Dry‐cured ham tissue characterization by fast field cycling NMR relaxometry and quantitative magnetization transfer

Bajd, Franci; Gradišek, Anton; Apih, T.; Serša, Igor

doi:10.1002/mrc.4462

Cited by 17 publications

(3 citation statements)

References 36 publications

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“…The observations reported here have been made both in a qualitative way and following a thorough quantitative analysis of the shapes of the relaxation dispersion profiles using a model-free approach based on three dynamical processes in the tissues. The QRE effects observed in tissues are, as expected from the literature 23 , 48 , 50 – 52 , associated with 14 N nuclei present in protein backbones. This exploratory study has shed light on FFC-NMR as a new source of information in the context of sarcoma, and potentially for oncology and other pathological processes affecting tissue structures in general.…”

Section: Discussionsupporting

confidence: 85%

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Masiewicz

Ashcroft

Boddie

et al. 2020

Sci Rep

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This work explores what Fast Field-Cycling Nuclear Magnetic Resonance (FFC-NMR) relaxometry brings for the study of sarcoma to guide future in vivo analyses of patients. We present the results of an ex vivo pilot study involving 10 cases of biopsy-proven sarcoma and we propose a quantitative method to analyse 1 H NMR relaxation dispersion profiles based on a model-free approach describing the main dynamical processes in the tissues and assessing the amplitude of the Quadrupole Relaxation Enhancement effects due to 14 N. This approach showed five distinct groups of dispersion profiles indicating five discrete categories of sarcoma, with differences attributable to microstructure and rigidity. Data from tissues surrounding sarcomas indicated very significant variations with the proximity to tumour, which may be attributed to varying water content but also to tissue remodelling processes due to the sarcoma. This pilot study illustrates the potential of FFC relaxometry for the detection and characterisation of sarcoma. Magnetic Resonance Imaging (MRI) is a powerful method used in the medical diagnosis of a range of different soft tissue pathologies. The principle of MRI lies in detecting differences in the behaviour of nuclear spins (in most cases from 1 H) between pathological tissues and their healthy counterparts, which can be exploited as a source of contrast to form images. Spin-lattice and spin-spin relaxation times, denoted as T 1 and T 2 respectively, are two important sources of MRI contrast that describe how fast tissues return to magnetic equilibrium after excitation. To simplify calculations one often uses their reciprocal values, R 1 = 1/T 1 and R 2 = 1/T 2 , which are referred to as spin-lattice and spin-spin relaxation rates, respectively 1-3 but convey the same information. R 1 usually shows much better contrast at fields below 0.5 T but most clinical scanners operate at 1.5 T or 3 T to achieve high spatial resolution. Paramagnetic contrast agents are commonly used to improve contrast 4,5 , providing relaxation enhancement caused by strong magnetic dipole-dipole interactions between protons (hydrogen nuclei, 1 H) from the tissues and the paramagnetic centre (typically gadolinium or manganese ions). Despite the huge progress in advanced contrast agents and MRI technology, the early diagnosis and treatment of patients with musculoskeletal (MSK) malignancies (sarcomas) remains a major challenge. Initial detection of MSK malignancies depends upon clinical examination, fine needle aspiration cytology or core biopsy and MRI. MRI is also used in the follow-up and surveillance of patients with suspected local recurrence following treatment. Unfortunately, the imaging characteristics of tissues using conventional MRI are not diagnostic for a large number of soft tissue tumours and therefore careful multidisciplinary interpretation of the combined results are required in reaching a final diagnosis. Despite this, it can still be challenging to estimate tumour aggressiveness or resection margins.

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Section: Discussionsupporting

confidence: 85%

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Masiewicz

Ashcroft

Boddie

et al. 2020

Sci Rep

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“…Steele et al (2016) monitored the aging of banana and spoilage of milk during storage by FFC-NMR relaxometry [32]. Phenolic analysis of the fresh and withered blueberries [33], characterisation of dry cured ham [34] and differentiation of pistachio oils [35] are also among the rare studies that used FFC techniques for food science applications. One should also mention the recent works [36][37][38] devoted to cheese, eggs and gelatin products, respectively, as they include a thorough, quantitative analysis of NMR relaxometry data, showing the potential of this method for food science.…”

Section: Introductionmentioning

confidence: 99%

Water Dynamics in Whey-Protein-Based Composite Hydrogels by Means of NMR Relaxometry

Özel

Kruk

Wojciechowski

et al. 2021

IJMS

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Whey-protein-isolate-based composite hydrogels with encapsulated black carrot (Daucus carota) extract were prepared by heat-induced gelation. The hydrogels were blended with gum tragacanth, pectin and xanthan gum polysaccharides for modulating their properties. 1H spin-lattice relaxation experiments were performed in a broad frequency range, from 4 kHz to 30 MHz, to obtain insight into the influence of the different polysaccharides and of the presence of black carrot on dynamical properties of water molecules in the hydrogel network. The 1H spin-lattice relaxation data were decomposed into relaxation contributions associated with confined and free water fractions. The population of the confined water fraction and the value of the translation diffusion coefficient of water molecules in the vicinity of the macromolecular network were quantitatively determined on the basis of the relaxation data. Moreover, it was demonstrated that the translation diffusion is highly anisotropic (two-dimensional, 2D).

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“…FFC‐MR relaxometry is an approach to directly measure NMR relaxation properties . FFC‐MRI combines the techniques of field‐cycling nuclear MR relaxometry with the imaging methods of MRI, offering access to biological information not available from conventional imaging at a fixed field strength .…”

Section: Introductionmentioning

confidence: 99%

Nuclear magnetic relaxation dispersion of murine tissue for development of T₁ (R₁) dispersion contrast imaging

Araya

Martinez-Santiesteban

Handler

et al. 2017

NMR in Biomedicine

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This study quantified the spin-lattice relaxation rate (R 1 ) dispersion of murine tissues from 0.24 mT to 3 T. A combination of ex vivo and in vivo spin-lattice relaxation rate measurements were acquired for murine tissue. Selected brain, liver, kidney, muscle, and fat tissues were excised and R 1 dispersion profiles were acquired from 0.24 mT to 1.0 T at 37°C, using a fast field-cycling MR (FFC-MR) relaxometer. In vivo R 1 dispersion profiles of mice were acquired from 1.26 T to 1.74 T at 37°C, using FFC-MRI on a 1.5 T scanner outfitted with a field-cycling insert electromagnet to dynamically control B 0 prior to imaging. Images at five field strengths (1.26, 1.39, 1.5, 1.61, 1.74 T) were acquired using a field-cycling pulse sequence, where B 0 was modulated for varying relaxation durations prior to imaging. R 1 maps and R 1 dispersion (ΔR 1 /ΔB 0 ) were calculated at 1.5 T on a pixel-by-pixel basis. In addition, in vivo R 1 maps of mice were acquired at 3 T. At fields less than 1 T, a large R 1 magnetic field dependence was observed for tissues. ROI analysis of the tissues showed little relaxation dispersion for magnetic fields from 1.26 T to 3 T. Our tissue measurements show strong R 1 dispersion at field strengths less than 1 T and limited R 1 dispersion at field strengths greater than 1 T. These findings emphasize the inherent weak R 1 magnetic field dependence of healthy tissues at clinical field strengths. This characteristic of tissues can be exploited by a combination of FFC-MRI and T 1 contrast agents that exhibit strong relaxivity magnetic field dependences (inherent or by binding to a protein), thereby increasing the agents' specificity and sensitivity. This development can provide potential insights into protein-based biomarkers using FFC-MRI to assess early changes in tumour development, which are not easily measureable with conventional MRI. MRI has a history of constant technical progress towards higher magnetic field strengths for imaging. 1 The progressive increases in magnetic field strength have been spurred by significant gains in the signal-to-noise ratio (SNR), and spectral and spatial resolution exploited in imaging of anatomy and brain function. [2][3][4][5] While high and ultra-high magnetic field strengths are attractive for producing exquisite images of internal structures with unprecedented detail that aid in tissue characterization, imaging at these magnetic field strengths results in very little difference in the relaxation times of different tissues, thereby losing the variability of an important intrinsic tissue property that leads to image contrast. 6,7 Differences in Abbreviations used: B P , polarization magnetic field; B R , relaxation magnetic field; dreMR, delta relaxation enhanced MR; FFC-MR, fast field-cycling MR; FFC-MRI, fast field-cycling MRI; FID, free induction decay; FSE, fast spin-echo; NMRD, nuclear magnetic relaxation dispersion; NP, non-polarized; PP, pre-polarized; ROI, region of interest; SNR, signal-to-noise ratio

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Dry‐cured ham tissue characterization by fast field cycling NMR relaxometry and quantitative magnetization transfer

Cited by 17 publications

References 36 publications

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Water Dynamics in Whey-Protein-Based Composite Hydrogels by Means of NMR Relaxometry

Nuclear magnetic relaxation dispersion of murine tissue for development of T₁ (R₁) dispersion contrast imaging

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Dry‐cured ham tissue characterization by fast field cycling NMR relaxometry and quantitative magnetization transfer

Cited by 17 publications

References 36 publications

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Water Dynamics in Whey-Protein-Based Composite Hydrogels by Means of NMR Relaxometry

Nuclear magnetic relaxation dispersion of murine tissue for development of T1 (R1) dispersion contrast imaging

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Nuclear magnetic relaxation dispersion of murine tissue for development of T₁ (R₁) dispersion contrast imaging