Drugs in Anaesthesia and Intensive Care: Fifth Edition

Holland, Darren

doi:10.1007/s12630-016-0750-7

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2022

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“…5,15,45,51,54,61,81 While LPCs bind to some of these ion channels, the LPC-evoked activation of the two-pore domain mechanogated potassium channels and TRPM8 is blocked by chlorpromazine, which, in addition to interacting with various receptors, also acts as a negative membrane curvature agent. 15,30,31,48,70,81 Presently, we demonstrate that chlorpromazine, similar to capsazepine and tranilast, significantly reduces 18:0 LPC-evoked activation of primary sensory neurons. This is consistent with increased lateral pressure by 18:0 LPC activating TRPV1 and TRPV2 in primary sensory neurons.…”

Section: Discussionmentioning

confidence: 59%