Drugs Inducing Insomnia as an Adverse Effect

Malangu, Ntambwe

doi:10.5772/30921

Cited by 5 publications

(3 citation statements)

References 84 publications

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“…Insomnia is a core secondary symptom of depression in the Diagnostic and Statistical Manual of Mental Disorders diagnostic criteria of major depressive disorder ( 20 ). Another possible differential is drug-induced insomnia and/or depression, as medications commonly administered to lupus patients (corticosteroids such as prednisone) may trigger both sleep disruption and depressive symptoms ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

ChatGPT is not ready yet for use in providing mental health assessment and interventions

Dergaa,

Fekih-Romdhane,

Hallit

et al. 2024

Front. Psychiatry

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BackgroundPsychiatry is a specialized field of medicine that focuses on the diagnosis, treatment, and prevention of mental health disorders. With advancements in technology and the rise of artificial intelligence (AI), there has been a growing interest in exploring the potential of AI language models systems, such as Chat Generative Pre-training Transformer (ChatGPT), to assist in the field of psychiatry.ObjectiveOur study aimed to evaluates the effectiveness, reliability and safeness of ChatGPT in assisting patients with mental health problems, and to assess its potential as a collaborative tool for mental health professionals through a simulated interaction with three distinct imaginary patients.MethodsThree imaginary patient scenarios (cases A, B, and C) were created, representing different mental health problems. All three patients present with, and seek to eliminate, the same chief complaint (i.e., difficulty falling asleep and waking up frequently during the night in the last 2°weeks). ChatGPT was engaged as a virtual psychiatric assistant to provide responses and treatment recommendations.ResultsIn case A, the recommendations were relatively appropriate (albeit non-specific), and could potentially be beneficial for both users and clinicians. However, as complexity of clinical cases increased (cases B and C), the information and recommendations generated by ChatGPT became inappropriate, even dangerous; and the limitations of the program became more glaring. The main strengths of ChatGPT lie in its ability to provide quick responses to user queries and to simulate empathy. One notable limitation is ChatGPT inability to interact with users to collect further information relevant to the diagnosis and management of a patient’s clinical condition. Another serious limitation is ChatGPT inability to use critical thinking and clinical judgment to drive patient’s management.ConclusionAs for July 2023, ChatGPT failed to give the simple medical advice given certain clinical scenarios. This supports that the quality of ChatGPT-generated content is still far from being a guide for users and professionals to provide accurate mental health information. It remains, therefore, premature to conclude on the usefulness and safety of ChatGPT in mental health practice.

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Section: Discussionmentioning

confidence: 99%

ChatGPT is not ready yet for use in providing mental health assessment and interventions

Dergaa,

Fekih-Romdhane,

Hallit

et al. 2024

Front. Psychiatry

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“…Edema terjadi pada tungkai kaki kiri pasien dan membuat pasien cukup sulit untuk menggerakkan kakinya. Fenomena ini juga dilaporkan pada beberapa penelitian lain [31][32]. Berdasarkan Algoritma Naranjo, skor total nya adalah 6 yaitu probable (kemungkinan besar terjadi efek samping obat).…”

Section: Diduga Pasien Mengalami Mual Karena Efek Samping Dari Mekanisme Kerja Aspirin Yang Dapat Mengiritasi Lambungunclassified

Pengembangan Instrumen Pemantauan Efek Samping Obat: Efek Samping Obat Pada Pasien Strok Iskemik

et al. 2019

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Stroke iskemik merupakan penyakit vaskular yang terjadi ketika pasokan darah ke otak berkurang akibat penyumbatan pembuluh darah. Pengobatan stroke menggunakan beberapa obat seperti antiplatelet, antihipertensi dan antihiperlipidemia. Salah satu masalah penggunaan obat adalah timbulnya efek samping. Penelitian ini bertujuan untuk mengkaji efek samping obat pada pasien stroke iskemik di instalasi rawat inap Neurologi suatu rumah sakit pemerintah di Padang. Penelitian dilakukan secara prospektif selama 3 bulan. Data diambil dari rekam medis pasien dan hasil wawancara dengan pasien stroke iskemik yang telah menggunakan obat selama lebih dari 3 hari dan terdapat 32 orang pasien termasuk dalam kriteria inklusi. Obat-obat yang diamati adalah aspirin, klopidogrel, amlodipin, bisoprolol dan simvastatin. Efek samping obat yang dicurigai dianalisis dengan algoritma Naranjo dan disesuaikan dengan skala potensi efek samping obat. Hasil penelitian menunjukkan 11 pasien yang diduga mengalami efek samping obat. Terdapat 6 pasien (54,5 %) mengalami anemia, urtikaria, nausea dan insomnia yang disebabkan penggunaan obat aspirin, 3 pasien (27,3 %) mengalami nausea, edema dan insomnia yang disebabkan penggunaan obat amlodipin, 1 pasien (9,1 %) mengalami rash yang disebabkan penggunaan obat klopidogrel dan 1 pasien (9,1 %) mengalami dispnea yang disebabkan penggunaan obat bisoprolol. Hasil penelitian ini menyimpulkan bahwa terdapat 6 dugaan efek samping obat termasuk kategori possible dan 5 dugaan efek samping obat kategori probable.

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“…15 Short acting benzodiazepines and hypnotics are also associated with rebound insomnia as a as a result of chronic use of the drugs. 17 Pharmacological treatment of insomnia is aimed at improving the quality of sleep. Currently, the European sleep research society has approved guidelines that are used in the treatment of insomnia.…”

Section: Introductionmentioning

confidence: 99%

Developing potential drugs for insomnia through computational analysis

Oronyi,

Kagia

2023

F1000Res

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Introduction: Insomnia is a condition that affects the quality of life of an individual. It is associated with a lack of sleep or interrupted sleep. If not managed, insomnia may end up causing conditions such as obesity, heart conditions, hypertension, and mental disorders. Lack of sleep is also associated with an increased risk of Alzheimer’s disease. There is, therefore, a need to develop a drug that manages insomnia with desirable clinical outcomes Methods: The canonical smiles of Zolpidem, Suvorexant, Ramelteon, and Triazolam were obtained from PubChem. The study used the online tool SwissSimilarity to identify structural analogs for Zolpidem, Suvorexant, Ramelteon, and Triazolam. The canonical smiles were copied to PubChem Sketcher were converted to a 2- dimensional (2D) format. The Avogadro was used to optimize the ligands. The respective receptors were obtained from the Protein Data Bank. Chimera was used to prepare the receptor and the docking, using AutoDock Vina. SwissADME and Protox server was used in the determination of the pharmacokinetics and toxicity profiles, respectively. Results: Docking scores, pharmacokinetics, and toxicity profiles of the analogs were recorded. Nine structural analogs from the ZINC database (ZINC000004222622, ZINC000003981996, ZINC000003825731, ZINC000000000903, ZINC000039247014, ZINC000010152022, ZINC000000347721, ZINC000065743121 ZINC000022054496) were found to have a better docking score, blood brain barrier permeability, Lipinski’s violations, synthesizability index, gastrointestinal tract absorption, p-glycoprotein substrate metabolism LD50 compared to the parent drug molecules. All the nine molecules had good synthesizability index, gastrointestinal absorption and zero Lipinski violations indicating good oral availability. Conclusions: Ramelteon analogs ZINC000004222622, ZINC000003981996, and ZINC000003825731, Triazolam drug-like molecules, ZINC000000000903, ZINC000039247014, ZINC000010152022, and ZINC000000347721 and Zolpidem drug-like molecules ZINC000065743121 and ZINC000022054496 were identified as the best compound bases on the pharmacokinetic binding to the respective receptors and toxicity profiles.

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Drugs Inducing Insomnia as an Adverse Effect

Cited by 5 publications

References 84 publications

ChatGPT is not ready yet for use in providing mental health assessment and interventions

ChatGPT is not ready yet for use in providing mental health assessment and interventions

Pengembangan Instrumen Pemantauan Efek Samping Obat: Efek Samping Obat Pada Pasien Strok Iskemik

Developing potential drugs for insomnia through computational analysis

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