Drugs That Disturb Sleep and Wakefulness

Schweitzer, Paula K.

doi:10.1016/b978-1-4160-6645-3.00046-3

Cited by 28 publications

(22 citation statements)

References 206 publications

(194 reference statements)

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“…The long sleepers in our study were observed to be older and to take naps more frequently and were more likely to be receiving antihypertensive drug therapy than other participants. Antihypertensive drugs, particularly β-blockers, have been reported to have central nervous system effects, resulting in tiredness, fatigue, and sleep disorders in some individuals (19). …”

Section: Discussionmentioning

confidence: 99%

Sleep Duration, Lifestyle Intervention, and Incidence of Type 2 Diabetes in Impaired Glucose Tolerance

Tuomilehto

Peltonen²,

Partinen³

et al. 2009

Diabetes Care

104

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OBJECTIVEBoth short and long sleep duration have frequently been found to be associated with an increased risk for diabetes. The aim of the present exploratory analysis was to examine the association between sleep duration and type 2 diabetes after lifestyle intervention in overweight individuals with impaired glucose tolerance in a 7-year prospective follow-up.RESEARCH DESIGN AND METHODSA total of 522 individuals (aged 40–64 years) were randomly allocated either to an intensive diet-exercise counseling group or to a control group. Diabetes incidence during follow-up was calculated according to sleep duration at baseline. Sleep duration was obtained for a 24-h period. Physical activity, dietary intakes, body weight, and immune mediators (C-reactive protein and interleukin-6) were measured.RESULTSInteraction between sleep duration and treatment group was statistically significant (P = 0.003). In the control group, the adjusted hazard ratios (HRs) (95% CI) for diabetes were 2.29 (1.38–3.80) and 2.74 (1.67–4.50) in the sleep duration groups 9–9.5 h and ≥10 h, respectively, compared with for that of the 7–8.5 h group. In contrast, sleep duration did not influence the incidence of diabetes in the intervention group; for sleep duration groups 9–9.5 h and ≥10 h, the adjusted HRs (95% CI) were 1.10 (0.60–2.01) and 0.73 (0.34–1.56), respectively, compared with that in the reference group (7–8.5 h sleep). Lifestyle intervention resulted in similar improvement in body weight, insulin sensitivity, and immune mediator levels regardless of sleep duration.CONCLUSIONSLong sleep duration is associated with increased type 2 diabetes risk. Lifestyle intervention with the aim of weight reduction, healthy diet, and increased physical activity may ameliorate some of this excess risk.

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Section: Discussionmentioning

confidence: 99%

Sleep Duration, Lifestyle Intervention, and Incidence of Type 2 Diabetes in Impaired Glucose Tolerance

Tuomilehto

Peltonen²,

Partinen³

et al. 2009

Diabetes Care

104

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“…76,77 These agents act through a variety of neurotransmitter pathways, receptors, and modulators. Although the interplay of these medications with sleep is difficult to study in ICU patients, their effects in normal participants has been well described.…”

Section: Sleep In the Icumentioning

confidence: 99%

Sleep Deprivation in Critical Illness

Kamdar

Needham

Collop

2011

J Intensive Care Med

363

182

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Critically ill patients frequently experience poor sleep, characterized by frequent disruptions, loss of circadian rhythms, and a paucity of time spent in restorative sleep stages. Factors that are associated with sleep disruption in the intensive care unit (ICU) include patient-ventilator dysynchrony, medications, patient care interactions, and environmental noise and light. As the field of critical care increasingly focuses on patients' physical and psychological outcomes following critical illness, understanding the potential contribution of ICU-related sleep disruption on patient recovery is an important area of investigation. This review article summarizes the literature regarding sleep architecture and measurement in the critically ill, causes of ICU sleep fragmentation, and potential implications of ICU-related sleep disruption on patients' recovery from critical illness. With this background information, strategies to optimize sleep in the ICU are also discussed.

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“…However, because GAD symptoms are heterogeneous, pharmacotherapy may attenuate one symptom yet exacerbate another. For instance, selective serotonin reuptake inhibitors, such as escitalopram, reduce GAD symptoms but have the capacity to exacerbate sleep disturbances (Schweitzer, 2000). Thus, similarly effective treatments with less risk of side effects (e.g., dizziness, loss of libido) are preferable.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise on sleep among young women with Generalized Anxiety Disorder

Herring

Kline

O’Connor

2015

Mental Health and Physical Activity

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Statement of the Problem Generalized Anxiety Disorder (GAD) and disturbed sleep are prevalent, debilitating, and frequently comorbid problems for which successful treatment remains limited. Exercise can promote sleep but whether it does among GAD patients is unknown. Methods Thirty sedentary women (18–37y) with a primary DSM-IV diagnosis of GAD were randomized to six weeks of resistance (RET) or aerobic exercise training (AET), or waitlist (WL). RET and AET involved twice-weekly sessions of either lower-body weightlifting or leg cycling matched on multiple features of exercise. Outcomes included total sleep time (TST), lights out time, awakening out of bed time, time in bed (TIB), sleep onset latency (SOL), wakefulness after sleep onset, and sleep efficiency. Hedges’ d effect sizes and 95% confidence intervals were calculated for each exercise condition compared to WL. Regression examined baseline associations between anxiety and sleep and associated change. Results Twenty-two of 26 participants reported poor baseline sleep (Pittsburgh Sleep Quality Index >5). RET significantly decreased weekend TIB (d=−1.79; [−2.89, −0.70]) and SOL (d=−1.30; [−2.32, −0.28]), and significantly increased weekend sleep efficiency (d=1.30; [0.29,2.32]). AET significantly reduced weekend TIB (d=−1.13; [−2.16, −0.11]) and SOL (d=−1.08; [−2.09, −0.06]). Reduced GAD clinical severity rating was significantly associated with improved weekend sleep efficiency among RET (t6=−3.48, p≤0.013). Conclusions Short-term exercise training improves sleep outcomes among GAD patients, especially for RET and weekend sleep. Findings suggest improved sleep may be associated with reduced clinical severity among GAD patients.

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Drugs That Disturb Sleep and Wakefulness

Cited by 28 publications

References 206 publications

Sleep Duration, Lifestyle Intervention, and Incidence of Type 2 Diabetes in Impaired Glucose Tolerance

Sleep Duration, Lifestyle Intervention, and Incidence of Type 2 Diabetes in Impaired Glucose Tolerance

Sleep Deprivation in Critical Illness

Effects of exercise on sleep among young women with Generalized Anxiety Disorder

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