Dry skin (xerosis) in patients undergoing maintenance haemodialysis: the role of decreased sweating of the eccrine sweat gland

Park, T.-H.; Park, C.-H.; Ha, Sungji; Lee, S.-H.; Song, Kyungchul; Lee, H.-Y.; Han, Dae Suk

doi:10.1093/ndt/10.12.2269

Cited by 29 publications

(20 citation statements)

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“…However, we did not confirm any significant relationship between the severity of pruritus and conductance values both at pre-and postdialysis. These data supported a minor role of xerosis to the development of pruritus in HD patients, as reported previously [4][5][6][7][8].…”

Section: Discussionsupporting

confidence: 92%

Pruritus and Hydration State of Stratum corneum in Hemodialysis Patients

et al. 2000

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Background: Xerosis is the most frequent cutaneous manifestation in hemodialysis (HD) patients, but the association between dry skin and pruritus remains to be clarified. Since the skin surface hygrometer can detect the changes of water content in the stratum corneum more sensitively, we re-examined the relationship between the severity of pruritus and water content in dialysis patients. Methods: Fifty patients who had been undergoing regular HD were examined for the degree of pruritus by clinical grading. Water contents in the stratum corneum at volar forearm and lower leg were assessed by measurement of high-frequency conductance using a skin surface hygrometer both at pre- and postdialysis. Results: Thirty-seven (74%) of dialysis patients complained of pruritus. High-frequency conductance values were significantly lower in HD patients compared to those of age-matched control subjects (n = 13) both at forearm (35.1 ± 3.0 vs. 73.3 ± 10.4 µS, p < 0.01) and lower leg (14.2 ± 1.1 vs. 52.4 ± 7.5 µS, p < 0.01). There was no relationship between the severity of pruritus and age, gender, HD duration, underlying renal disease, or removing fluid volume. A significant reduction of itching score was found in patients using polysulfone membrane. A single HD session using cellulose triacetate or polysulfone membrane significantly increased water content both at forearm and lower leg (p < 0.05). However, the degree of pruritus did not correlate with the skin water content both at the beginning and the end of HD session, respectively. Conclusion: It follows from these findings that water content in the stratum corneum was reduced in HD patients, but did not correlate with the severity of pruritus.

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Section: Discussionsupporting

confidence: 92%

Pruritus and Hydration State of Stratum corneum in Hemodialysis Patients

et al. 2000

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“…Features of atopy, associated with dry skin and keratosis pilaris-like lesions were seen in eight patients. A reduction in the size and functional abnormality of eccrine sweat glands, suggesting compromised eccrine secretion leading to epithelial dehydration[12] may contribute to the development of xerosis.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of cutaneous abnormalities in patients with chronic kidney disease

2012

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There are diverse ways in which the skin is affected by chronic kidney disease (CKD). Various specific and nonspecific skin abnormalities are observed in patients with CKD. The aim of the study was to document the prevalence of skin diseases that commonly occur in patients with CKD on medical treatment and dialysis. A total of 99 patients with CKD were examined for evidence of skin diseases. Ninety-six had at least one cutaneous abnormality attributable to CKD. The most prevalent finding was xerosis (66.7%), followed by pallor (45.45%), pruritus (43.4%), and cutaneous pigmentation (32.3%). Other cutaneous manifestations included dermatitis (27.27%); Kyrle's disease (17.17%); fungal (8.08%), bacterial (11.1%), and viral (5.05%) infections; purpura (10.1%); gynecomastia (4.04%); and yellow skin (5.05%). The common nail changes were half and half nails (36.36%) and onycholysis (13.13%). CKD is associated with various cutaneous abnormalities caused either by the disease or by treatment, the most common being xerosis and pruritus. The dermatologic complications can significantly impair the quality of life in certain individuals; therefore, earlier diagnosis and treatment is important to improve their quality of life.

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“…[40][41] Most studies did not find any direct relationship between xerosis and uraemic pruritus. 24, 21,42 Add that, emollients have only a partial improvement in pruritus.…”

Section: J Dermatolmentioning

confidence: 99%