Drugs and Recurrent Ocular Herpes

Involvement of CD8+T-cells in exacerbation of corneal scarring in mice

“…[1][2][3] Ocular infection with HSV-1 can cause eye disease ranging in severity from blepharitis, conjunctivitis, and dendritic keratitis to disciform stromal edema and necrotizing stromal keratitis. [4][5][6][7] HSV-1-induced corneal scarring can lead to blindness, making this virus the leading cause of corneal blindness due to an infectious agent in developed countries. 1,3,8 There are at least 11 antigenically distinct glycoproteins in HSV-1 virions, 9,10 among which is HSV-1 gK, which is encoded by the UL53 open reading frame (ORF).…”

Effects of topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity in ophthalmologically normal cats

“…Abundant evidence suggests that topical corticosteroids may exacerbate herpetic disease, and their use should be avoided in most cases of ocular surface disease in cats and other species. [2][3][4][5] When antiinflammatory treatment is necessary, topical NSAID ophthalmic solutions (topical NSAIDs) may be used preferentially over corticosteroids in patients with corneal ulceration, trauma, or infection. 6 Currently, there are no topical NSAIDs approved for use in veterinary patients; thus, topical NSAIDs approved for use in humans are used in an extralabel manner in vet-erinary practice.…”

Involvement of cellular death signals in the reactivation of herpes simplex virus type 1 and lambda bacteriophage from a latent state

“…It can be triggered by local stimuli, such as injury to tissues innervated by the neurons harboring latent infection (i.e. surgery on the trigeminal nerve root or branches), by systemic conditions: exposure to sun and ultraviolet (UV) light irradiation, fever, emotional stress and menstruation, or by various chemical agents (Haesaert, 1986) as shown in the Table 1. Clinically, lesions are closely clustered vesicles that usually reoccur at the same site, tend to remain localized and do not involve the entire dermatome.…”