Dry Powders for Pulmonary Delivery of Peptides and                    Proteins

Okamoto, Hirokazu; Todo, Hiroaki; Iida, Kotaro; Danjo, Kazumi

doi:10.14356/kona.2002010

Cited by 33 publications

(11 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is now accepted that aerosol inhalation therapy is not simply the preferred route for the treatment of respiratory disorders 1) , but it may also offer significant advantages in targeting the systemic circulation [1][2][3][4] . The large surface area 5) , sluggish clearance 6) , and low proteolytic activity 7) of the alveolar region provide for the opportunity of fast drug uptake, second only to the intravenous route 8) , and (typically) enhanced drug bioavailability 5,9) .…”

Section: Introductionmentioning

confidence: 99%

Applications of the Atomic Force Microscope in the Development of Propellant-based Inhalation Formulations

Rocha

2008

KONA

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Applications of the Atomic Force Microscope in the Development of Propellant-based Inhalation Formulations

Rocha

2008

KONA

View full text Add to dashboard Cite

show abstract

“…It is also known that chemical stability of peptides and proteins in the dry state is enhanced by the presence of certain amorphous sugars (Okamoto et al, 2002). Sugars can protect peptides and proteins against loss of activity through chemical and thermal denaturation.…”

Section: Discussionmentioning

confidence: 99%

Delivery of salmon calcitonin using a microneedle patch

Taş

Mansoor

Kalluri

et al. 2012

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Peptides and polypeptides have important pharmacological properties but only a limited number have been exploited as therapeutics because of problems related to their delivery. Most of these drugs require a parenteral delivery system which introduces the problems of pain, possible infection, and expertise required to carry out an injection. The aim of this study was to develop a transdermal patch containing microneedles (MNs) coated with a peptide drug, salmon calcitonin (sCT), as an alternative to traditional subcutaneous and nasal delivery routes. Quantitative analysis of sCT after coating and drying onto microneedles was performed with a validated HPLC method. In vivo studies were carried out on hairless rats and serum levels of sCT were determined by ELISA. The AUC value of MNs coated with a trehalose-containing formulation (250 ± 83 ng/mL.min) was not significantly different as compared to subcutaneous injections (403 ± 253 ng/mL.min), but approximately 13 times higher than nasal administration (18.4 ± 14.5 ng/mL.min). Tmax (7.5 ± 5 min) values for MN mediated administration were 50% shorter than subcutaneous injections (15 min), possibly due to rapid sCT dissolution and absorption by dermal capillaries. These results suggest that with further optimization of coating formulations, microneedles may enable administration of sCT and other peptides without the need for hypodermic injections.

show abstract

“…Particles with aerodynamic particle size between 0.5 and 5.8 μm are considered in the respirable range and well suited for deposition into the distal lungs (12). The aerodynamic size Fig.…”

Section: Discussionmentioning

confidence: 99%

Insulin Lung Deposition and Clearance Following Technosphere® Insulin Inhalation Powder Administration

et al. 2011

View full text Add to dashboard Cite

TI inhalation powder administered via the MedTone inhaler was uniformly distributed throughout the lungs; ~40% of the initial cartridge load reached the lungs. Insulin and FDKP are quickly cleared from the lungs, mainly by absorption into the systemic circulation. The terminal clearance half-life from the lung ELF, estimated from sequential BAL fluid measurements for both components, was ~1 hour. Since there is an overnight washout period, the potential for accumulation on chronic administration is minimal.

show abstract

Dry Powders for Pulmonary Delivery of Peptides and Proteins

Abstract: Abstract

Cited by 33 publications

References 78 publications

Applications of the Atomic Force Microscope in the Development of Propellant-based Inhalation Formulations

Applications of the Atomic Force Microscope in the Development of Propellant-based Inhalation Formulations

Delivery of salmon calcitonin using a microneedle patch

Insulin Lung Deposition and Clearance Following Technosphere® Insulin Inhalation Powder Administration

Contact Info

Product

Resources

About