Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges

Dubin, Celina; Duca, Ester Del; Guttman‐Yassky, Emma

doi:10.2147/tcrm.s292504

Cited by 27 publications

(30 citation statements)

References 125 publications

(222 reference statements)

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“…8 Considering that JAK-inhibitors target several cytokine pathways instead of one single pathway, we hypothesized that this could be an effective therapy for the majority of CHE patients. 1,7 Our hypothesis was strengthened by previous literature on three different JAK-inhibitors that showed promising efficacy on CHE. Recently, two phase 3 trials with upadacitinib, an oral JAK-1 inhibitor, presented significant improvements in mild-to-severe CHE in patients with moderateto-severe AD compared to placebo at 16 weeks.…”

Section: Discussionsupporting

confidence: 52%

“… 8 Considering that JAK‐inhibitors target several cytokine pathways instead of one single pathway, we hypothesized that this could be an effective therapy for the majority of CHE patients. 1 , 7 …”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of CHE is not fully elucidated, although Th1, Th2, Th17, and Th22 signaling seem to play a role. The JAK–STAT signaling pathway is involved in the signaling of several cytokines that have been shown to play a role in the pathophysiology of atopic CHE, such as interleukin (IL) 4, IL‐13, IL‐22 and IL‐31, 7,8 and hyperkeratotic CHE, such as IL‐1, IL‐17, and interferon‐gamma 8 . Considering that JAK‐inhibitors target several cytokine pathways instead of one single pathway, we hypothesized that this could be an effective therapy for the majority of CHE patients 1,7 …”

Section: Discussionmentioning

confidence: 99%

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Baricitinib treatment of severe chronic hand eczema: Two case reports

2022

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Baricitinib treatment of severe chronic hand eczema: Two case reports

2022

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“…Существует значительная неудовлетворенная потребность в эффективных терапевтических стратегиях долгосрочного контроля за течением хронической экземы. Согласно статистическим данным после 5 лет лечения различными топическими средствами примерно 65% пациентов имеют непрерывно рецидивирующее течение [4,23,24]. Топические глюкокортикостероиды (ГКС) на сегодняшний день являются средством выбора для лечения хронической экземы кистей рук [22][23][24][25].…”

Section: лечениеunclassified

“…Согласно статистическим данным после 5 лет лечения различными топическими средствами примерно 65% пациентов имеют непрерывно рецидивирующее течение [4,23,24]. Топические глюкокортикостероиды (ГКС) на сегодняшний день являются средством выбора для лечения хронической экземы кистей рук [22][23][24][25]. Однако длительное применение топических ГКС может препятствовать восстановлению рогового слоя эпидермиса за счет нарушения синтеза липидов и вызывать атрофию кожи [26].…”

Section: лечениеunclassified

Steroid-refractory hand eczema: treatment experience

et al. 2022

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Hand eczema is a common multi-etiological disease manifested by evolutionary polymorphism of rashes. Hand eczema develops against the background of altered reactivity and genetic predisposition under the adverse effects of endogenous and exogenous factors. Hand eczema has a chronic course and is characterized by a wide range of clinical manifestations. The prevalence of eczematous lesions of the hands among the adult population is 1–2%, and among all skin diseases – 30–40%. The disease has an extremely negative impact on the quality of life, ability to work, career prospects and the social status of a person. The long course of eczematous lesions of the hands can be complicated by a secondary infection: bacterial and mycotic flora. Therefore, choosing the right and effective treatment for hand eczema is a particularly difficult task for a dermatologist. In recent years, a multicomponent drug based on gentamicin sulfate, dexpanthenol, mometasone furoate and econazole nitrate has been widely used for the treatment of hand eczema due to its high efficacy, tolerability, and safety. The use of this multicomponent drug in monotherapy for hand eczema is effective, leads to clinical remission and restoration of the quality of life of patients and is not accompanied by side effects and complications. This review focuses on the epidemiology, clinical features, and treatment options for hand eczema. Clinical experience with the use of a multicomponent drug in patients with hand eczema complicated by infection is also given.

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Eczematous Disorders

Mughal,

Ingram

2024

Rook's Textbook of Dermatology

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Eczematous disorders comprise manifestations of inflammatory skin conditions that may be aspects of atopic dermatitis, contact dermatitis or other conditions that in the main have an eczema‐like nature in both their presentation and response to treatment. Eczema and its management is covered in other chapters of this book. However, it is useful to consider the common aspects of nummular eczema, asteatotic eczema, lichenification and erythroderma in more detail together as sometimes the distinction between diagnoses is difficult with considerable overlap. Infectious eczema, whilst sharing physical characteristics with other eczemas, will respond differently to treatments. There are differences in how eczema presents on the hands, lower legs and the eyelids. Finally some other eczematous conditions are covered such as pityriasis alba and post‐traumatic eczema.

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Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges

Cited by 27 publications

References 125 publications

Baricitinib treatment of severe chronic hand eczema: Two case reports

Baricitinib treatment of severe chronic hand eczema: Two case reports

Steroid-refractory hand eczema: treatment experience

Eczematous Disorders

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