Drugs Five Years Later: Desmopressin

Richardson, Donald W.; Robinson, Alan G.

doi:10.7326/0003-4819-103-2-228

Cited by 273 publications

(93 citation statements)

References 99 publications

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“…Desmopressin, 1-deamino-8-D-arginine-vasopressin, has considerably longer half-life than AVP but considerably less pressor activity [15]. Desmopressin is the first-line agent of choice for long-term use in CDI.…”

Section: Discussionmentioning

confidence: 99%

Desmopressin orally disintegrating tablet in Japanese patients with central diabetes insipidus: A retrospective study of switching from intranasal desmopressin

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Desmopressin orally disintegrating tablet in Japanese patients with central diabetes insipidus: A retrospective study of switching from intranasal desmopressin

et al. 2014

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“…S1-Desamino-8-D-arginine vasopressin (DDAVP), or desmopressin, is a synthetic vasopressin with antidiuretic properties and little to no vasopressor effect [81]. Desmopressin has affinity for the V 2 receptor 1.6 times that of AVP [82]. Thus, DDAVP administration may have benefit in counteracting caffeine-induced diuresis.…”

Section: What Is the Role Of Vasopressin Or Ddavp In Caffeine Toxicity?mentioning

confidence: 99%

Combined Butalbital/Acetaminophen/Caffeine Overdose: Case Files of the Robert Wood Johnson Medical School Toxicology Service

Bryczkowski

Geib

2012

J. Med. Toxicol.

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A 40-year-old woman with no previous medical problems presented to the Emergency Department (ED) 2 h after ingesting an unknown amount of Fioricet® (butalbital/acetaminophen/caffeine), oxycodone, and fentanyl patches about 90 min prior to emergency medical service (EMS) dispatch. The patient's husband reported they had had a fight, and he went down to the basement; when he came back upstairs, he found the patient unconscious with an empty pill bottle. A call to the patient's pharmacy by ED staff revealed that the patient had her prescription for butalbital/acetaminophen/caffeine tablets refilled 5 days earlier and that she had convinced the pharmacist to override the refill amount to dispense 540 tablets; according to the pharmacist, the patient stated she was going on a trip to Italy and needed a 6-month supply. EMS personnel removed a fentanyl patch (unknown strength) from her skin. The source of the fentanyl and the strength and formulation of the oxycodone were not recorded. Prehospital treatment included naloxone 4 mg IV without any noticeable clinical response, insertion of a nasal trumpet, and initiation of bag-valve-mask ventilation. A fingerstick glucose was 137 mg/dL.On arrival to the ED, the patient was unconscious with the following vital signs: blood pressure, 98/54 mmHg; pulse, 72 beats/min; respiratory rate, 14 breaths/min; and pulse oximetry, 100 % on a non-rebreather mask.

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“…In general, the polyuria associated with DI can usually be controlled by hormone replacement with AVP analogues that have potent anti-diuretic properties, such as desmopressin (dDAVP) (intranasal 5-20 lg once or twice per day; oral 0.05-0.8 mg in divided doses per day; and subcutaneous 1 lg every 12 h). 94,95 Desmopressin use is generally considered safe; however, it can be associated with an increased risk for development of hyponatremia, due to impaired free water excretion from non-suppressible AVP activity after administration, particularly if free water intake or administration is continued. 95,96 Additional medications, either alone or in combination with desmopressin, may occasionally be needed to control polyuria for the chronic management of central DI.…”

Section: Sodium Overloadmentioning

confidence: 99%

Les troubles de l’équilibre hydrosodé chez les patients hospitalisés

Bagshaw

Townsend

McDermid

2008

Can J Anesth/J Can Anesth

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Purpose To review and discuss the epidemiology, contributing factors, and approach to clinical management of disorders of sodium and water balance in hospitalized patients. Source An electronic search of the MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases and a search of the bibliographies of all relevant studies and review articles for recent reports on hyponatremia and hypernatremia with a focus on critically ill patients. Principal findings Disorders of sodium and water balance are exceedingly common in hospitalized patients, particularly those with critical illness and are often iatrogenic. These disorders are broadly categorized as hypo-osmolar or hyper-osmolar, depending on the balance (i.e., excess or deficit) of total body water relative to total body sodium content and are classically recognized as either hyponatremia or hypernatremia. These disorders may represent a surrogate for increased neurohormonal activation, organ dysfunction, worsening severity of illness, or progression of underlying chronic disease. Hyponatremic disorders may be caused by appropriately elevated (volume depletion) or inappropriately elevated (SIADH) arginine vasopressin levels, appropriately suppressed arginine vasopressin levels (kidney dysfunction), or alterations in plasma osmolality (drugs or body cavity irrigation with hypotonic solutions). Hypernatremia is most commonly due to unreplaced hypotonic water depletion (impaired mental status and/or access to free water), but it may also be caused by transient water shift into cells (from convulsive seizures) and iatrogenic sodium loading (from salt intake or administration of hypertonic solutions). Conclusion In hospitalized patients, hyponatremia and hypernatremia are often iatrogenic and may contribute to serious morbidity and increased risk of death. These disorders require timely recognition and can often be reversed with appropriate intervention and treatment of underlying predisposing factors.

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Drugs Five Years Later: Desmopressin

Cited by 273 publications

References 99 publications

Desmopressin orally disintegrating tablet in Japanese patients with central diabetes insipidus: A retrospective study of switching from intranasal desmopressin

Desmopressin orally disintegrating tablet in Japanese patients with central diabetes insipidus: A retrospective study of switching from intranasal desmopressin

Combined Butalbital/Acetaminophen/Caffeine Overdose: Case Files of the Robert Wood Johnson Medical School Toxicology Service

Les troubles de l’équilibre hydrosodé chez les patients hospitalisés

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