Dry eye disease management

Safir, Margarita; Twig, Gilad; Mimouni, Michael

doi:10.1136/bmj-2023-077344

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…1,2 More than a billion individuals worldwide suffer from DED, and the prevalence of DED was estimated to be 19−31% among the adult population under large cross-sectional studies. 3,4 The DED vicious cycle refers to a self-perpetuating sequence of events composed of inflammation, apoptosis, hyperosmolarity, and tear instability, and the deterioration of the interaction aggravates DED symptoms. 5 This multifactor-formed cycle causes the poor and unstable effectiveness of merely anti-inflammatory medications in clinics, so targeting the cause of DED is the principle of effective treatment and prevention of recurrence.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Dry eye disease (DED) is a chronic multifactorial ophthalmic disease caused by tear film instability and ocular surface microenvironment imbalance, which can be accompanied by ocular surface inflammation, tissue damage, and nerve abnormalities, mainly characterized by a range of ocular discomforts and even visual impairment. , More than a billion individuals worldwide suffer from DED, and the prevalence of DED was estimated to be 19–31% among the adult population under large cross-sectional studies. , The DED vicious cycle refers to a self-perpetuating sequence of events composed of inflammation, apoptosis, hyperosmolarity, and tear instability, and the deterioration of the interaction aggravates DED symptoms . This multifactor-formed cycle causes the poor and unstable effectiveness of merely anti-inflammatory medications in clinics, so targeting the cause of DED is the principle of effective treatment and prevention of recurrence. , …”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Cerium Oxide Nanozyme for Synergistic Dry Eye Disease Therapy

Zou,

Hong,

et al. 2024

ACS Appl. Mater. Interfaces

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multifunctional Cerium Oxide Nanozyme for Synergistic Dry Eye Disease Therapy

Zou,

Hong,

et al. 2024

ACS Appl. Mater. Interfaces

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Linarine inhibits inflammatory responses in dry eye disease mice by modulating purinergic receptors

Liu,

Jiang,

Tan

et al. 2024

Front. Immunol.

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BackgroundLinarine is a natural chemical component widely found in Buddleja officinalis Maxim., Chrysanthemum indicum L., Mentha canadensis L., and other medicinal plants. Modern pharmacological studies have shown that linarine with good anti-inflammatory and antioxidant activities can inhibit the proliferation and induce apoptosis of many kinds of tumor cells. Moreover, linarine showed protective effect on the liver, kidneys, and other organs.MethodsInflammation model of human corneal epithelial cell (HCEC) was constructed using NaCl induction, and cytotoxicity was detected by the CCK8 assay. The levels of inflammatory factors tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β) were measured using Enzyme-linked immunoassay (ELISA). Chronic painful stimulation (tail clamping) in combination with Benzalkonium Chloride Solution drops in a desiccator established a mouse model of dry eye disease (DED). The following parameters were recorded: body mass, anal temperature, tear secretion, tear film rupture time, and corneal fluorescein staining. The levels of inflammatory factors mitogen activated protein kinase (MAPK), nuclear factor kappa-B (NF-kB), c-Jun N-terminal kinase (JNK), IL-1β, Interleukin 18(IL-18), A2A, A3, P2X4, P2X7, P2Y1 were measured by using immunofluorescence (IF) staining.ResultsLinarine can inhibit the secreation of TNF-α, and IL-1β in HCECs. Linarine prolonged tear film rupture time, promoted tear secretion, repaired corneal damage, and reduced the levels of inflammatory factors of MAPK, NF-kB, JNK, IL-1β, IL-18, and modulated the levels of the purinergic receptor.ConclusionsLinarine is effective in treating dry eye in mice by inhibiting purinergic receptors-mediated inflammatory response.

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Managing Ocular Surface Disease in Glaucoma Treatment: A Systematic Review

Kemer,

Mekala,

Dave

et al. 2024

Bioengineering

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Ocular surface disease (OSD) is a frequent disabling challenge among patients with glaucoma who use benzalkonium chloride (BAK)-containing topical glaucoma medications for prolonged periods. In this comprehensive review, we evaluated the prevalence of OSD and its management, focusing on both current and future alternatives. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria were used to assess a) the impact of active ingredients and preservatives on the ocular surface and b) the efficacy of preservative-free (PF) alternatives and adjunctive therapies. BAK-containing glaucoma medications were found to significantly contribute to OSD by increasing corneal staining, reducing tear film stability, and elevating ocular surface disease index (OSDI) scores. Transitioning to PF formulations or those with less cytotoxic preservatives, such as Polyquad® and SofZia®, demonstrated a marked improvement in OSD symptoms. In particular, the use of adjunct cyclosporine A, through its anti-inflammatory and enhanced tear film stability actions, was shown to be very beneficial to the ocular surface. Therefore, the most effective management of OSD is multi-factorial, consisting of switching to PF or less cytotoxic medications, adjunct use of cyclosporine A, and early incorporation of glaucoma surgical treatments such as laser trabeculoplasty, trabeculectomy, glaucoma drainage devices, or minimally invasive glaucoma surgery (MIGS).

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Dry eye disease management

Cited by 3 publications

References 66 publications

Multifunctional Cerium Oxide Nanozyme for Synergistic Dry Eye Disease Therapy

Multifunctional Cerium Oxide Nanozyme for Synergistic Dry Eye Disease Therapy

Linarine inhibits inflammatory responses in dry eye disease mice by modulating purinergic receptors

Managing Ocular Surface Disease in Glaucoma Treatment: A Systematic Review

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