Drugs in infertility and fetal safety

Elizur, Shai E.; Tulandi, Togas

doi:10.1016/j.fertnstert.2008.02.092

Cited by 68 publications

(36 citation statements)

References 75 publications

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“…Our observations using Polscope imaging suggest that superovulation with letrozole does not increase the risk of aneuploidies or chromosomal defects. This is supported by work of other researchers who have reported that letrozole does not appear to be teratogenic (37) and is safe for both mother and fetus (38).…”

Section: Figuresupporting

confidence: 78%

Analysis of spindle characteristics and embryo quality in mice stimulated with letrozole using Polscope imaging

Ganesh

Chattopadhyay

Babu

et al. 2010

Fertility and Sterility

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Section: Figuresupporting

confidence: 78%

Analysis of spindle characteristics and embryo quality in mice stimulated with letrozole using Polscope imaging

Ganesh

Chattopadhyay

Babu

et al. 2010

Fertility and Sterility

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“…Overall, however, from the studies done so far, it seems that the risk of birth defects in children conceived by ART is very small, just 1-2% greater than reported in naturally conceived children (Elizur & Tulandi 2008). However, follow-up studies in adulthood are crucial for a real evaluation of possible long-term effects of ART.…”

Section: Perinatal Outcomesmentioning

confidence: 98%

“…Nevertheless, none of the studies looked into a possible association between the administration of drugs used for ovarian stimulation and the incidence of congenital diseases. Data from a meta-analysis by Elizur & Tulandi (2008) suggest that the risk of congenital diseases caused by drugs commonly used in infertility treatments such as aromatase inhibitors, GNRH agonists and antagonists, oestrogen and progesterone may be null or minimal. Clomiphene treatment was the only exception, as it might be associated with a slightly higher risk of neural tube defect and hypospadia.…”

Section: Perinatal Outcomesmentioning

confidence: 99%

“…Clomiphene was the only drug associated with a slightly higher risk of neural tube defect and hypospadia Elizur & Tulandi (2008) The overall increased risk of congenital diseases in children conceived by ART is 1-2% Elizur & Tulandi (2008) pregnancy and delivery rates (Staessen et al 2004, Mastenbroek et al 2007). This could be explained by possible damage to the embryo during blastomere biopsy; limitations of FISH technology (only a few chromosomes can be analysed); and the phenomenon of chromosomal mosaicism (Devroey & Fauser 2007).…”

Section: Parameters Correlated With Ovarian Stimulation Main Outcomesmentioning

confidence: 99%

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The impact of ovarian stimulation for IVF on the developing embryo

Santos¹,

Kuijk²,

Macklon³

2010

Reproduction

175

128

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The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1-3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes. In this review, we consider the evidence for these effects and address possible underlying mechanisms. We conclude that such mechanisms are still poorly understood, and further knowledge is needed in order to increase the safety of ovarian stimulation and to reduce potential effects on embryo development and implantation, which will ultimately be translated into increased pregnancy rates and healthy offspring.

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“…Current studies have shown that Letrozole is generally safe for use in pregnancy [17]. Known complications of Clomiphene citrate use include multifetal pregnancy and pregnancy wastage.…”

Section: Number Of Pregnanciesmentioning

confidence: 99%