Dry Eye Disease: Present Challenges in the Management and Future Trends

Al-Saedi, Zahraa Hasan Falhi; Zimmerman, Allison; Bachu, Rinda Devi; Dey, Sangeeta; Shah, Zahoor A.; Baugh, Reginald F.; Boddu, Sai H. S.

doi:10.2174/1381612822666160614012634

Cited by 47 publications

(33 citation statements)

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“…Some conventional, prescribed and over‐the‐counter medications are used to relieve the DED symptoms. Short pharmacological duration of action and unwanted side‐effects of these drugs after long‐term use, however, may worsen the symptoms of the disease …”

Section: Discussionmentioning

confidence: 99%

“…Over the past decade, the administration of drugs through the nasal route has received significant attention as a convenient and reliable drug delivery method . The nasal cavity offers a number of specific advantages for systemic delivery, such as large surface area, porous endothelial membrane, high total blood flow, avoiding the first‐pass metabolism and ready accessibility.…”

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confidence: 99%

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Effects of intranasal administration of violet oil in dry eye disease

Shahroodi

Nejabat

Nimrouzi

et al. 2019

Clinical and Experimental Optometry

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Background: Dry eye disease is a disorder of the tear film. In this study, the effect of Viola odorata L. oily extract was examined for the treatment of patients suffering from dry eye disease. Methods: A randomised, double-blind, placebo-controlled study was designed. During the trial, Schirmer's test, tear breakup time, Oxford staining and the Ocular Surface Disease Index were assessed. Overall, 105 patients with dry eye symptoms between the ages of 18 and 60 years were allocated to the violet-almond oil, almond oil and placebo (1% w/v hydroxypropyl methylcellulose solution) groups. The treatment and placebo were administered intranasally, two drops three times a day for one month. The patients were followed up for four weeks. A total of 91 patients (32, 29 and 30 in the violet-almond oil, almond oil and placebo groups, respectively) completed the study. Results: At baseline, there was no difference between the three groups in terms of demographic data and the measurement parameters. After the intervention, the results revealed that the Schirmer's score without local anaesthesia and the tear breakup time results significantly improved in the violet-almond oil group. One-way ANOVA indicated a significant improvement in the Schirmer's score, tear breakup time and Ocular Surface Disease Index of the treatment group, as compared with the other groups (p < 0.05). However, the obtained results did not present any significant mean difference between and within the groups of the Oxford staining grade (p > 0.05). Conclusions: This trial showed that the intranasally administered V. odorata L. oily extract enhances tear production and improves tear film stability.

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Section: Discussionmentioning

confidence: 99%

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Effects of intranasal administration of violet oil in dry eye disease

Shahroodi

Nejabat

Nimrouzi

et al. 2019

Clinical and Experimental Optometry

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“…Our study showed that rabbits with DED induced by 0.1%BAC displayed higher IL-1β levels in the CJE and CE than rabbits with normal eyes. Hyperosmolarity is a non-microbial inducer of IL-1 [30], and tear hyperosmolarity is a universally recognized characteristic of DED [5,31]. Increased tear osmolarity activates the mitogen-activated protein kinase (MAPK) signal transduction pathway, which leads to the activation of transcription factors such as activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB), causing IL-1β overexpression [32,33].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dry Eye Disease on Scar Formation in Rabbit Glaucoma Filtration Surgery

Hong¹,

Zhu²,

Zhang³

et al. 2017

IJMS

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The success rate of glaucoma filtration surgery is closely related to conjunctival inflammation, and the main mechanism of dry eye disease (DED) is inflammation. The aim of this study was to evaluate the effect of DED on bleb scar formation after rabbit glaucoma filtration surgery. Sixteen New Zealand white rabbits were randomly divided into control and DED groups. A DED model was induced by twice-daily topical administration of 0.1% benzalkonium chloride (BAC) drops for three weeks. Ocular examinations were performed to verify the DED model. Surgical effects were assessed, and histologic assessments were performed on the 28th postoperative day. Higher fluorescein staining scores, lower basal tear secretion levels and goblet cell counts, and increased interleukin 1β (IL-1β) levels were observed in the DED group. The DED eyes displayed significantly higher intraocular pressure (IOP)% on the 14th postoperative day; a smaller bleb area on days 14, 21 and 28; and a shorter bleb survival time. Moreover, proliferating cell nuclear antigen (PCNA) and alpha-smooth muscle actin (α-SMA) levels were significantly increased in the DED group. These results demonstrate that DED promotes filtering bleb scar formation and shortens bleb survival time; these effects may be mediated via IL-1β.

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“…[10] provide a systematic review focused on present challenges in the management of and future innovative trends to positively impact dry eye disease (DED). This tear film disorder results in hyperosmolarity of the tear film and inflammation of the ocular surface.…”

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confidence: 99%

“…In their review article, Al-Saedi et al . [10] provide an overview of DED, its classification, epidemiology, pathophysiology, diagnosis, and risk factors. Special emphasis is placed on current treatment options for DED, such as artificial tears, lipid-containing lubricants, liposomal spray, inserts, anti-inflammatory or immunosuppressant drops, antibiotics, dietary omega-3 essential fatty acids, autologous serum, intense-pulsed-light (IPL), punctual plugs, moisture-retaining eyeglasses, hydrophilic bandage contact lenses and secretagogues.…”

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confidence: 99%

Editorial (Thematic Issue: Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Dev elopment (Part C))

Kamal

Greig²

2016

CPD

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In the fields of pharmacological, biotechnological and medical sciences, numerous billions of dollars are spent annually on basic and clinical research and development to better understand and promote global health. These funds support scientific, clinical and administrative salaries, chemicals, instruments and consumables, preclinical research and clinical trials, laboratory infrastructure and numerous other essential costs in relation multiple research projects undertaken across different laboratories around the globe, as science – like disease - knows no borders. Small and large scientific advances are continuously being made across areas, but how does one optimally combine and focus them to maximize their united impact on disease management. The goal of this special issue of Current Pharmaceutical Design (CPD) is to aid medical research in this endeavor by providing articles to overview current progress and future perspectives focused towards management strategies for diverse diseases. Particular challenges facing numerous laboratories are those that involve laboratory bench to clinical bedside translation in the path of successful drug discovery. Are there ways to tailor and optimize this across disorders; are there guidelines that best should be followed? Authors of this special issue were invited to generate a review article appropriate to describe technologies with potential value across diseases to provide a guiding light to identify courses of action and procedures for clinically translatable research that can both advance the success rate and shorten the timeline to support a treatment to positively impact public health goals, globally.

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Dry Eye Disease: Present Challenges in the Management and Future Trends

Cited by 47 publications

References 0 publications

Effects of intranasal administration of violet oil in dry eye disease

Effects of intranasal administration of violet oil in dry eye disease

The Effect of Dry Eye Disease on Scar Formation in Rabbit Glaucoma Filtration Surgery

Editorial (Thematic Issue: Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Dev elopment (Part C))

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