Calcium-Sensing Receptor for the Treatment of Osteoporosis

Widler

2011

Future Med. Chem.

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The only bone anabolic agents currently available on the market are based on the parathyroid hormone (PTH). Secretion of endogenous PTH is controlled by a calcium-sensing receptor at the surface of the parathyroid glands. Antagonists of this receptor (calcilytics) induce the release of the hormone. Provided the effect of the calcilytic is of short duration, a bone anabolic effect should also result. Although the first calcilytic series became known approximately 10 years ago, the number of different structural types is still small today. This article outlines the quest from hits to potent development candidates of all relevant calcilytic series currently known. Even after the front-runners unexpectedly failed in the clinic, the approach for an oral alternative to parenteral PTH remains highly attractive.

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Section: Manipulating the Calcium-sensing Receptormentioning

confidence: 99%

Calcilytics: Antagonists of the Calcium-Sensing Receptor for the Treatment of Osteoporosis

Widler

2011

Future Med. Chem.

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show abstract

Drugs Acting on the Calcium Receptor

Cited by 1 publication

References 138 publications

Calcilytics: Antagonists of the Calcium-Sensing Receptor for the Treatment of Osteoporosis

Calcilytics: Antagonists of the Calcium-Sensing Receptor for the Treatment of Osteoporosis

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