Dry eye and its correlation to diabetes microvascular complications in people with type 2 diabetes mellitus

Najafi, Laily; Malek, Mojtaba; Valojerdi, Ameneh Ebrahim; Aghili, Rokhsareh; Khamseh, Mohammad E.; Fallah, A.; Tokhmehchi, Mohammad Reza Famil; Behrouz, Mahmoud Jabarvand

doi:10.1016/j.jdiacomp.2013.04.006

Cited by 92 publications

(95 citation statements)

References 33 publications

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“…Recently Ozawa et al in the years 2012 and 2015 strongly suggested that the severity of DR in males of T2D were attributed to abnormalities in neuroretinal function 16,18 . In our study frequency of DED was higher in T2D with DR, which was not noticed in previous studies [2][3][4][5] . 5 and strongly suggested that surveillance of diabetic patients and good control over blood glucose are necessary key factors for prevention of dry eye syndrome and retinopathy.…”

Section: Mean Values Of Fbs Ppbs and Hba1c By Sex And Its Associatiocontrasting

confidence: 93%

“…In our study frequency of DED was higher in T2D with DR, which was not noticed in previous studies [2][3][4][5] . 5 and strongly suggested that surveillance of diabetic patients and good control over blood glucose are necessary key factors for prevention of dry eye syndrome and retinopathy.…”

Section: Mean Values Of Fbs Ppbs and Hba1c By Sex And Its Associatiocontrasting

confidence: 93%

“…In consistent with this, a high incidence of dry eye among females as compared to males was reported 17 . Also many studies reported the significant correlation between DED and stages of DR [2][3][4][5] . From findings we inferred that DED is more prevalent among females with DR while the severity of DR was found high in males with less prevalence of DED when compared to females.…”

Section: Mean Values Of Fbs Ppbs and Hba1c By Sex And Its Associatiomentioning

confidence: 99%

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Type 2 diabetes (T2D) is one of the risk factor for dry eye disease (DED) and known factor for diabetic retinopathy (DR). There are few studies have been already reported the prevalence of DED nevertheless studies shown prevalence of DED and DR by sex in patients with T2D. The study was carried out with 100 T2D patients. DED was assessed with Tear break up time and Schirmer tests. All the subjects were examined by slit lamp bio-microscopy and colored fundus photographs. Diabetic retinopathy (DR) was graded according to early Treatment Diabetic Retinopathy (ETDRS) criteria. Out of 100 T2D patients, the prevalence of DED was noticed in 53 patients. Out of 53 DED cases, 14 (43.8%) were males and 39 (57.4%) were females. Next we assessed the association of DED with DR and it was found 47.6% in males and 69.4% in females. In our study, the prevalence of DED was high in T2D patients and showed to have a high correlation with DR. Prevalence of DED was more in females as compared to males with DR but severity of DR was more in males as compared to females with DR. As T2D and dry eye seems to have a common association, further studies are needed to establish the underlying etiologic relationship with large sample size. Ophthalmologists may increase their role to ensure comprehensive eye care to the people by examining dry eye which is an imperative part of the evaluation of diabetic eye disease.

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Section: Mean Values Of Fbs Ppbs and Hba1c By Sex And Its Associatiocontrasting

confidence: 93%

Section: Mean Values Of Fbs Ppbs and Hba1c By Sex And Its Associatiocontrasting

confidence: 93%

Section: Mean Values Of Fbs Ppbs and Hba1c By Sex And Its Associatiomentioning

confidence: 99%

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2017

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“…En nuestro estudio, además de la influencia de los cambios relacionados con el sexo, también podría estar influyendo que las mujeres tuvieron una mayor edad que los hombres, y tanto en nuestro estudio como en otros 4,25,26,31,34 la edad tiene una relación directamente proporcional con la enfermedad de la superficie ocular. Los pacientes que provenían de médicos con alta especialidad en retina y enfermedades inflamatorias oculares tuvieron los valores OSDI más bajos; esto pudiera deberse a que, aunque algunos autores han encontrado una mayor prevalencia de ojo seco y disfunción de glán-dulas de Meibomio en pacientes diabéticos [35][36][37] , quienes son la población con enfermedad retiniana más frecuente en México, Fuerst, et al…”

Section: Discussionunclassified

Prevalencia de síntomas de enfermedad de la superficie ocular en pacientes que acuden a consulta oftalmológica

Garza-León

Hernández-Quíntela

Cámara-Castillo

et al. 2017

GMM

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“…Comparing the proteins identified from tears using either capillary or Shirmer's strip have revealed that the number of proteins identified using Shirmer's strip for tears collection is higher [83] highlighting the more invasive feature of the method. Also it should be noted that the progression of diabetes is associated with dry eye disease, which is more prevalent in patients with PDR [84]. In these cases the collection of basal tears with glass capillary can be very problematic or even impossible [85].…”

Section: Tear Proteomics As a Tool In Dr Specific Biomarker Studiesmentioning

confidence: 99%

Diabetic retinopathy: Proteomic approaches to help the differential diagnosis and to understand the underlying molecular mechanisms

Csősz

Deák

Kalló

et al. 2017

Journal of Proteomics

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a b s t r a c t a r t i c l e i n f oDiabetic retinopathy is the most common diabetic eye disease and a leading cause of blindness among patients with diabetes. The appearance and the severity of the symptoms correlate with the duration of diabetes and poor blood glucose level management. Diabetic retinopathy is also categorized as a chronic low-level inflammatory disease; the high blood glucose level promotes the accumulation of the advanced glycation end products and leads to the stimulation of monocytes and macrophages. Examination of protein level alterations in tears using state-of the art proteomics techniques have identified several proteins as possible biomarkers for the different stages of the diabetic retinopathy. Some of the differentially expressed tear proteins have a role in the barrier function of tears linking the diabetic retinopathy with another eye complication of diabetes, namely the diabetic keratopathy resulting in impaired wound healing. Understanding the molecular events leading to the eye complications caused by hyperglycemia may help the identification of novel biomarkers as well as therapeutic targets in order to improve quality of life of diabetic patients. Biological significance: Diabetic retinopathy (DR), the leading cause of blindness among diabetic patients can develop without any serious symptoms therefore the early detection is crucial. Because of the increasing prevalence there is a high need for improved screening methods able to diagnose DR as soon as possible. The non-invasive collection and the relatively high protein concentration make the tear fluid a good source for biomarker discovery helping the early diagnosis. In this work we have reviewed the administration of advanced proteomics techniques used in tear biomarker studies and the identified biomarkers with potential to improve the already existing screening methods for DR detection.

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Dry eye and its correlation to diabetes microvascular complications in people with type 2 diabetes mellitus

Cited by 92 publications

References 33 publications

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Prevalencia de síntomas de enfermedad de la superficie ocular en pacientes que acuden a consulta oftalmológica

Diabetic retinopathy: Proteomic approaches to help the differential diagnosis and to understand the underlying molecular mechanisms

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