Drugs used in childhood idiopathic or benign intracranial hypertension

Matthews, Yim-Yee

doi:10.1136/adc.2006.107326

Cited by 49 publications

(19 citation statements)

References 87 publications

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“…Symptoms caused by increased cerebrospinal fluid pressure are not characteristic and include headaches, nausea, vomitus, transient visual obscurations, sixth nerve palsy with horizontal diplopia, and tinnitus (Matthews, 2008).…”

Section: Clinical Symptoms Of Iihmentioning

confidence: 99%

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The Importance of Toxoplasma Gondii Infection in Diseases Presenting With Headaches. Headaches and Aseptic Meningitis May Be Manifestations of the Jarisch-Herxheimer Reaction

Prandota

2009

International Journal of Neuroscience

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Worldwide, approximately 2 billion people are chronically infected with T. gondii with largely unknown consequences. This review presents clinical symptoms, differential diagnosis, triggering factors, treatment, and pathomechanisms responsible for idiopathic intracranial hypertension, pseudotumor cerebri, and aseptic meningitis. Literature cited in this work illustrates that immune state and other biologic mediator imbalances due to various endogenous and exogenous triggering factors may markedly affect latent central nervous system T. gondii infection/inflammation intensity, and cause reactivation of cerebral toxoplasmosis (CT). Irregularities in pro- and anti-inflammatory processes may markedly disturb the host and/or T. gondii defense mechanisms important for immune control of the parasite thereby manifesting as a wide range of neurologic symptoms and signs observed in some patients with migraine, epilepsy, celiac disease, Henoch-Schönlein purpura, and other brain disorders. This is consistent with reactivation of CT in mice after treatment with dexamethasone associated with depression of type T(H)1 immune response, and development of CT after administration of etanercept or other bioproducts. It seems that various types of headaches, epilepsy, aseptic meningitis, systemic adverse reactions to drugs or other substances represent the Jarisch-Herxheimer reaction due to apoptosis of T. gondii tachyzoites. Also development of some brain tumors, such as ependymoma and glioma may be associated with a chronic course of CT. Thus, all these patients should be tested for T. gondii infection.

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Section: Clinical Symptoms Of Iihmentioning

confidence: 99%

“…In one study performed Table 2. Clinical symptoms and signs of idiopathic intracranial hypertension (Matthews, 2008) Symptoms of intracranial hypertension Vision related symptoms and signs…”

Section: Clinical Symptoms Of Iihmentioning

confidence: 99%

The Importance of Toxoplasma Gondii Infection in Diseases Presenting With Headaches. Headaches and Aseptic Meningitis May Be Manifestations of the Jarisch-Herxheimer Reaction

Prandota

2009

International Journal of Neuroscience

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“…Recommended starting dose is 25 mg/kg/ day given in three to four divided doses, with maximum dose of 100 mg/kg/day or 2 grams/ day (Matthews YY, 2008). Steroids are used in the treatment of IIH but their mechanism of action is not clear.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic Intracranial Hypertension in a pubertal paediatric Indian patient

et al. 2017

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Background: Idiopathic Intracranial Hypertension (IIH) is characterised by raised intracranial pressure (ICP) with normal cerebrospinal fluid (CSF) composition and absence of hydrocephalus or space occupying lesions. IIH is a rare disease in children. It can lead to visual impairment but prompt diagnosis and treatment in most of the cases will prevent potentially permanent visual loss. Objective: To report a rare case of Idiopathic Intracranial Hypertension in a pubertal child, clinical features, and findings of Magnetic Resonance Imaging (MRI) and visual field of this case. Case: An adolescent girl aged 14 years presented with headache and transient visual obscuration for two weeks. On examination, findings (fundus, visual field and MRI) were suggestive of Idiopathic intracranial hypertension. She did not have any classical predisposing risk factors. She recovered very well with acetazolamide and short term steroid therapy with no sequelae and clinical recurrence over a follow up of 12 months. Conclusion: This is a rare case of IIH in a child, which was confirmed on the MRI and visual field testing.

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“…Acetazolamide has demonstrated decreased CSF production by 6%-57% in humans, and is typically used as first-line medical treatment (McCarthy & Reed, 1974). Case studies have demonstrated efficacy of acetazolamide in improving IIH symptoms, stabilizing vision, and reducing recurrences (Kesler, Hadayer, & Goldhammer, 2004;Matthews;Warman, 2000;Youroukos et al, 2000). Methazolamide is another carbonic anhydrase inhibitor that has been used as well.…”

Section: Treatmentmentioning

confidence: 97%

“…Furosemide is a loop diuretic that is frequently used as an adjunct in IIH treatment, and has demonstrated some efficacy in small case series (Matthews;Corbett & Thompson, 1989). Although controversial, corticosteroids have been used as a temporizing measure with some success in patients with fulminant hypertension (Liu, Glaser, & Schatz, 1994).…”

Section: Treatmentmentioning

confidence: 98%

More Than Meets The Eye? Redefining Idiopathic Intracranial Hypertension

Kapoor

2010

International Journal of Neuroscience

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Idiopathic intracranial hypertension (IIH) is a disease of unknown etiology associated with increased intracranial pressure, predominantly affecting obese females of childbearing age. The history of IIH is quite unique, featuring only limited advancements in evidenced-based treatments, but boasting literally countless changes in nomenclature, proposed etiology, and conceptual approach. Despite its elusive pathogenesis, an evolution of our approach to IIH can be traced sequentially through identifiable periods. Contemporary research suggests that we are approaching a new phase in IIH, redefining it as a global neurologic syndrome with more far-reaching effects than previously realized.

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Drugs used in childhood idiopathic or benign intracranial hypertension

Cited by 49 publications

References 87 publications

The Importance of Toxoplasma Gondii Infection in Diseases Presenting With Headaches. Headaches and Aseptic Meningitis May Be Manifestations of the Jarisch-Herxheimer Reaction

The Importance of Toxoplasma Gondii Infection in Diseases Presenting With Headaches. Headaches and Aseptic Meningitis May Be Manifestations of the Jarisch-Herxheimer Reaction

Idiopathic Intracranial Hypertension in a pubertal paediatric Indian patient

More Than Meets The Eye? Redefining Idiopathic Intracranial Hypertension

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