2000
DOI: 10.1016/s0166-4328(00)00212-6
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Drugs selective for nicotinic receptor subtypes: a real possibility or a dream?

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Cited by 49 publications
(32 citation statements)
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“…Clear identification of the receptor subtypes underlying the beneficial effects of nicotine is made more onerous by the current lack of truly selective compounds and the difficulties associated with producing nAChR subtype selective drugs (Gotti et al, 2000;Broad et al, 2002). It has therefore been suggested that a combined approach of pharmacological interventions and transgenic animals may help delineate the nAChR subtypes involved (Gotti et al, 2000;Chapman, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Clear identification of the receptor subtypes underlying the beneficial effects of nicotine is made more onerous by the current lack of truly selective compounds and the difficulties associated with producing nAChR subtype selective drugs (Gotti et al, 2000;Broad et al, 2002). It has therefore been suggested that a combined approach of pharmacological interventions and transgenic animals may help delineate the nAChR subtypes involved (Gotti et al, 2000;Chapman, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…nAChRs are divided into muscle (␣1, ␤1, ␥/⑀, and ␦) and neuronal AChRs (␣2-10 and ␤2-4), and neuronal AChRs are further subdivided into those that form homomeric receptors when expressed in heterologous systems (␣7-10) and those that form heteromeric receptors (␣2-6 and ␤2-4 in different combinations) (Gotti et al, 2000). The ␣8 nAChR subunit has not been studied since it is only expressed in the chicken (Rubboli et al, 1994).…”
mentioning
confidence: 99%
“…Furthermore, there is a substantial interest in developing subtype-selective agonists and antagonists that may have potential as therapeutic agents (Gotti et al, 2000;Dwoskin and Crooks, 2001).…”
mentioning
confidence: 99%