2012
DOI: 10.1016/b978-0-444-59499-0.00037-4
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Drugs that act on the immune system: cytokines and monoclonal antibodies

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“…The recombinant form, called aldesleukin, differs from the natural cytokine by absence of glycan residues and at position 125 and the end terminal amino acid (Table 2). It has been applied clinically in a number of ways, particularly for melanoma and renal cell carcinoma, and from its earliest applications showed a wide range of the sort of side effects often seen with cytokines including fever, chills, myalgia, nausea, vomiting, diarrhea, hypotension, oliguria and edema [81,240,241] (Table 2) plus a number of more severe cardiovascular, hematologic [81], endocrine, kidney, central nervous system, infectious and cutaneous toxicities.…”
Section: Aldesleukinmentioning
confidence: 99%
“…The recombinant form, called aldesleukin, differs from the natural cytokine by absence of glycan residues and at position 125 and the end terminal amino acid (Table 2). It has been applied clinically in a number of ways, particularly for melanoma and renal cell carcinoma, and from its earliest applications showed a wide range of the sort of side effects often seen with cytokines including fever, chills, myalgia, nausea, vomiting, diarrhea, hypotension, oliguria and edema [81,240,241] (Table 2) plus a number of more severe cardiovascular, hematologic [81], endocrine, kidney, central nervous system, infectious and cutaneous toxicities.…”
Section: Aldesleukinmentioning
confidence: 99%